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Protein Overview: CWH43

General Information:
Name(s) found: CWH43 / YCR017C [SGD]
Description(s) found:
Found 23 descriptions.
SHOW ALL
  • Putative sensor/transporter protein involved in cell wall biogenesis; contains 14-16 transmembrane segments and several putative glycosylation and phosphorylation sites; null mutation is synthetically lethal with pkc1 deletion [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 953 amino acids

    Gene Ontology:
    Cellular Component: integral to plasma membrane [IDALink to PubMed article]
    cellular bud tip [IDALink to PubMed article]
    cellular bud neck [IDALink to PubMed article]
    Biological Process: signal transduction [IGILink to PubMed article]
    cellular cell wall organization [IGILink to PubMed article]
    Molecular Function: molecular_function [ND]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLIINGKIIP IAHTICAFSA FFAALVTGYS LHFHKIVTNA HYTYPDEWFP SVSATIGDRY  60
   61 PERSIFQILI ALTAFPRFLL LLGHYYLNQS KVCFLVGVLR TVSCGGWVYI TSTDDHDIHD 120
  121 IFMITYIVLT LPWDIMITRY SSPLTSKNKG LTATIFFGTL FPMIYWYIQH SVQQRAGAYS 180
  181 IYAYFEWSLI LLDIAFDAFA YADFKKIDIV LAFNEKPGNT SFFQIRDSSP INYGEEKSSE 240
  241 LQKSGEKKVE KEKPVARSAT GSYFRFDSFF YLLTNIFNGF LFWSNVTSLL CSIWHFPLWY 300
  301 MGISGYEAAI LGYLGPIFLY LPFVSEAFTQ YGVLLGGIIA IGAYIVQMPE LRLISVAVGT 360
  361 SITVATFVQN LRYITNAETS FSFALTWLLG LVASVILKMG FYTNNPTWVI LDERNGGYNK 420
  421 TALVLTVLFG MLSPYVNSIN FEGKRNAQAK SASLIGKLFL AVGFGSLLFG IHQLLTDSST 480
  481 TIYWAWEGYN ESHGPLPWPW GALTCTVMLF ASLSSVKFMG KPLVPCLLLL ISTAVLSARS 540
  541 ITQWPKYIFG GLLYAIAMLW LVPSYFSALG QVQNIWVYVL SFSVYIIFVL AHVWVVAYAF 600
  601 VPMGWVLREK IETVLAFSST FIIIGALTCK NLNIQLVTMG KKFFIYVFFF AVALLSLTAR 660
  661 FVYDIRPTGI PQPYHPDSQL ITAGIWTIHF GLDNDMWASE DRMINLIKDM ELDVVGLLET 720
  721 DTQRITMGNR DLTSKLAHDL NMYADFGPGP NKHTWGCVLL SKFPIVNSTH HLLPSPVGEL 780
  781 APAIHATLQT YNDTLVDVFV FHSGQEEDEE DRRLQSNYMA KLMGNTTRPA ILLSYLVVDP 840
  841 GEGNYNTYVS ETSGMHDIDP SDDDRWCEYI LYRGLRRTGY ARVARGTITD TELQVGKFQV 900
  901 LSEQALVEHS DSMYEYGHMS EPEYEDMKFP DKFLGEGERG HFYHVFDEPR YYL

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run CEP3 sample cbf3 from feb 2005 Sandall S, et all (2006)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data CWH43 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..242] MSA 6.009954 View MSA. No confident structure predictions are available.
    2 View Details [243..631] deduced N/A No confident structure predictions are available.
    3 View Details [632..953] PSI-BLAST 40.39794 DNA repair endonuclease Hap1
    4 View Details [501..614] deduced N/A No confident structure predictions are available.
    5 View Details [615..953] PSI-BLAST 44.154902 No description for 2isiA was found.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3 No functions predicted.
    4 No functions predicted.
    5
    Term Confidence Notes
  • inositol or phosphatidylinositol phosphatase activity
    		•  5.08340215818195 bayes_pls_golite062009
  • phosphatidylinositol bisphosphate phosphatase activity
    		•  4.31986043742678 bayes_pls_golite062009
  • phosphoinositide 5-phosphatase activity
    		•  4.20326783658706 bayes_pls_golite062009
  • phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity
    		•  4.20326783658706 bayes_pls_golite062009
  • inositol-polyphosphate 5-phosphatase activity
    		•  2.94523020814127 bayes_pls_golite062009
  • inositol trisphosphate phosphatase activity
    		•  2.92493218089814 bayes_pls_golite062009
  • hydrolase activity, acting on ester bonds
    		•  2.04540265799637 bayes_pls_golite062009
  • lipid phosphatase activity
    		•  1.80791721648826 bayes_pls_golite062009
  • catalytic activity
    		•  1.76511376991978 bayes_pls_golite062009
  • phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity
    		•  1.54959696750258 bayes_pls_golite062009
  • phosphatidylinositol-4-phosphate phosphatase activity
    		•  1.54959696750258 bayes_pls_golite062009
  • phosphatase activity
    		•  1.49726164551553 bayes_pls_golite062009
  • phosphoric ester hydrolase activity
    		•  1.44905138167792 bayes_pls_golite062009
  • binding
    		•  1.31660174492743 bayes_pls_golite062009
  • phosphatidylinositol trisphosphate phosphatase activity
    		•  0.731013770154616 bayes_pls_golite062009
  • phosphatidylinositol-3-phosphatase activity
    		•  0.725138642234872 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.652905853950749 bayes_pls_golite062009
  • nuclease activity
    		•  0.623968581242132 bayes_pls_golite062009
  • deoxyribonuclease activity
    		•  0.620825895803427 bayes_pls_golite062009
  • DNA binding
    		•  0.524359544607599 bayes_pls_golite062009
  • protein binding
    		•  0.476649214025345 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.312330562637603 bayes_pls_golite062009
  • hydrolase activity
    		•  0.283637370318741 bayes_pls_golite062009
  • exonuclease activity
    		•  0.219613338022829 bayes_pls_golite062009
  • exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters
    		•  0.213742479001316 bayes_pls_golite062009


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle