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Protein Overview: TSC13

General Information:
Name(s) found: TSC13 / YDL015C [SGD]
Description(s) found:
Found 28 descriptions.
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  • Enoyl reductase that catalyzes the last step in each cycle of very long chain fatty acid elongation, localizes to the ER, highly enriched in a structure marking nuclear-vacuolar junctions, coimmunoprecipitates with elongases Fen1p and Sur4p [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 310 amino acids

    Gene Ontology:
    Cellular Component: endoplasmic reticulum membrane [IDALink to PubMed article][IGILink to PubMed article][ISSLink to PubMed article]
    mitochondrion [IDALink to PubMed articleLink to PubMed article]
    Biological Process: very long-chain fatty acid metabolic process [IGILink to PubMed article][IMPLink to PubMed article][IPILink to PubMed article]
    Molecular Function: oxidoreductase activity [IMPLink to PubMed article][ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPITIKSRSK GLRDTEIDLS KKPTLDDVLK KISANNHNIS KYRIRLTYKK ESKQVPVISE  60
   61 SFFQEEADDS MEFFIKDLGP QISWRLVFFC EYLGPVLVHS LFYYLSTIPT VVDRWHSASS 120
  121 DYNPFLNRVA YFLILGHYGK RLFETLFVHQ FSLATMPIFN LFKNCFHYWV LSGLISFGYF 180
  181 GYGFPFGNAK LFKYYSYLKL DDLSTLIGLF VLSELWNFYC HIKLRLWGDY QKKHGNAKIR 240
  241 VPLNQGIFNL FVAPNYTFEV WSWIWFTFVF KFNLFAVLFL TVSTAQMYAW AQKKNKKYHT 300
  301 RRAFLIPFVF

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) CTP1 ERV25 FKS1 FTR1 MRH1 OLE1 PEX27 ROG3 RPL10 RPL36B RPL37A RPP1A SEC11 SPC1 SPC2 SPC3 TCM62 TSC13 YNR021W

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen UBP6 TSC13 2 Unpublished Fields Lab Data

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data TSC13 Huh WK, et al. (2003)

    Protein Structure Data


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    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..116] MSA 1.028978 View MSA. No confident structure predictions are available.
    2 View Details [117..310] Pfam 73.148742 3-oxo-5-alpha-steroid 4-dehydrogenase No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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