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View Structure Prediction Details

Protein: dhs-3
Organism: Caenorhabditis elegans
Length: 307 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for dhs-3.

Description E-value Query
Range		 Subject
Range
FABG_THEMA - 3-oxoacyl-[acyl-carrier-protein] reductase FabG OS=Thermotoga maritima GN=fabG PE=3 SV=1
FABG_THEMA - 3-oxoacyl-[acyl-carrier-protein] reductase FabG OS=Thermotoga maritima (strain ATCC 43589 / MSB8 / D...
 269.0 [0..36] [283..2]

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Predicted Domain #1
Region A:
Residues: [1-307] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MQDILESVVV TLHAICLLII STIRNCFPMG WLLRKDVRGQ TVLITGSGSG LGRLMAFEFG  60
   61 KLGARLVLWD INEQGNKETL KELEAMGVEA KAYTVDLSEY KEINRTADLV KSEVGKVDIL 120
  121 VNNAGIVTGK KLLQCPDELM VKTVSVNTNA LFFTTKNFLP GMLESNKGHI VTIASMAGKC 180
  181 GVAGLVDYCA SKHGAVGFND SLASELYALK KDVKTTVVCP IYINTGMFDG IATKWPTLLP 240
  241 ILSPEYVVDC IMEAVLTDRA FLAIPKFSYI FIALAGLLPT EVLNLYGDHF GITHSMDHFK 300
  301 GRQSRQA

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 44.69897
Match: 1yb1A
Description: Crystal structure of human 17-beta-hydroxysteroid dehydrogenase type XI
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
retinol dehydrogenase activity 4.1750549780559 bayes_pls_golite062009
oxidoreductase activity 3.09625241707629 bayes_pls_golite062009
oxidoreductase activity, acting on NADH or NADPH, quinone or similar compound as acceptor 2.344389379767 bayes_pls_golite062009
alcohol dehydrogenase (NAD) activity 2.13179384627038 bayes_pls_golite062009
ethanol binding 2.01597876952325 bayes_pls_golite062009
retinol binding 1.92497267707609 bayes_pls_golite062009
catalytic activity 1.79741889688267 bayes_pls_golite062009
steroid dehydrogenase activity 1.75109362865449 bayes_pls_golite062009
oxidoreductase activity, acting on CH-OH group of donors 1.65338499044318 bayes_pls_golite062009
steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 1.55012034958204 bayes_pls_golite062009
alcohol binding 1.51091775360793 bayes_pls_golite062009
oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 1.47309297191111 bayes_pls_golite062009
3-alpha(17-beta)-hydroxysteroid dehydrogenase (NAD+) activity 1.42175262136734 bayes_pls_golite062009
fatty acid synthase activity 1.23679054027553 bayes_pls_golite062009
benzaldehyde dehydrogenase activity 1.05577641583555 bayes_pls_golite062009
monovalent inorganic cation transmembrane transporter activity 1.05064033662208 bayes_pls_golite062009
receptor activity 1.02559644924534 bayes_pls_golite062009
oxidoreductase activity, acting on NADH or NADPH 1.01627645289834 bayes_pls_golite062009
binding 0.982999356179965 bayes_pls_golite062009
transmembrane receptor activity 0.973650203491298 bayes_pls_golite062009
all-trans retinal binding 0.968189751942231 bayes_pls_golite062009
NADPH:quinone reductase activity 0.955727553358398 bayes_pls_golite062009
signal transducer activity 0.832324207538104 bayes_pls_golite062009
molecular transducer activity 0.832324207538104 bayes_pls_golite062009
oxidoreductase activity, acting on the CH-CH group of donors 0.62461633437589 bayes_pls_golite062009
11-beta-hydroxysteroid dehydrogenase activity 0.617411823427239 bayes_pls_golite062009
3-oxoacyl-[acyl-carrier-protein] reductase activity 0.604742541607263 bayes_pls_golite062009
inorganic cation transmembrane transporter activity 0.547974096538728 bayes_pls_golite062009
testosterone 17-beta-dehydrogenase activity 0.532187027260366 bayes_pls_golite062009
hydrogen ion transmembrane transporter activity 0.407958284055066 bayes_pls_golite062009
cation transmembrane transporter activity 0.400545977964689 bayes_pls_golite062009
alcohol dehydrogenase activity, zinc-dependent 0.311551606659739 bayes_pls_golite062009
DNA binding 0.302492036575815 bayes_pls_golite062009
3-hydroxyacyl-CoA dehydrogenase activity 0.233238483713519 bayes_pls_golite062009
transcription regulator activity 0.177044638410302 bayes_pls_golite062009
nucleic acid binding 0.100470710829263 bayes_pls_golite062009
coenzyme binding 0.0812901552017963 bayes_pls_golite062009
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle