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Protein Overview: dhs-3

General Information:
Name(s) found: dhs-3 / CE41004 [WormBase]
Description(s) found:
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  • WBGene00000967 locus:dhs-3 status:Confirmed UniProt:A5JYX4 protein_id:CAN86610.1 [WormBase]
  • gi|193203115|ref|NP_001122508.1| DeHydrogenases, Short chain family member (dhs-3) [Caenorhabditis elegans] [NCBI NR]
  • gi|148472972|emb|CAN86610.1| C. elegans protein T02E1.5a, partially confirmed by transcript evidence [Caenorhabditis elegans] [NCBI NR]
  • [wormpep130-phg-ecoli-orf-rand.fasta]
  • CE41004 WBGene00000967 locus:dhs-3 3-oxoacyl-[acyl-carrier protein] reductase status:Partially_confirmed UniProt:A5JYX4_CAEEL protein_id:CAN86610.1 [WormBase_C-elegans_193_07-31-2008_con_reversed.fasta]
  • CE41004 WBGene00000967 locus:dhs-3 3-oxoacyl-[acyl-carrier protein] reductase status:Partially_confirmed UniProt:A5JYX4_CAEEL protein_id:CAN86610.1| [wormORF-contam.fasta]
  • [wormORF-contam.fasta]
  • CE41004 WBGene00000967 locus:dhs-3 3-oxoacyl-[acyl-carrier protein] reductase status:Partially_confirmed TR:A5JYX4 protein_id:CAN86610.1 [WormBase_C-elegans_wp180_08-19-2007_reversed.fasta]
  • CE41004 WBGene00000967 locus:dhs-3 3-oxoacyl-[acyl-carrier protein] reductase status:Partially_confirmed UniProt:A5JYX4 protein_id:CAN86610.1 [wormbase_c-elegans_2.11_01-10-2010_reversed.fasta]
  • CE41004 WBGene00000967 locus:dhs-3 3-oxoacyl-[acyl-carrier protein] reductase status:Confirmed UniProt:A5JYX4 protein_id:CAN86610.1 [wormbase_c_elegans_ws231_03-13-2012_reversed.fasta]
  • CE41004 WBGene00000967 locus:dhs-3 status:Confirmed UniProt:A5JYX4 protein_id:CAN86610.1 [wormpep246-ecoli-contam.fasta]
  • Isoform of A5JYX5, DeHydrogenases, Short chain OS=Caenorhabditis elegans GN=dhs-3 PE=1 SV=1 [CAEEL.fasta.20160308]
    • Organism: Caenorhabditis elegans
    Length: 307 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [IEALink to PubMed article]
    Biological Process: estrogen biosynthetic process [IEALink to PubMed article]
    tetrahydrobiopterin biosynthetic process [IEALink to PubMed article]
    poly-hydroxybutyrate biosynthetic process [IEALink to PubMed article]
    embryonic development ending in birth or egg hatching [IMPLink to PubMed article]
    metabolic process [IEALink to PubMed article]
    fatty acid biosynthetic process [IEALink to PubMed article]
    Molecular Function: estradiol 17-beta-dehydrogenase activity [IEALink to PubMed article]
    sepiapterin reductase activity [IEALink to PubMed article]
    3-oxoacyl-[acyl-carrier-protein] reductase activity [IEALink to PubMed article]
    oxidoreductase activity [IEALink to PubMed article]
    NAD or NADH binding [IEALink to PubMed article]
    3-hydroxybutyrate dehydrogenase activity [IEALink to PubMed article]
    acetoacetyl-CoA reductase activity [IEALink to PubMed article]
    2-deoxy-D-gluconate 3-dehydrogenase activity [IEALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MQDILESVVV TLHAICLLII STIRNCFPMG WLLRKDVRGQ TVLITGSGSG LGRLMAFEFG  60
   61 KLGARLVLWD INEQGNKETL KELEAMGVEA KAYTVDLSEY KEINRTADLV KSEVGKVDIL 120
  121 VNNAGIVTGK KLLQCPDELM VKTVSVNTNA LFFTTKNFLP GMLESNKGHI VTIASMAGKC 180
  181 GVAGLVDYCA SKHGAVGFND SLASELYALK KDVKTTVVCP IYINTGMFDG IATKWPTLLP 240
  241 ILSPEYVVDC IMEAVLTDRA FLAIPKFSYI FIALAGLLPT EVLNLYGDHF GITHSMDHFK 300
  301 GRQSRQA

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..307] PSI-BLAST 44.69897 Crystal structure of human 17-beta-hydroxysteroid dehydrogenase type XI

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • retinol dehydrogenase activity
    		•  4.1750549780559 bayes_pls_golite062009
  • oxidoreductase activity
    		•  3.09625241707629 bayes_pls_golite062009
  • oxidoreductase activity, acting on NADH or NADPH, quinone or similar compound as acceptor
    		•  2.344389379767 bayes_pls_golite062009
  • alcohol dehydrogenase (NAD) activity
    		•  2.13179384627038 bayes_pls_golite062009
  • ethanol binding
    		•  2.01597876952325 bayes_pls_golite062009
  • retinol binding
    		•  1.92497267707609 bayes_pls_golite062009
  • catalytic activity
    		•  1.79741889688267 bayes_pls_golite062009
  • steroid dehydrogenase activity
    		•  1.75109362865449 bayes_pls_golite062009
  • oxidoreductase activity, acting on CH-OH group of donors
    		•  1.65338499044318 bayes_pls_golite062009
  • steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
    		•  1.55012034958204 bayes_pls_golite062009
  • alcohol binding
    		•  1.51091775360793 bayes_pls_golite062009
  • oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
    		•  1.47309297191111 bayes_pls_golite062009
  • 3-alpha(17-beta)-hydroxysteroid dehydrogenase (NAD+) activity
    		•  1.42175262136734 bayes_pls_golite062009
  • fatty acid synthase activity
    		•  1.23679054027553 bayes_pls_golite062009
  • benzaldehyde dehydrogenase activity
    		•  1.05577641583555 bayes_pls_golite062009
  • monovalent inorganic cation transmembrane transporter activity
    		•  1.05064033662208 bayes_pls_golite062009
  • receptor activity
    		•  1.02559644924534 bayes_pls_golite062009
  • oxidoreductase activity, acting on NADH or NADPH
    		•  1.01627645289834 bayes_pls_golite062009
  • binding
    		•  0.982999356179965 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  0.973650203491298 bayes_pls_golite062009
  • all-trans retinal binding
    		•  0.968189751942231 bayes_pls_golite062009
  • NADPH:quinone reductase activity
    		•  0.955727553358398 bayes_pls_golite062009
  • signal transducer activity
    		•  0.832324207538104 bayes_pls_golite062009
  • molecular transducer activity
    		•  0.832324207538104 bayes_pls_golite062009
  • oxidoreductase activity, acting on the CH-CH group of donors
    		•  0.62461633437589 bayes_pls_golite062009
  • 11-beta-hydroxysteroid dehydrogenase activity
    		•  0.617411823427239 bayes_pls_golite062009
  • 3-oxoacyl-[acyl-carrier-protein] reductase activity
    		•  0.604742541607263 bayes_pls_golite062009
  • inorganic cation transmembrane transporter activity
    		•  0.547974096538728 bayes_pls_golite062009
  • testosterone 17-beta-dehydrogenase activity
    		•  0.532187027260366 bayes_pls_golite062009
  • hydrogen ion transmembrane transporter activity
    		•  0.407958284055066 bayes_pls_golite062009
  • cation transmembrane transporter activity
    		•  0.400545977964689 bayes_pls_golite062009
  • alcohol dehydrogenase activity, zinc-dependent
    		•  0.311551606659739 bayes_pls_golite062009
  • DNA binding
    		•  0.302492036575815 bayes_pls_golite062009
  • 3-hydroxyacyl-CoA dehydrogenase activity
    		•  0.233238483713519 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.177044638410302 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.100470710829263 bayes_pls_golite062009
  • coenzyme binding
    		•  0.0812901552017963 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle