YRC Public Data Repository - Protein Structure Prediction

Protein:	ARO4
Organism:	Saccharomyces cerevisiae
Length:	370 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for ARO4.

Description	E-value	Query Range	Subject Range
ARO4 - 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP) synthase, catalyzes the first step in aromatic am... AROG_YEAST - Phospho-2-dehydro-3-deoxyheptonate aldolase, tyrosine-inhibited OS=Saccharomyces cerevisiae (strain ... gi\|207347493 - gi\|207347493\|gb\|EDZ73646.1\| YBR249Cp-like protein [Saccharomyces cerevisiae AWRI1631] gi\|190408601 - gi\|190408601\|gb\|EDV11866.1\| 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase isoenzyme [Saccharo...	0.0	[1..370]	[1..370]
gi\|11527262 - gi\|11527262\|gb\|AAG36950.1\|AF283009_1 phe-inhibited DAHP synthase [Aspergillus nidulans]	0.0	[4..366]	[2..368]
AROG_ECO57 - Phospho-2-dehydro-3-deoxyheptonate aldolase, Phe-sensitive OS=Escherichia coli O157:H7 GN=aroG PE=3 ... gi\|238859808, gi... - gi\|238900012\|ref\|YP_002925808.1\| 3-deoxy-D-arabino-heptulosonate-7-phosphate synthase, phenylalanine... EG10079 - 3-deoxy-D-arabino-heptulosonate-7-phosphate synthase, phenylalanine repressible / 3-deoxy-D-arabino-... gi\|242376509, gi... - gi\|251784236\|ref\|YP_002998540.1\| hypothetical protein B21_00696 [Escherichia coli BL21], gi\|24237650... gi\|15800463, gi\|... - gi\|15800463\|ref\|NP_286475.1\| phospho-2-dehydro-3-deoxyheptonate aldolase [Escherichia coli O157:H7 E... gi\|253976912, gi... - gi\|254287605\|ref\|YP_003053353.1\| 3-deoxy-D-arabino-heptulosonate-7-phosphate synthase, phenylalanine... AROG_ECOLI - Phospho-2-dehydro-3-deoxyheptonate aldolase, Phe-sensitive (EC 2.5.1.54) (Phospho-2-keto-3-deoxyhept... gi\|253972718, gi... - gi\|254160817\|ref\|YP_003043925.1\| 3-deoxy-D-arabino-heptulosonate-7-phosphate synthase, phenylalanine... gi\|254591304, gi... - gi\|254791904\|ref\|YP_003076741.1\| 3-deoxy-D-arabino-heptulosonate-7-phosphate synthase, phenylalanine... gi\|168750246, gi... - gi\|188015532\|gb\|EDU53654.1\| 3-deoxy-7-phosphoheptulonate synthase, Phe-sensitive [Escherichia coli O... gi\|1651339, gi\|8... - gi\|89107605\|ref\|AP_001385.1\| 3-deoxy-D-arabino-heptulosonate-7-phosphate synthase, phenylalanine rep... gi\|13360241, gi\|... - gi\|15830036\|ref\|NP_308809.1\| phospho-2-dehydro-3-deoxyheptonate aldolase [Escherichia coli O157:H7 s... gi\|168763344, gi... - gi\|189366448\|gb\|EDU84864.1\| 3-deoxy-7-phosphoheptulonate synthase, Phe-sensitive [Escherichia coli O... gi\|168757043, gi... - gi\|189355850\|gb\|EDU74269.1\| 3-deoxy-7-phosphoheptulonate synthase, Phe-sensitive [Escherichia coli O... gi\|187768162, gi... - gi\|187768162\|gb\|EDU32006.1\| 3-deoxy-7-phosphoheptulonate synthase, Phe-sensitive [Escherichia coli O... gi\|189363458, gi... - gi\|189363458\|gb\|EDU81877.1\| 3-deoxy-7-phosphoheptulonate synthase, Phe-sensitive [Escherichia coli O... gi\|189373159, gi... - gi\|189373159\|gb\|EDU91575.1\| 3-deoxy-7-phosphoheptulonate synthase, Phe-sensitive [Escherichia coli O... gi\|168779242, gi... - gi\|189002923\|gb\|EDU71909.1\| 3-deoxy-7-phosphoheptulonate synthase, Phe-sensitive [Escherichia coli O... gi\|81240176, gi\|... - gi\|82776028\|ref\|YP_402375.1\| phospho-2-dehydro-3-deoxyheptonate aldolase [Shigella dysenteriae Sd197... gi\|217326155, gi... - gi\|217326155\|ref\|ZP_03442239.1\| 3-deoxy-7-phosphoheptulonate synthase, Phe-sensitive [Escherichia co... EG10079 - 3-deoxy-D-arabino-heptulosonate-7-phosphate synthase, phenylalanine repressible / 3-deoxy-D-arabino-... gi\|81244585, gi\|... - gi\|82543174\|ref\|YP_407121.1\| phospho-2-dehydro-3-deoxyheptonate aldolase [Shigella boydii Sb227], gi... gi\|209917998, gi... - gi\|209917998\|ref\|YP_002292082.1\| phospho-2-dehydro-3-deoxyheptonate aldolase [Escherichia coli SE11]... gi\|192926766, gi... - gi\|75256338\|ref\|ZP_00728008.1\| COG0722: 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase ... gi\|75511356, gi\|... - gi\|75511356\|ref\|ZP_00734041.1\| COG0722: 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase ... gi\|218694171, gi... - gi\|218694171\|ref\|YP_002401838.1\| phospho-2-dehydro-3-deoxyheptonate aldolase [Escherichia coli 55989... gi\|170020908, gi... - gi\|170020908\|ref\|YP_001725862.1\| phospho-2-dehydro-3-deoxyheptonate aldolase [Escherichia coli ATCC ... gi\|83584861, gi\|... - gi\|83584861\|ref\|ZP_00923520.1\| COG0722: 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase ... gi\|168800814, gi... - gi\|189376981\|gb\|EDU95397.1\| 3-deoxy-7-phosphoheptulonate synthase, Phe-sensitive [Escherichia coli O... gi\|195936742 - gi\|195936742\|ref\|ZP_03082124.1\| phospho-2-dehydro-3-deoxyheptonate aldolase [Escherichia coli O157:H... gi\|170080414, gi... - gi\|170080414\|ref\|YP_001729734.1\| 3-deoxy-D-arabino-heptulosonate-7-phosphate synthase, phenylalanine... gi\|194412266, gi... - gi\|75209077\|ref\|ZP_00709335.1\| COG0722: 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase ... gi\|208731490, gi... - gi\|208814842\|ref\|ZP_03256021.1\| 3-deoxy-7-phosphoheptulonate synthase, Phe-sensitive [Escherichia co... gi\|75228379, gi\|... - gi\|75228379\|ref\|ZP_00715027.1\| COG0722: 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase ... gi\|208808417, gi... - gi\|208808417\|ref\|ZP_03250754.1\| 3-deoxy-7-phosphoheptulonate synthase, Phe-sensitive [Escherichia co... gi\|187427742, gi... - gi\|75175250\|ref\|ZP_00695560.1\| COG0722: 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase ... gi\|124531871, gi... - gi\|124531871\|ref\|ZP_01701970.1\| phospho-2-dehydro-3-deoxyheptonate aldolase [Escherichia coli B], gi... gi\|209400570, gi... - gi\|209400570\|ref\|YP_002269381.1\| 3-deoxy-7-phosphoheptulonate synthase, Phe-sensitive [Escherichia c... gi\|75194907, gi\|... - gi\|75194907\|ref\|ZP_00704977.1\| COG0722: 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase ... gi\|208737562, gi... - gi\|208822077\|ref\|ZP_03262396.1\| 3-deoxy-7-phosphoheptulonate synthase, Phe-sensitive [Escherichia co...	0.0	[19..365]	[4..349]
gi\|205327720, gi... - gi\|205327720\|gb\|EDZ14484.1\| 3-deoxy-7-phosphoheptulonate synthase, Phe-sensitive [Salmonella enteric... gi\|197290090, gi... - gi\|197290090\|gb\|EDY29447.1\| 3-deoxy-7-phosphoheptulonate synthase, Phe-sensitive [Salmonella enteric... gi\|161364372, gi... - gi\|161615008\|ref\|YP_001588973.1\| phospho-2-dehydro-3-deoxyheptonate aldolase [Salmonella enterica su... lcl\|NC_016856.1_... - [gene=aroG] [protein=phospho-2-dehydro-3-deoxyheptonate aldolase] [protein_id=YP_005236479.2] [locat... gi\|199602771, gi... - gi\|200390326\|ref\|ZP_03216937.1\| 3-deoxy-7-phosphoheptulonate synthase, Phe-sensitive [Salmonella ent... gi\|194734297, gi... - gi\|194734297\|ref\|YP_002113862.1\| 3-deoxy-7-phosphoheptulonate synthase, Phe-sensitive [Salmonella en... gi\|16764125, gi\|... - gi\|16764125\|ref\|NP_459740.1\| phospho-2-dehydro-3-deoxyheptonate aldolase [Salmonella typhimurium LT2... gi\|197248245, gi... - gi\|197248245\|ref\|YP_002145716.1\| 3-deoxy-7-phosphoheptulonate synthase, Phe-sensitive [Salmonella en...	0.0	[19..365]	[4..349]
gi\|224467101, gi... - gi\|224582574\|ref\|YP_002636372.1\| 3-deoxy-7-phosphoheptulonate synthase [Salmonella enterica subsp. e... gi\|213649740 - gi\|213649740\|ref\|ZP_03379793.1\| phospho-2-dehydro-3-deoxyheptonate aldolase [Salmonella enterica sub... gi\|197264402, gi... - gi\|197264402\|ref\|ZP_03164476.1\| 3-deoxy-7-phosphoheptulonate synthase, Phe-sensitive [Salmonella ent... gi\|194470112, gi... - gi\|194470112\|ref\|ZP_03076096.1\| 3-deoxy-7-phosphoheptulonate synthase, Phe-sensitive [Salmonella ent... gi\|194447367, gi... - gi\|194447367\|ref\|YP_002044789.1\| phospho-2-dehydro-3-deoxyheptonate aldolase [Salmonella enterica su... gi\|194404569, gi... - gi\|194445906\|ref\|YP_002039996.1\| 3-deoxy-7-phosphoheptulonate synthase, Phe-sensitive [Salmonella en... gi\|213427703 - gi\|213427703\|ref\|ZP_03360453.1\| phospho-2-dehydro-3-deoxyheptonate aldolase [Salmonella enterica sub... gi\|213163244 - gi\|213163244\|ref\|ZP_03348954.1\| phospho-2-dehydro-3-deoxyheptonate aldolase [Salmonella enterica sub... gi\|206708002, gi... - gi\|207856199\|ref\|YP_002242850.1\| phospho-2-dehydro-3-deoxyheptonate aldolase [Salmonella enterica su... gi\|197939792, gi... - gi\|198245276\|ref\|YP_002214725.1\| 3-deoxy-7-phosphoheptulonate synthase, Phe-sensitive [Salmonella en... gi\|205334730, gi... - gi\|205334730\|gb\|EDZ21494.1\| 3-deoxy-7-phosphoheptulonate synthase, Phe-sensitive [Salmonella enteric... gi\|205324476, gi... - gi\|205324476\|gb\|EDZ12315.1\| 3-deoxy-7-phosphoheptulonate synthase, Phe-sensitive [Salmonella enteric... gi\|162139602 - gi\|162139602\|ref\|YP_215746.2\| phospho-2-dehydro-3-deoxyheptonate aldolase [Salmonella enterica subsp... gi\|29138164, gi\|... - gi\|29142533\|ref\|NP_805875.1\| phospho-2-dehydro-3-deoxyheptonate aldolase [Salmonella enterica subsp.... gi\|205343148, gi... - gi\|205343148\|gb\|EDZ29912.1\| 3-deoxy-7-phosphoheptulonate synthase, Phe-sensitive [Salmonella enteric... gi\|16759694 - gi\|16759694\|ref\|NP_455311.1\| phospho-2-dehydro-3-deoxyheptonate aldolase [Salmonella enterica subsp.... gi\|168468100, gi... - gi\|195628821\|gb\|EDX48243.1\| 3-deoxy-7-phosphoheptulonate synthase, Phe-sensitive [Salmonella enteric... gi\|205347179, gi... - gi\|205347179\|gb\|EDZ33810.1\| 3-deoxy-7-phosphoheptulonate synthase, Phe-sensitive [Salmonella enteric... gi\|25291146, gi\|... - gi\|25291146\|pir\|\|AG0593 phospho-2-dehydro-3-deoxyheptonate aldolase (DAHP synthetase) phenylalanine ... gi\|168240614, gi... - gi\|205340111\|gb\|EDZ26875.1\| 3-deoxy-7-phosphoheptulonate synthase, Phe-sensitive [Salmonella enteric...	0.0	[19..365]	[4..349]
gi\|170081363, gi... - gi\|170081363\|ref\|YP_001730683.1\| 3-deoxy-D-arabino-heptulosonate-7-phosphate synthase, tryptophan re... gi\|238859809, gi... - gi\|238900919\|ref\|YP_002926715.1\| 3-deoxy-D-arabino-heptulosonate-7-phosphate synthase, tryptophan re... gi\|242377428, gi... - gi\|251785155\|ref\|YP_002999459.1\| hypothetical protein B21_01662 [Escherichia coli BL21], gi\|24237742... gi\|253977859, gi... - gi\|254288552\|ref\|YP_003054300.1\| 3-deoxy-D-arabino-heptulosonate-7-phosphate synthase, tryptophan re... gi\|253973665, gi... - gi\|254161764\|ref\|YP_003044872.1\| 3-deoxy-D-arabino-heptulosonate-7-phosphate synthase, tryptophan re... gi\|1742785, gi\|8... - gi\|89108544\|ref\|AP_002324.1\| 3-deoxy-D-arabino-heptulosonate-7-phosphate synthase, tryptophan repres... AROH_ECOLI - Phospho-2-dehydro-3-deoxyheptonate aldolase, Trp-sensitive (EC 2.5.1.54) (Phospho-2-keto-3-deoxyhept... gi\|194438496, gi... - gi\|83586008\|ref\|ZP_00924646.1\| COG0722: 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase ... gi\|191167852, gi... - gi\|75228985\|ref\|ZP_00715572.1\| COG0722: 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase ... EG10080 - 3-deoxy-D-arabino-heptulosonate-7-phosphate synthase, tryptophan repressible / 3-deoxy-D-arabino-hep... EG10080 - 3-deoxy-D-arabino-heptulosonate-7-phosphate synthase, tryptophan repressible / 3-deoxy-D-arabino-hep... gi\|188495673, gi... - gi\|75513795\|ref\|ZP_00736171.1\| COG0722: 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase ...	0.0	[19..364]	[3..347]
gi\|12720830, gi\|... - gi\|15602428\|ref\|NP_245500.1\| phospho-2-dehydro-3-deoxyheptonate aldolase [Pasteurella multocida subs...	0.0	[20..369]	[12..361]
AROG_HAEIN - Phospho-2-dehydro-3-deoxyheptonate aldolase OS=Haemophilus influenzae (strain ATCC 51907 / DSM 11121... AROG_HAEIN - Phospho-2-dehydro-3-deoxyheptonate aldolase OS=Haemophilus influenzae GN=aroG PE=3 SV=1	0.0	[20..367]	[12..359]
gi\|170081363, gi... - gi\|170081363\|ref\|YP_001730683.1\| 3-deoxy-D-arabino-heptulosonate-7-phosphate synthase, tryptophan re... gi\|238859809, gi... - gi\|238900919\|ref\|YP_002926715.1\| 3-deoxy-D-arabino-heptulosonate-7-phosphate synthase, tryptophan re... gi\|242377428, gi... - gi\|251785155\|ref\|YP_002999459.1\| hypothetical protein B21_01662 [Escherichia coli BL21], gi\|24237742... gi\|253977859, gi... - gi\|254288552\|ref\|YP_003054300.1\| 3-deoxy-D-arabino-heptulosonate-7-phosphate synthase, tryptophan re... gi\|253973665, gi... - gi\|254161764\|ref\|YP_003044872.1\| 3-deoxy-D-arabino-heptulosonate-7-phosphate synthase, tryptophan re... gi\|1742785, gi\|8... - gi\|89108544\|ref\|AP_002324.1\| 3-deoxy-D-arabino-heptulosonate-7-phosphate synthase, tryptophan repres... AROH_ECOLI - Phospho-2-dehydro-3-deoxyheptonate aldolase, Trp-sensitive (EC 2.5.1.54) (Phospho-2-keto-3-deoxyhept... gi\|194438496, gi... - gi\|83586008\|ref\|ZP_00924646.1\| COG0722: 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase ... gi\|191167852, gi... - gi\|75228985\|ref\|ZP_00715572.1\| COG0722: 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase ... EG10080 - 3-deoxy-D-arabino-heptulosonate-7-phosphate synthase, tryptophan repressible / 3-deoxy-D-arabino-hep... EG10080 - 3-deoxy-D-arabino-heptulosonate-7-phosphate synthase, tryptophan repressible / 3-deoxy-D-arabino-hep... gi\|188495673, gi... - gi\|75513795\|ref\|ZP_00736171.1\| COG0722: 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase ...	0.0	[19..364]	[3..347]

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Predicted Domain #1

Region A:
Residues: [1-370]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSESPMFAAN GMPKVNQGAE EDVRILGYDP LASPALLQVQ IPATPTSLET AKRGRREAID  60
   61 IITGKDDRVL VIVGPCSIHD LEAAQEYALR LKKLSDELKG DLSIIMRAYL EKPRTTVGWK 120
  121 GLINDPDVNN TFNINKGLQS ARQLFVNLTN IGLPIGSEML DTISPQYLAD LVSFGAIGAR 180
  181 TTESQLHREL ASGLSFPVGF KNGTDGTLNV AVDACQAAAH SHHFMGVTKH GVAAITTTKG 240
  241 NEHCFVILRG GKKGTNYDAK SVAEAKAQLP AGSNGLMIDY SHGNSNKDFR NQPKVNDVVC 300
  301 EQIANGENAI TGVMIESNIN EGNQGIPAEG KAGLKYGVSI TDACIGWETT EDVLRKLAAA 360
  361 VRQRREVNKK

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	1200.0
Match:	1gg1A_
Description:	3-deoxy-D-arabino-heptulosonate-7-phosphate synthase (DAHP synthase, AroG)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
3-deoxy-7-phosphoheptulonate synthase activity	2.72022882819661	bayes_pls_golite062009
catalytic activity	2.67031204377352	bayes_pls_golite062009
lyase activity	0.740424046054758	bayes_pls_golite062009
transferase activity, transferring aldehyde or ketonic groups	0.719960432098845	bayes_pls_golite062009
oxo-acid-lyase activity	0.606352769346285	bayes_pls_golite062009
ligase activity, forming carbon-carbon bonds	0.490222900376021	bayes_pls_golite062009
transferase activity	0.464721888799972	bayes_pls_golite062009
carbon-carbon lyase activity	0.36754360512349	bayes_pls_golite062009
3-deoxy-8-phosphooctulonate synthase activity	0.0356008407895519	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: