Protein Overview: ARE1

General Information:
Name(s) found:	ARE1 / YCR048W [SGD]
Description(s) found: Found 24 descriptions. SHOW ALL	Acyl-CoA:sterol acyltransferase, isozyme of Are2p; endoplasmic reticulum enzyme that contributes the major sterol esterification activity in the absence of oxygen [SGD]
Organism:	Saccharomyces cerevisiae
Length:	610 amino acids
Gene Ontology:
Cellular Component:	endoplasmic reticulum [IDA]
Biological Process:	sterol metabolic process [IMP]
Molecular Function:	sterol O-acyltransferase activity [IDA]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTETKDLLQD EEFLKIRRLN SAEANKRHSV TYDNVILPQE SMEVSPRSST TSLVEPVEST  60
   61 EGVESTEAER VAGKQEQEEE YPVDAHMQKY LSHLKSKSRS RFHRKDASKY VSFFGDVSFD 120
  121 PRPTLLDSAI NVPFQTTFKG PVLEKQLKNL QLTKTKTKAT VKTTVKTTEK TDKADAPPGE 180
  181 KLESNFSGIY VFAWMFLGWI AIRCCTDYYA SYGSAWNKLE IVQYMTTDLF TIAMLDLAMF 240
  241 LCTFFVVFVH WLVKKRIINW KWTGFVAVSI FELAFIPVTF PIYVYYFDFN WVTRIFLFLH 300
  301 SVVFVMKSHS FAFYNGYLWD IKQELEYSSK QLQKYKESLS PETREILQKS CDFCLFELNY 360
  361 QTKDNDFPNN ISCSNFFMFC LFPVLVYQIN YPRTSRIRWR YVLEKVCAII GTIFLMMVTA 420
  421 QFFMHPVAMR CIQFHNTPTF GGWIPATQEW FHLLFDMIPG FTVLYMLTFY MIWDALLNCV 480
  481 AELTRFADRY FYGDWWNCVS FEEFSRIWNV PVHKFLLRHV YHSSMGALHL SKSQATLFTF 540
  541 FLSAVFHEMA MFAIFRRVRG YLFMFQLSQF VWTALSNTKF LRARPQLSNV VFSFGVCSGP 600
  601 SIIMTLYLTL

Protein Complex Data

	PUBLICATION	TOPOLOGY	COCOMPLEXED PROTEINS
View Details	Ho Y, et al. (2002)		AIM46 ARE1 CDC33 FET4 FUN12 GRS1 HAS1 IMD2 IMD3 IMD4 KRE33 KRI1 MAG2 MGM101 MSC3 NOC2 NOP12 NOP4 NPL3 OYE2 PDC6 RPF2 RRP12 TIF4631 TIF4632 UTP22
View Details	Qiu et al. (2008)		ARE1 ARE2 ATF2

Mass Spectrometry Data

The following runs contain data for this protein:

	BAIT	COMMENTS	PUBLICATION
View Run	MLP2	#03 Alpha Factor Prep1-TiO2 Flowthrough	Keck JM, et al. (2011)
View Run	MLP2	#12 Mitotic Prep1-TiO2 Flowthrough	Keck JM, et al. (2011)
View Run	MLP2	#11 Mitotic Prep1-TiO2 enriched, new search criteria	Keck JM, et al. (2011)

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

	BAIT	PREY	HITS	PUBLICATION
View Screen	GPI14	ARE1	2	Hazbun TR, et al. (2003)
View Screen	ILM1	ARE1	2	Lockshon D, et al. (2006)

Microscopy / Localization Data

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	PROTEIN(S)	PUBLICATION
View Data	ARE1	Huh WK, et al. (2003)

Protein Structure Data

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[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..131]	deduced	N/A	No confident structure predictions are available.
2	View Details	[132..315]	MSA	1.026978	View MSA. No confident structure predictions are available.
3	View Details	[316..367]	deduced	N/A	No confident structure predictions are available.
4	View Details	[368..610]	Pfam	129.200659	No description for PF01800 was found. No confident structure predictions are available.
5	View Details	[499..610]	MSA	2.096997	View MSA. No confident structure predictions are available.

Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

Philius Transmembrane Prediction:

[View Details]

Source: Reynolds et al. 2008. Manuscript submitted

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2