Protein Overview: PEX7

General Information:
Name(s) found:	PEX7 / YDR142C [SGD]
Description(s) found: Found 33 descriptions. SHOW ALL	Peroxisomal signal receptor for the N-terminal nonapeptide signal (PTS2) of peroxisomal matrix proteins; WD repeat protein; defects in human homolog cause lethal rhizomelic chondrodysplasia punctata (RCDP) [SGD]
Organism:	Saccharomyces cerevisiae
Length:	375 amino acids
Gene Ontology:
Cellular Component:	cytosol [IDA] peroxisomal matrix [IDA][TAS]
Biological Process:	protein targeting to peroxisome [IMP][TAS] peroxisome organization [TAS]
Molecular Function:	peroxisome matrix targeting signal-2 binding [IPI] peroxisome targeting sequence binding [IGI]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLRYHMQGFS GYGVQYSPFF DNRLAVAAGS NFGLVGNGKL FILEIDRSGR IVEVNSFLTQ  60
   61 DCLFDLAWNE SHENQVLVAQ GDGTLRLFDT TFKEFPIAIF KEHEREVFSC NWNLVNRQNF 120
  121 LSSSWDGSIK IWSPLRKQSL MTLTPRPLEI TKMVDPLNAI ILKKKSFTGI SKNRNCVYQA 180
  181 QFSPHDQNLV LSCSGNSYAS LFDIRLPSGK NQNNFLVHSG LEALTCDFNK YRPYVVATGG 240
  241 VDNAIRIWDI RMLNKNESAT IKRTVPGQLH NSSCINEIPN AHGLAIRKVT WSPHHSNILM 300
  301 SASYDMTCRI WRDLSNDGAK ETYKTNSTDA TKGSIFNFTQ HSEFVFGADW SLWGKPGYVA 360
  361 STAWDGNLFV WNGLG

Protein Complex Data

	PUBLICATION	TOPOLOGY	COCOMPLEXED PROTEINS
View Details	Hazbun TR, et al. (2003)		HOL1 MMP1 PEX7 PLB1 YJR012C
View Details	Krogan NJ, et al. (2006)		PEX7 YJR012C
View Details	Ho Y, et al. (2002)		CCT2 CCT3 CCT5 CCT6 FZO1 LAP4 MYO2 NEW1 PEX7 RPN6 SEC6 SEN2 UBR1
View Details	Qiu et al. (2008)		INP2 PEX13 PEX7 PEX8

Mass Spectrometry Data

The following runs contain data for this protein:

	BAIT	COMMENTS	PUBLICATION
View Run	YJR012C	No Comments	Hazbun TR, et al. (2003)
View Run	MLP2	#10 Mitotic Prep1-TiO2 Phosphopeptide enrichment	Keck JM, et al. (2011)
View Run	None Entered	#17 Mitotic Prep3-TiO2 Phosphopeptide enrichment	Keck JM, et al. (2011)

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

	BAIT	PREY	HITS	PUBLICATION
View Screen	UBC7	PEX7	1	Unpublished Fields Lab Data

Microscopy / Localization Data

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No microscopy data found in the PDR for this protein.

Protein Structure Data

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[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..375]	PSI-BLAST	58.0	beta1-subunit of the signal-transducing G protein heterotrimer

Functions predicted (by domain):

Gene Ontology predictions

Term	Confidence	Notes
peroxisome targeting sequence binding	2.43196533618619	bayes_pls_golite062009
binding	2.2778252170547	bayes_pls_golite062009
peroxisome matrix targeting signal-2 binding	1.26984584070766	bayes_pls_golite062009
protein binding	1.24173112731149	bayes_pls_golite062009
nucleic acid binding	0.520265606469501	bayes_pls_golite062009
general RNA polymerase II transcription factor activity	0.518364053507325	bayes_pls_golite062009
	0.45054027253231	bayes_pls_golite062009
cytoskeletal protein binding	0.359536347486199	bayes_pls_golite062009
snoRNA binding	0.283655461357951	bayes_pls_golite062009
transcription regulator activity	0.261490211382488	bayes_pls_golite062009

Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

Philius Transmembrane Prediction:

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.90

Source: Reynolds et al. (2008)

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2