YRC Public Data Repository - Protein Structure Prediction

Protein:	FOL1
Organism:	Saccharomyces cerevisiae
Length:	824 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for FOL1.

Description	E-value	Query Range	Subject Range
FOL1 - Multifunctional enzyme of the folic acid biosynthesis pathway, has dihydropteroate synthetase, dihyd... FOL1_YEAST - Folic acid synthesis protein FOL1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=FOL1 P... gi\|190409229 - gi\|190409229\|gb\|EDV12494.1\| dihydro-6-hydroxymethylpterin pyrophosphokinase [Saccharomyces cerevisia...	0.0	[1..824]	[1..824]
gi\|45199166, gi\|... - gi\|45199166\|ref\|NP_986195.1\| AFR647Cp [Ashbya gossypii ATCC 10895], gi\|44985306\|gb\|AAS54019.1\| AFR64... gi\|44985306 - gi\|44985306\|gb\|AAS54019.1\| AFR647Cp [Ashbya gossypii ATCC 10895]	0.0	[14..821]	[27..818]
FOL1_PNECA - Folic acid synthesis protein fol1 OS=Pneumocystis carinii GN=fol1 PE=1 SV=1	0.0	[11..821]	[28..737]
gi\|23953859 - gi\|23953859\|gb\|AAN38834.1\| folic acid synthesis protein [Pneumocystis carinii f. sp. macaca]	0.0	[12..823]	[31..740]
orf19.579 - FOL1 CGDID:CAL0000317 Assembly 19, Contig19-10057 (26150, 23784) CDS, reverse complemented, translat... gi\|46435754, gi\|... - gi\|68483697\|ref\|XP_714207.1\| likely multifunctional folic acid biosynthesis enzyme [Candida albicans...	0.0	[21..823]	[4..788]
SPBC1734.03 - dihydropteroatesynthase /2-amino-4-hydroxy-6-hydroxymethyldihydropteridinediphosphokinase /dihydroneop... FOL1_SCHPO - Folic acid synthesis protein fol1 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=fol1 PE=...	0.0	[21..820]	[5..683]
gi\|49077970, gi\|... - gi\|71022175\|ref\|XP_761318.1\| hypothetical protein UM05171.1 [Ustilago maydis 521], ref\|XP_402786.1\| ...	0.0	[9..821]	[2..861]
gi\|50939293, gi\|... - gi\|50939293\|ref\|XP_479174.1\| putative dihydropterin pyrophosphokinase /dihydropteroate synthase [Ory...	0.0	[274..822]	[44..530]
FOLM_ARATH - Folate synthesis bifunctional protein, mitochondrial OS=Arabidopsis thaliana GN=MitHPPK/DHPS PE=2 SV...	0.0	[239..821]	[21..548]

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Predicted Domain #1

Region A:
Residues: [1-140]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSKLFSTVNS ARHSVPLGGM RDYVHIKKLE MNTVLGPDSW NQLMPQKCLL SLDMGTDFSK  60
   61 SAATDDLKYS LNYAVISRDL TNFVSKKKNW GSVSNLAKSV SQFVMDKYSG VECLNLEVQA 120
  121 DTTHIRSDHI SCIIQQERGN

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	33.39794
Match:	1sqlA
Description:	Crystal structure of 7,8-dihydroneopterin aldolase in complex with guanine
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
GTP cyclohydrolase I activity	4.1430878480831	bayes_pls_golite062009
cyclohydrolase activity	3.66553359909123	bayes_pls_golite062009
GTP cyclohydrolase activity	3.44912994722205	bayes_pls_golite062009
6-pyruvoyltetrahydropterin synthase activity	2.77658228107642	bayes_pls_golite062009
dihydroneopterin aldolase activity	2.51107306055654	bayes_pls_golite062009
catalytic activity	2.20788162511962	bayes_pls_golite062009
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines	1.73101699306211	bayes_pls_golite062009
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	0.974891318710762	bayes_pls_golite062009
binding	0.641976427105342	bayes_pls_golite062009
oxidoreductase activity	0.0783540825826956	bayes_pls_golite062009
protein binding	0.045916344848404	bayes_pls_golite062009
urate oxidase activity	0.0294957696532921	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [141-295]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PESQEFDVVR ISELKMLTLI GVFTFERLKK QYVTLDIKLP WPKKAELPPP VQSIIDNVVK  60
   61 FVEESNFKTV EALVESVSAV IAHNEYFQKF PDSPLVVKVL KLNAITATEG VGVSCIREPR 120
  121 EIAMVNIPYL SSIHESSDIK FQLSSSQNTP IEGKN

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	62.69897
Match:	2cg8A
Description:	No description for 2cg8A was found.

Predicted Domain #3

Region A:
Residues: [296-824]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TWKRAFLAFG SNIGDRFKHI QMALQLLSRE KTVKLRNISS IFESEPMYFK DQTPFMNGCV  60
   61 EVETLLTPSE LLKLCKKIEY EELQRVKHFD NGPRTIDLDI VMFLNSAGED IIVNEPDLNI 120
  121 PHPRMLERTF VLEPLCELIS PVHLHPVTAE PIVDHLKQLY DKQHDEDTLW KLVPLPYRSG 180
  181 VEPRFLKFKT ATKLDEFTGE TNRITVSPTY IMAIFNATPD SFSDGGEHFA DIESQLNDII 240
  241 KLCKDALYLH ESVIIDVGGC STRPNSIQAS EEEEIRRSIP LIKAIRESTE LPQDKVILSI 300
  301 DTYRSNVAKE AIKVGVDIIN DISGGLFDSN MFAVIAENPE ICYILSHTRG DISTMNRLAH 360
  361 YENFALGDSI QQEFVHNTDI QQLDDLKDKT VLIRNVGQEI GERYIKAIDN GVKRWQILID 420
  421 PGLGFAKTWK QNLQIIRHIP ILKNYSFTMN SNNSQVYVNL RNMPVLLGPS RKKFIGHITK 480
  481 DVDAKQRDFA TGAVVASCIG FGSDMVRVHD VKNCSKSIKL ADAIYKGLE

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	171.0
Match:	2bmbA
Description:	X-ray structure of the bifunctional 6-hydroxymethyl-7,8- dihydroxypterin pyrophosphokinase dihydropteroate synthase from Sacchromyces cerevisiae
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: