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Protein Overview: FEN2

General Information:
Name(s) found: FEN2 / YCR028C [SGD]
Description(s) found:
Found 28 descriptions.
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  • Plasma membrane H+-pantothenate symporter; confers sensitivity to the antifungal agent fenpropimorph [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 512 amino acids

    Gene Ontology:
    Cellular Component: plasma membrane [IGILink to PubMed article][ISSLink to PubMed article]
    Biological Process: endocytosis [IMPLink to PubMed article]
    pantothenate transmembrane transport [IGILink to PubMed article][IMPLink to PubMed article]
    Molecular Function: pantothenate transporter activity [IGILink to PubMed article][IMPLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MMKESKSITQ HEVERESVSS KRAIKKRLLL FKIDLFVLSF VCLQYWINYV DRVGFTNAYI  60
   61 SGMKEDLKMV GNDLTVSNTV FMIGYIVGMV PNNLMLLCVP PRIWLSFCTF AWGLLTLGMY 120
  121 KVTSFKHICA IRFFQALFES CTFSGTHFVL GSWYKEDELP IRSAIFTGSG LVGSMFSGFM 180
  181 QTSIFTHLNG RNGLAGWRWL FIIDFCITLP IAIYGFIFFP GLPDQTSAVS KFSMTRYIFN 240
  241 EQELHYARRR LPARDESTRL DWSTIPRVLK RWHWWMFSLV WVLGGENLGF ASNSTFALWL 300
  301 QNQKYTLAQR NNYPSGIFAV GIVSTLCSAV YMSKIPRARH WHVSVFISLV MVIVAVLIRA 360
  361 DPLNPKVVFS AQYLGGVAYA GQAVFFSWAN IICHADLQER AIVLASMNMF SGAVNAWWSI 420
  421 LFFASDMVPK FERGCYALLA TAISSGIVSV VIRSLQIKEN LSKKQVPYID ANDMPGEDDD 480
  481 DDNQDNENDG DDESMEVELH NEEMAEISNP FR

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Qiu et al. (2008) FEN2 THI7

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run TOR1 No Comments Reinke A, et al. (2004)
    View Run ZDS1 Sample 3 - cpn + atp, from june 2005 McCusker D, et al (2007)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen RAD6 FEN2 1 Unpublished Fields Lab Data
    View Screen YJR141W FEN2 1 Unpublished Fields Lab Data
    View Screen LOS1 FEN2 1 Unpublished Fields Lab Data
    View Screen UBC7 FEN2 1 Unpublished Fields Lab Data
    View Screen RAD1 FEN2 1 Unpublished Fields Lab Data

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data FEN2 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..220]
    [261..512]    		 PSI-BLAST 38.69897 No description for 1ja5A_ was found.
    2 View Details [221..260] PSI-BLAST 38.69897 No description for 1ja5A_ was found.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • substrate-specific transmembrane transporter activity
    		•  5.21742729128468 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  4.31748220369305 bayes_pls_golite062009
  • transporter activity
    		•  4.09176719149278 bayes_pls_golite062009
  • anion transmembrane transporter activity
    		•  3.74166040263114 bayes_pls_golite062009
  • cation transmembrane transporter activity
    		•  3.60627834007397 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  3.5865018981083 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  3.3426261924492 bayes_pls_golite062009
  • inorganic anion transmembrane transporter activity
    		•  2.17838823008408 bayes_pls_golite062009
  • active transmembrane transporter activity
    		•  1.59419818573076 bayes_pls_golite062009
  • binding
    		•  1.3181781780038 bayes_pls_golite062009
  • secondary active transmembrane transporter activity
    		•  1.22264637452409 bayes_pls_golite062009
  • polyol transmembrane transporter activity
    		•  0.924836669821548 bayes_pls_golite062009
  • alcohol transmembrane transporter activity
    		•  0.924836669821548 bayes_pls_golite062009
  • glycerol transmembrane transporter activity
    		•  0.812001619402678 bayes_pls_golite062009
  • solute:cation symporter activity
    		•  0.74591237387473 bayes_pls_golite062009
  • symporter activity
    		•  0.74591237387473 bayes_pls_golite062009
  • phosphate transmembrane transporter activity
    		•  0.312628600969375 bayes_pls_golite062009
  • cation:sugar symporter activity
    		•  0.143419068761182 bayes_pls_golite062009
  • sugar:hydrogen symporter activity
    		•  0.143419068761182 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle