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Protein Overview: Ih-PE

General Information:
Name(s) found: Ih-PE / FBpp0099780 [FlyBase]
Description(s) found:
Found 16 descriptions.
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  • The gene I<down>h</down> channel is referred to in FlyBase by the symbol Dmel\Ih (CG8585, FBgn0028428). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:10166938..10186413. It has the cytological map location 50E6-50F1. Based on sequence similarity, it is predicted to have molecular function</span>: intracellular cyclic nucleotide activated cation channel activity; voltage-gated ion channel activity. An electronic pipeline based on InterPro domains suggests that it is involved in the biological process</span>: transmembrane transport; potassium ion transport. 5 alleles are reported. No phenotypic data is available. It has 7 annotated transcripts and 7 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 1327 amino acids

    Gene Ontology:
    Cellular Component: membrane [IEA]
    plasma membrane [ISS]
    Biological Process: potassium ion transport [IEA]
    transmembrane transport [IEA]
    Molecular Function: voltage-gated potassium channel activity [IEA]
    voltage-gated ion channel activity [ISS][NAS]
    intracellular cyclic nucleotide activated cation channel activity [ISS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MHVKHTQRRV SGPGAFGTFT NDQRASRDNL CPDNQQQQQQ RHSHSHQHLV RQSLVSLSNG  60
   61 QPAASAAPDS VSLLRAGDDQ QQHPQQPHLQ QQQQQQQHLQ QQQQRHRSSS SRLSTSGISK 120
  121 QNSSDSRSGL RILDSSHSPV SCGTQSVSST GGQSALYDAC HEYSRSLSAA AAEGAASLLK 180
  181 SHYSDQQLAQ TEPDPEPDPE RDRDRDRDRD RDRERERRHL TNLNLNLSSE YDYSGSDKQQ 240
  241 LVNETYIFKC IANSPSFLRT NKIKEQSKKL RNLSLKTRTA KKKGQIISKS NAVSDNSLHP 300
  301 GDKYLNLYLV EKKHSLQPQV ASTSSSINTT HPQASSAPAS SSSTCTKAPQ LPALSAVAAR 360
  361 QQQLLLNGSL KGKGQSQSQG QSRQTLPGHR ASVRSESGSG SSHTIPATGK SPPVPHSLAA 420
  421 KISSSASGSK NCNLLSASSN SCHKLNAHAQ GSGAGSGSGS GSGSGPPGHS HYAAASPKSS 480
  481 VSSNGHLNKY CLTDLTRRKA EFNRQLSAPT DYTHHSSSNG SQQEGSSEAN EGHEPVGEST 540
  541 ITVASAGVSY PHPYSYPYHY AHHASSATAP ANLKASLQLH SFGSHHPCPY PARPTSTSCT 600
  601 NSFNRRHIRR HKGKLGDRLL SGDSEESVRC SYCSVLNVND NDLRISFENT CTDSLVTAFD 660
  661 DEALLICDQG TEMVHFDDVS LYGTPKEEPM PNIPIVSEKV SANFLKSQLQ SWFQPTDNRL 720
  721 AMKLFGSRKA LVKERIRQKT SGHWVIHPCS SFRFYWDLCM LLLLVANLII LPVAISFFND 780
  781 DLSTRWIAFN CLSDTIFLID IVVNFRTGIM QQDNAEQVIL DPKLIAKHYL RTWFFLDLIS 840
  841 SIPLDYIFLI FNQIMKLQDF SDSFQILHAG RALRILRLAK LLSLVRLLRL SRLVRYVSQW 900
  901 EEVYILQNLQ KKSADRRGRM NRKDKDGLTK SNLILKFLNM ASVFMRIFNL ICMMLLIGHW 960
  961 SGCLQFLVPM LQGFPSNSWV SINELQESYW LEQYSWALFK AMSHMLCIGY GRFPPQSLTD1020
 1021 MWLTMLSMIS GATCYALFLG HATNLIQSLD SSRRQYREKV KQVEEYMAYR KLPRDMRQRI1080
 1081 TEYFEHRYQG KFFDEELILG ELSEKLREDV INYNCRSLVA SVPFFANADS NFVSDVVTKL1140
 1141 KYEVFQPGDI IIKEGTIGTK MYFIQEGVVD IVMANGEVAT SLSDGSYFGE ICLLTNARRV1200
 1201 ASVRAETYCN LFSLSVDHFN CVLDQYPLMR KTMETVAAER LNKIGKNPNI MHQKDEQLSN1260
 1261 PESNTITAVV NALAAEADDC KDDDMDLKEN LLHGSESSIA EPVQTIREGL PRPRSGEFRA1320
 1321 LFEGNTP

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..115] deduced N/A No confident structure predictions are available.
    2 View Details [116..336] deduced N/A No confident structure predictions are available.
    3 View Details [337..465] deduced N/A No confident structure predictions are available.
    4 View Details [466..518] deduced N/A No confident structure predictions are available.
    5 View Details [519..595] deduced N/A No confident structure predictions are available.
    6 View Details [596..1015] PSI-BLAST 4.39794 No description for 2nyyA was found.
    7 View Details [1016..1246] PSI-BLAST 36.0 HCN2J 443-645 in the presence of cGMP
    8 View Details [1247..1327] PSI-BLAST 17.0 Crystal Structure of Rp-cAMP Binding R1a Subunit of cAMP-dependent Protein Kinase

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3 No functions predicted.
    4 No functions predicted.
    5 No functions predicted.
    6
    Term Confidence Notes
  • amine binding
    		•  1.56690065078434 bayes_pls_golite062009
  • binding
    		•  1.31086473286665 bayes_pls_golite062009
  • transporter activity
    		•  0.883938295782649 bayes_pls_golite062009
  • carbohydrate binding
    		•  0.703854404841118 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  0.698240496790323 bayes_pls_golite062009
  • protein binding
    		•  0.505130802921086 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.481025719380392 bayes_pls_golite062009
  • sugar binding
    		•  0.466177845826757 bayes_pls_golite062009
  • receptor activity
    		•  0.256839032951381 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  0.248374734969893 bayes_pls_golite062009
  • signal transducer activity
    		•  0.149715597443623 bayes_pls_golite062009
  • molecular transducer activity
    		•  0.149715597443623 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  0.0106003018506309 bayes_pls_golite062009
    7
    Term Confidence Notes
  • intracellular cyclic nucleotide activated cation channel activity
    		•  11.4016635726548 bayes_pls_golite062009
  • cyclic nucleotide-gated ion channel activity
    		•  11.4016635726548 bayes_pls_golite062009
  • intracellular ligand-gated ion channel activity
    		•  11.0380255638103 bayes_pls_golite062009
  • intracellular cGMP activated cation channel activity
    		•  9.19973076787954 bayes_pls_golite062009
  • cGMP binding
    		•  7.7575871125398 bayes_pls_golite062009
  • ion channel activity
    		•  7.64606920655297 bayes_pls_golite062009
  • passive transmembrane transporter activity
    		•  7.59395590157869 bayes_pls_golite062009
  • channel activity
    		•  7.59395590157869 bayes_pls_golite062009
  • substrate-specific channel activity
    		•  7.57634767761298 bayes_pls_golite062009
  • cation channel activity
    		•  7.48229936274058 bayes_pls_golite062009
  • ligand-gated channel activity
    		•  7.44819644778429 bayes_pls_golite062009
  • ligand-gated ion channel activity
    		•  7.44819644778429 bayes_pls_golite062009
  • cyclic nucleotide binding
    		•  7.37322432929433 bayes_pls_golite062009
  • gated channel activity
    		•  7.35685244969057 bayes_pls_golite062009
  • metal ion transmembrane transporter activity
    		•  7.0348537556435 bayes_pls_golite062009
  • GMP binding
    		•  5.49455172024846 bayes_pls_golite062009
  • voltage-gated ion channel activity
    		•  4.72292819688752 bayes_pls_golite062009
  • voltage-gated channel activity
    		•  4.69973028985609 bayes_pls_golite062009
  • potassium channel activity
    		•  3.23703259983923 bayes_pls_golite062009
  • voltage-gated cation channel activity
    		•  2.92456251340287 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  2.92372539567194 bayes_pls_golite062009
  • transporter activity
    		•  2.8998330876169 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  2.89477800653409 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  2.8926771958768 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  2.85192191539872 bayes_pls_golite062009
  • cation transmembrane transporter activity
    		•  2.55771040353717 bayes_pls_golite062009
  • voltage-gated potassium channel activity
    		•  2.46282462455194 bayes_pls_golite062009
  • binding
    		•  1.14074551098763 bayes_pls_golite062009
  • protein binding
    		•  0.560659365968498 bayes_pls_golite062009
  • signal transducer activity
    		•  0.202809682876964 bayes_pls_golite062009
  • molecular transducer activity
    		•  0.202809682876964 bayes_pls_golite062009
    8 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
    YRC Informatics Platform - Version 3.0
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