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Protein Overview: KCC4

General Information:
Name(s) found: KCC4 / YCL024W [SGD]
Description(s) found:
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  • gi|32363493|sp|P25389.3|KCC4_YEAST RecName: Full=Probable serine/threonine-protein kinase KCC4 [NCBI NR]
  • gi|14588913|emb|CAC42961.1| kinase [Saccharomyces cerevisiae] [NCBI NR]
  • gi|10383767|ref|NP_009907.2| Protein kinase of the bud neck involved in the septin checkpoint, associates with septin proteins, negatively regulates Swe1p by phosphorylation, shows structural homology to bud neck kinases Gin4p and Hsl1p; Kcc4p [Saccharomy [NCBI NR]
  • Probable serine/threonine-protein kinase KCC4 OS=Saccharomyces cerevisiae GN=KCC4 PE=1 SV=3 [Swiss-Prot]
  • KCC4 Kinase coordinate cell cycle progression with the organization of the peripheralcytoskeleton [mips]
  • Protein kinase of the bud neck involved in the septin checkpoint, associates with septin proteins, negatively regulates Swe1p by phosphorylation, shows structural homology to bud neck kinases Gin4p and Hsl1p [SGD]
  • KCC4, Chr III from 79161-82274 [yeast_orfs2]
  • Chr III from 79161-82274 [yeastorf3.fasta]
  • (P25389) Probable serine/threonine-protein kinase KCC4 (EC 2.7.1.37) [4932.FASTACCERV.txt]
  • KCC4 SGDID:S0000529, Chr III from 79161-82274, Verified ORF [yeastflysequest.fasta]
  • Kcc4p [Saccharomyces cerevisiae]gi|14588913|emb|CAC42961.1| kinase [Saccharomyces cerevisiae]gi|32363493|sp|P25389|KCC4_YEAST Probable serine/threonine-protein kinase KCC4 [nrdb_11152004_Chlamydomonas]
  • KCC4 SGDID:S000000529, Chr III from 79161-82274, Verified ORF, "Protein kinase of the bud neck involved in the septin checkpoint, associates with septin proteins, negatively regulates Swe1p by phosphorylation, shows structural homology to bud neck kinases [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta]
  • KCC4 SGDID:S000000529, Chr III from 79162-82275, Verified ORF, "Protein kinase of the bud neck involved in the septin checkpoint, associates with septin proteins, negatively regulates Swe1p by phosphorylation, shows structural homology to bud neck kinases [yeast-contam.fasta]
  • Protein kinase of the bud neck involved in the septin checkpoint, associates with septin proteins, negatively regulates Swe1p by phosphorylation, shows structural homology to bud neck kinases Gin4p and Hsl1p; Kcc4p [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • Probable serine/threonine-protein kinase KCC4 [nr-271106-contam.fasta]
  • kinase [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • KCC4 SGDID:S000000529, Chr III from 79162-82275, Verified ORF, "Protein kinase of the bud neck involved in the septin checkpoint, associates with septin proteins, negatively regulates Swe1p by phosphorylation, shows structural homology to bud neck kinases Gin4p and Hsl1p" [yeast-bovrabprots.fasta]
  • [chemostatdb.fasta]
  • Probable serine/threonine-protein kinase KCC4 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=KCC4 PE=1 SV=3 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta]
  • KCC4 SGDID:S000000529, Chr III from 79162-82275, Genome Release 64-1-1, Verified ORF, "Protein kinase of the bud neck involved in the septin checkpoint, associates with septin proteins, negatively regulates Swe1p by phosphorylation, shows structural homology to bud neck kinases Gin4p and Hsl1p" [yeast-030211-contam.fasta]
  • KCC4 SGDID:S000000529, Chr III from 79162-82275, Genome Release 64-2-1, Verified ORF, "Protein kinase of the bud neck involved in the septin checkpoint; associates with septin proteins, negatively regulates Swe1p by phosphorylation, shows structural homology to bud neck kinases Gin4p and Hsl1p; KCC4 has a paralog, GIN4, that arose from the whole genome duplication" [20141208_orf_trans.fasta]
  • YCL024W SGDID:S000000529, Chr III from 79162-82275, Genome Release 64-1-1, Verified ORF, "Protein kinase of the bud neck involved in the septin checkpoint, associates with septin proteins, negatively regulates Swe1p by phosphorylation, shows structural homology to bud neck kinases Gin4p and Hsl1p" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
    • Organism: Saccharomyces cerevisiae
    Length: 1037 amino acids

    Gene Ontology:
    Cellular Component: cellular bud neck [IDALink to PubMed articleLink to PubMed article]
    Biological Process: axial cellular bud site selection [TASLink to PubMed article]
    septin ring assembly [IGILink to PubMed article][IMPLink to PubMed article]
    protein amino acid phosphorylation [ISSLink to PubMed article]
    budding cell bud growth [IGILink to PubMed article][IMPLink to PubMed article]
    septin checkpoint [IGILink to PubMed article][IMPLink to PubMed article]
    Molecular Function: protein kinase activity [ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTVANTETHS AAKPSSTIGP WKLGETLGFG STGKVQLAQH ERTGHRTAVK VISKSIFNNN  60
   61 GNHSNDDSVL PYNIEREIVI MKLLSHPNVL SLYDVWETNN NLYLILEYAE KGELFNLLVD 120
  121 HGPLPEREAI NCFRQIIIGI SYCHALGIVH RDLKPENLLL DSFYNIKIAD FGMAALQTDA 180
  181 DLLETSCGSP HYAAPEIVSG LPYEGFASDV WSCGVILFAL LTGRLPFDEE NGNVRDLLLK 240
  241 VQKGQFEMPN DTEISRDAQD LIGKILVVDP RQRIKIRDIL SHPLLKKYQT IKDSKSIKDL 300
  301 PRENTYLYPL ADSNNHTSAS IDDSILQNLV VLWHGRHADD IVSKLKENGT NKEKILYALL 360
  361 YRFKLDSVRG SNKKNRNKIK KTKKNKRSST LSSSSSLLLN NRSIQSTPRR RTSKRHSREF 420
  421 SSSRKRSSFL LSSNPTDSSP IPLRSSKRIT HINVASANTQ ATPSGVPNPH KRNSKKRSSK 480
  481 RLSYMPNTKR SSLTSKSLSN FTNLIDDDDW EYIEKDAKRT SSNFATLIDE IFEPEKFELA 540
  541 KREKAELQRK VQEAKRQSVN AQKINEDEFG SEVSDGMKEL KKINDKVSSP LINYEFSQQE 600
  601 LLQDIDTLLT NRYQLSSYTR PISRLDPGLT PVTETLPNNL KEKTALLQDT EKKIIETIRR 660
  661 SKFLGSLLNV RGGLSPGKSE LAPIEESPIV STTPLIYNDR MEPRRISDVE VPHFTRKSKH 720
  721 FTTANNRRSV LSLYAKDSIK DLNEFLIKED PDLPPQGSTD NESRSEDPEI AESITDSRNI 780
  781 QYDEDDSKDG DNVNNDNILS DFPQGVGISQ EYDMKDKNPN QSPISKSAEP TLVVKLPSLS 840
  841 SFQGKNASGL GLYQREPSKV TLPSLTSNNS SVGENIEDGA EKGTESEKIA ASLSDDDLKE 900
  901 DNDKKDNDTV NAPTTVKKPP NSVLLKKFSK GKILELEIHA KIPEKRLYEG LHKLLEGWKQ 960
  961 YGLKNLVFNI TNMIITGKLV NDSILFLRST LFEIMVLPNG DGRSLIKFNK KTGSTKTLTK1020
 1021 LATEIQIILQ KEGVLDK

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) GIN4 HFD1 HTZ1 KAP114 KCC4 NAP1 PRO3 REI1 RIM11 RPS6A, RPS6B UBC8 VIP1 WTM1 YKR011C
    View Details Gavin AC, et al. (2006) GIN4 KCC4
    View Details Gavin AC, et al. (2002) ADH1 GIN4 HMO1 HTZ1 KAP114 KCC4 LYS12 NAP1 NBA1 NIS1 PBP2 PDC1 PGI1 RAD1 RAD10 SSC1 YEF3 YRA1
    View Details Qiu et al. (2008) ELM1 KCC4

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run RPA135 No Comments Schneider, DA, et al. (2006)
    View Run MLP2 #29 Asynchronous Prep5-TiO2 Flowthrough Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data KCC4 Sundin BA, et al. (2004)
    View Data KCC4 Sundin BA, et al. (2004)
    View Data KCC4 Sundin BA, et al. (2004)
    View Data KCC4 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..111]
    [310..396]    		 PSI-BLAST 557.9897 Calmodulin-dependent protein kinase
    2 View Details [112..309] PSI-BLAST 557.9897 Calmodulin-dependent protein kinase
    3 View Details [397..625] deduced N/A No confident structure predictions are available.
    4 View Details [626..918] ORFEUS 7.24 Microbial transglutaminase
    5 View Details [919..1037] deduced N/A Confident ab initio structure predictions are available.
    6 View Details [921..1037] deduced N/A Confident ab initio structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.96

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle