Protein Overview: MCX1

General Information:
Name(s) found:	MCX1 / YBR227C [SGD]
Description(s) found: SHOW ONLY BEST	gi\|6319704\|ref\|NP_009786.1\| Mitochondrial ATP-binding protein, possibly a mitochondrial chaperone with non-proteolytic function; similar to bacterial ClpX proteins; Mcx1p [Saccharomyces cerevisiae] [NCBI NR] pir\|\|S46103 ATP-binding protein clpX, mitochondrial - yeast (Saccharomyces cerevisiae) [NCBI NR] gi\|586344\|sp\|P38323.1\|MCX1_YEAST RecName: Full=Mitochondrial clpX-like chaperone MCX1 [NCBI NR] gi\|536622\|emb\|CAA85190.1\| unnamed protein product [Saccharomyces cerevisiae] [NCBI NR] Mitochondrial clpX-like chaperone MCX1 OS=Saccharomyces cerevisiae GN=MCX1 PE=1 SV=1 [Swiss-Prot] MCX1 Mitochondrial ATP-binding protein [mips] Mitochondrial matrix protein; putative ATP-binding chaperone with non-proteolytic function; similar to bacterial ClpX proteins [SGD] MCX1, Chr II from 673530-675092, reverse complement [yeast_orfs2] Chr II from 673530-675092, reverse complement [yeastorf3.fasta] Chr II from 673529-675091, reverse complement [yeastorf4.fasta] Chr II from 675089-673527, reverse complement [yeastorf5.fasta] (P38323) Mitochondrial clpX-like chaperone MCX1 [4932.FASTACCERV.txt] MCX1 SGDID:S0000431, Chr II from 675091-673529, reverse complement, Verified ORF [yeastflysequest.fasta] MCX1 SGDID:S0000431, Chr II from 675129-673567, reverse complement, Verified ORF [10112005cervSGD.fasta] Mcx1p [Saccharomyces cerevisiae]gi\|536622\|emb\|CAA85190.1\| unnamed protein product [Saccharomyces cerevisiae]gi\|626103\|pir\|\|S46103 ATP-binding protein clpX, mitochondrial - yeast (Saccharomyces cerevisiae)gi\|586344\|sp\|P38323\|MCX1_YEAST Mitochondrial cl [nrdb_11152004_Chlamydomonas] MCX1 SGDID:S000000431, Chr II from 675129-673567, reverse complement, Verified ORF, "Mitochondrial ATP-binding protein, possibly a mitochondrial chaperone with non-proteolytic function; similar to bacterial ClpX proteins" [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta] MCX1 SGDID:S000000431, Chr II from 675129-673567, reverse complement, Verified ORF, "Mitochondrial matrix protein; putative ATP-binding chaperone with non-proteolytic function; similar to bacterial ClpX proteins" [yeast-200209-contam.fasta] Mitochondrial clpX-like chaperone MCX1 [nr-271106-contam.fasta] Mitochondrial ATP-binding protein, possibly a mitochondrial chaperone with non-proteolytic function; similar to bacterial ClpX proteins; Mcx1p [Saccharomyces cerevisiae] [nr-271106-contam.fasta] unnamed protein product [Saccharomyces cerevisiae] [nr-271106-contam.fasta] [chemostatdb.fasta] Mitochondrial clpX-like chaperone MCX1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=MCX1 PE=1 SV=1 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta] MCX1 SGDID:S000000431, Chr II from 675134-673572, Genome Release 64-1-1, reverse complement, Verified ORF, "Mitochondrial matrix protein; putative ATP-binding chaperone with non-proteolytic function; similar to bacterial ClpX proteins" [yeast-030211-contam.fasta] MCX1 SGDID:S000000431, Chr II from 675134-673572, Genome Release 64-2-1, reverse complement, Verified ORF, "Mitochondrial matrix protein; putative ATP-binding chaperone with non-proteolytic function; similar to bacterial ClpX proteins" [20141208_orf_trans.fasta] YBR227C SGDID:S000000431, Chr II from 675134-673572, Genome Release 64-1-1, reverse complement, Verified ORF, "Mitochondrial matrix protein; putative ATP-binding chaperone with non-proteolytic function; similar to bacterial ClpX proteins" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta] ATP-dependent clpX-like chaperone, mitochondrial OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=MCX1 PE=1 SV=1 [uniprot_sprot.fasta.20160308]
Organism:	Saccharomyces cerevisiae
Length:	520 amino acids
Gene Ontology:
Cellular Component:	mitochondrial matrix [IDA] mitochondrion [IDA]
Biological Process:	biological_process [ND]
Molecular Function:	ATP binding [ISS] unfolded protein binding [TAS]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLKSASQNFF RAYSSRIGRY AATASGKLAQ SRLSNIPTPK ALKKFLDEYI VGQEIGKKVL  60
   61 SVAVYNHYLR INDKQKKGEL QRQRELMERE KIADDRDEPI FSGNSESKAG WRNLQRQFNL 120
  121 AGREVDEDLE LSKSNVLVVG PSGSGKTLLA TTLAKILNVP IAITDCTQLT QAGYIGEDVE 180
  181 VCIERLLVNA EFDVARAEKG IIVLDEIDKL AKPAASIGTK DVSGEGVQQS LLKIIEGHKV 240
  241 EITVKRPVKH DIDGQKNQTT TKKDEVFVVD TSNILFMIMG AFVGLDKHIV KRIEDMKKIQ 300
  301 KAGESVESSN SKEVEKERAK KFRFSNTLEQ VELDNGKKVC ALDLTTPTDL VSFGLIPELI 360
  361 GRVPIITALQ PLQRDDLFHI LKEPKNALLD QYEYIFKQFG VRLCVTQKAL KKVAQFALKE 420
  421 GTGARGLRGI MERLLLNVNY DCPGSNIAYV LIDEATVDSL QETEHSLASQ VDVKYYSGDE 480
  481 KDSLIRDVSE EDKKLGVMLE KELGHSANIH TPTIPKRSLT

Protein Complex Data

	PUBLICATION	TOPOLOGY	COCOMPLEXED PROTEINS
View Details	Ho Y, et al. (2002)		BGL2 CBP6 CDC15 DUG2 FRS2 GCD11 GCN3 HXT7 MCX1 NDE1 NMD3 NPA3 PET10 PET9 PST2 SAR1 SLC1 TEM1 TRP3 TRP5 VPS8 YHR033W YNK1

Mass Spectrometry Data

The following runs contain data for this protein:

	BAIT	COMMENTS	PUBLICATION
View Run	BOI2	Boi 2 gst control	McCusker D, et al (2007)

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

	BAIT	PREY	HITS	PUBLICATION
View Screen	CTF13	MCX1	1	Unpublished Fields Lab Data
View Screen	APC5	MCX1	1	Unpublished Fields Lab Data

Microscopy / Localization Data

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	PROTEIN(S)	PUBLICATION
View Data	MCX1	Huh WK, et al. (2003)

Protein Structure Data

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[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..520]	PSI-BLAST	259.9897	HslU

Functions predicted (by domain):

Gene Ontology predictions

Term	Confidence	Notes
hydrolase activity	2.55157966585974	bayes_pls_golite062009
binding	1.62320027057768	bayes_pls_golite062009
catalytic activity	1.00104173493322	bayes_pls_golite062009
purine nucleotide binding	0.569910969126728	bayes_pls_golite062009
purine ribonucleotide binding	0.568840867400671	bayes_pls_golite062009
ribonucleotide binding	0.568779924702229	bayes_pls_golite062009
nucleotide binding	0.564275755355315	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides	0.546796591575762	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	0.543610140926125	bayes_pls_golite062009
pyrophosphatase activity	0.540750418412449	bayes_pls_golite062009
nucleoside-triphosphatase activity	0.517457589081898	bayes_pls_golite062009
nucleic acid binding	0.318452816722389	bayes_pls_golite062009
ATP binding	0.1860481660648	bayes_pls_golite062009
adenyl ribonucleotide binding	0.152859582615242	bayes_pls_golite062009
adenyl nucleotide binding	0.138615225841109	bayes_pls_golite062009
helicase activity	0.0450969969658499	bayes_pls_golite062009

Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

Philius Transmembrane Prediction:

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.94

Source: Reynolds et al. (2008)

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2