Protein Overview: ARO4

General Information:
Name(s) found:	ARO4 / YBR249C [SGD]
Description(s) found: Found 118 descriptions. SHOW ALL	3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP) synthase, catalyzes the first step in aromatic amino acid biosynthesis and is feedback-inhibited by tyrosine or high concentrations of phenylalanine or tryptophan [SGD]
Organism:	Saccharomyces cerevisiae
Length:	370 amino acids
Gene Ontology:
Cellular Component:	nucleus [IDA] cytoplasm [IDA]
Biological Process:	aromatic amino acid family biosynthetic process [TAS]
Molecular Function:	3-deoxy-7-phosphoheptulonate synthase activity [IDA]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSESPMFAAN GMPKVNQGAE EDVRILGYDP LASPALLQVQ IPATPTSLET AKRGRREAID  60
   61 IITGKDDRVL VIVGPCSIHD LEAAQEYALR LKKLSDELKG DLSIIMRAYL EKPRTTVGWK 120
  121 GLINDPDVNN TFNINKGLQS ARQLFVNLTN IGLPIGSEML DTISPQYLAD LVSFGAIGAR 180
  181 TTESQLHREL ASGLSFPVGF KNGTDGTLNV AVDACQAAAH SHHFMGVTKH GVAAITTTKG 240
  241 NEHCFVILRG GKKGTNYDAK SVAEAKAQLP AGSNGLMIDY SHGNSNKDFR NQPKVNDVVC 300
  301 EQIANGENAI TGVMIESNIN EGNQGIPAEG KAGLKYGVSI TDACIGWETT EDVLRKLAAA 360
  361 VRQRREVNKK

Protein Complex Data

	PUBLICATION	TOPOLOGY	COCOMPLEXED PROTEINS
View Details	Krogan NJ, et al. (2006)		ARO4 CAM1 TEF4 TMA19
View Details	Ho Y, et al. (2002)		ACC1 AHA1 ARO4 CAR2 CDC60 ILS1 LSP1 NAP1 OYE2 PIL1 RPA135 RPA190 RPC40 SMC4 TRP5 URE2 VMA4 YPL150W

Mass Spectrometry Data

The following runs contain data for this protein:

	BAIT	COMMENTS	PUBLICATION
View Run	MLP2	#26 Asynchronous Prep4-TiO2 Phosphopeptide enriched, Steps1-2	Keck JM, et al. (2011)

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

	PROTEIN(S)	PUBLICATION
View Data	ARO4	Huh WK, et al. (2003)

Searching the YRC Public Image Repository, found results:

Currently showing to of results.

[View Search in the YRC Public Image Repository]

Searching the YRC Public Image Repository, found no results.

Ginzu Version Information

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

Gene Ontology predictions

Term	Confidence	Notes
3-deoxy-7-phosphoheptulonate synthase activity	2.72022882819661	bayes_pls_golite062009
catalytic activity	2.67031204377352	bayes_pls_golite062009
lyase activity	0.740424046054758	bayes_pls_golite062009
transferase activity, transferring aldehyde or ketonic groups	0.719960432098845	bayes_pls_golite062009
oxo-acid-lyase activity	0.606352769346285	bayes_pls_golite062009
ligase activity, forming carbon-carbon bonds	0.490222900376021	bayes_pls_golite062009
transferase activity	0.464721888799972	bayes_pls_golite062009
carbon-carbon lyase activity	0.36754360512349	bayes_pls_golite062009
3-deoxy-8-phosphooctulonate synthase activity	0.0356008407895519	bayes_pls_golite062009

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.99

Source: Reynolds et al. (2008)

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..370]	PSI-BLAST	1200.0	3-deoxy-D-arabino-heptulosonate-7-phosphate synthase (DAHP synthase, AroG)

Protein Overview: ARO4

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: