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Protein Overview: EP300_MOUSE

General Information:
Name(s) found: EP300_MOUSE [Swiss-Prot]
Description(s) found:
Found 9 descriptions.
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  • Histone acetyltransferase p300 OS=Mus musculus GN=Ep300 PE=1 SV=2 [Swiss-Prot]
    • Organism: Mus musculus
    Length: 2412 amino acids

    Gene Ontology:
    Cellular Component: nucleus [UNKNOWN][ISS]
    transcription factor complex [IDA]
    cytoplasm [UNKNOWN]
    protein-DNA complex [UNKNOWN]
    histone acetyltransferase complex [IDA]
    Biological Process: histone H4 acetylation [ISS]
    positive regulation of protein import into nucleus, translocation [UNKNOWN]
    positive regulation of translation [UNKNOWN]
    positive regulation of glycoprotein biosynthetic process [UNKNOWN]
    positive regulation of proteolysis [UNKNOWN]
    positive regulation of DNA binding [UNKNOWN]
    positive regulation of transcription factor activity [ISS]
    regulation of transcription [IDA][ISS]
    positive regulation of transcription from RNA polymerase II promoter [UNKNOWN][IGI]
    heart development [IMP]
    response to glucose stimulus [UNKNOWN]
    positive regulation of cell growth [UNKNOWN]
    protein kinase B signaling cascade [UNKNOWN]
    response to hypoxia [ISS]
    positive regulation of collagen biosynthetic process [UNKNOWN]
    positive regulation of cell size [UNKNOWN]
    positive regulation of transcription, DNA-dependent [IDA]
    N-terminal peptidyl-lysine acetylation [ISS]
    apoptosis [ISS]
    response to glucocorticoid stimulus [UNKNOWN]
    positive regulation of protein secretion [UNKNOWN]
    lung development [IMP]
    regulation of angiotensin metabolic process [UNKNOWN]
    positive regulation of sarcomere organization [UNKNOWN]
    protein-DNA complex assembly [UNKNOWN]
    regulation of transcription, DNA-dependent [IDA]
    positive regulation of axon extension [UNKNOWN]
    organ morphogenesis [IMP]
    somitogenesis [IGI]
    response to drug [UNKNOWN]
    skeletal muscle tissue development [IMP]
    positive regulation of gene expression [UNKNOWN]
    response to calcium ion [UNKNOWN]
    positive regulation of protein amino acid phosphorylation [UNKNOWN]
    positive regulation of cellular metabolic process [UNKNOWN]
    negative regulation of cellular metabolic process [UNKNOWN]
    Molecular Function: protein kinase binding [UNKNOWN]
    acetyltransferase activity [ISS]
    transcription factor binding [UNKNOWN]
    peroxisome proliferator activated receptor binding [UNKNOWN]
    bHLH transcription factor binding [UNKNOWN]
    NF-kappaB binding [UNKNOWN]
    histone acetyltransferase activity [UNKNOWN][ISS]
    lysine N-acetyltransferase activity [UNKNOWN]
    DNA binding [IDA][ISS]
    transcription factor activity [UNKNOWN]
    protein binding [IPI]
    SMAD binding [UNKNOWN]
    transcription coactivator activity [ISS]
    antigen binding [UNKNOWN]
    transcription activator activity [UNKNOWN][IDA]
    promoter binding [UNKNOWN]
    mitogen-activated protein kinase binding [UNKNOWN]
    protein complex binding [UNKNOWN]
    glucocorticoid receptor binding [UNKNOWN]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAENVVEPGP PSAKRPKLSS PALSASASDG TDFGSLFDLE HDLPDELINS TELGLTNGGD  60
   61 ISQLQTSLGI VQDAASKHKQ LSELLRSGSS PNLNMGVGGP GQAMASQAQQ NSPGLSLINS 120
  121 MVKSPMAQTG LTSPNMGIGS SGPNQGPTQS PAGMMNSPVN QPAMGMNTGM NAGMNPGMLA 180
  181 AGNGQGIMPN QVMNGSIGAG RGRPNMQYPN AGMGNAGSLL TEPLQQGSPQ MGGQPGLRGP 240
  241 QPLKMGMMNN PSPYGSPYTQ NSGQQIGASG LGLQIQTKTV LPNNLSPFAM DKKAVPGGGM 300
  301 PSMGQQPTPS VQQPGLVTPV AAGMGSGAHT ADPEKRKLIQ QQLVLLLHAH KCQRREQANG 360
  361 EVRQCNLPHC RTMKNVLNHM THCQSGKSCQ VAHCASSRQI ISHWKNCTRH DCPVCLPLKN 420
  421 AGDKRNQQSI LTGAPVGLGN PSSLGVGQQS TPSLSTVSQI DPSSIERAYA ALGLPYQVNQ 480
  481 IPPQPQVQAK NQQSQPSGQS PQGMRSVNNM SASPMGVNGG VGVQTPNLLS DSMLHSTINS 540
  541 QNPMMSENAG VASLGPLPTA AQPSSTGIRK QWHEDITQDL RNHLVHKLVQ AIFPTPDPAA 600
  601 LKDRRMENLV AYARKVEGDM YESANNRAEY YHLLAEKIYK IQKELEEKRR TRLQKQNMLP 660
  661 NAPGMGPVPM NTGSNMGQQP TGMTTNGPVP DPSMIRGSVP NHMMPRMTPQ PGLNQFGQMN 720
  721 MPQPPIGPRQ PSPLQHHGQL AQSGSLNPPM GYGPRMQQAS GQNQFLSQTQ FTSQGMNVTN 780
  781 MPLAPSSGQA PVSQAQMSSS SCPVNSPIMP PGSQGSHIHC PTLPQQAHQN SPSPVPSRTP 840
  841 TPHHTPPSIG NQPPPATAIP TPVPTPPAIP PGPQPPSLHP SSRQTPTPPT HLPPQVQPSL 900
  901 PAAPSADQSQ QQPRSQQSTA VSVPTPTAPL LPPQPSTPLS QPAVSIEGQV SNPPSTSSTE 960
  961 VNSQTIPEKQ PSQEVKMESK MEVDKPEPAD AQPEDTKEAK GEDVKVEPTE MEERGPELKT1020
 1021 DGKEEEEQPS TSATQSSPAP GQSKKKIFKP EELRQALMPT LEALYRQDPE SLPFRQPVDP1080
 1081 QLLGIPDYFD IVKSPMDLST IKRKLDTGQY QEPWQYIDDI WLMFNNAWLY NRKTSRVYKY1140
 1141 CSKLSEVFEQ EIDPVMQSLG YCCGRKLEFS PQTLCCYGKQ LCTIPRDATY YSYQNRYHFC1200
 1201 EKCFNEIQGE SVSLGDDPSQ PQTTINKEQF SKRKNDTLDP ELFVECTECG RKMHQICVLH1260
 1261 HEIIWPSGFV CDGCLKKTAR TRKENKLSAK RLPSTRLGTF LENRVNDFLR RQNHPESGEV1320
 1321 TVRVVHASDK TVEVKPGMKA RFVDSGEMAE SFPYRTKALF AFEEIDGVDL CFFGMHVQEY1380
 1381 GSDCPPPNQR RVYISYLDSV HFFRPKCLRT AVYHEILIGY LEYVKKLGYT TGHIWACPPS1440
 1441 EGDDYIFHCH PPDQKIPKPK RLQEWYKKML DKAVSERIVH DYKDILKQAT EDRLTSAKEL1500
 1501 PYFEGDFWPN VLEESIKELE QEEEERKREE NTSNESTDVT KGDSKNAKKK NNKKTSKNKS1560
 1561 SLSRGNKKKP GMPNVSNDLS QKLYATMEKH KEVFFVIRLI ACPAPNSLPP IVDPDPLIPC1620
 1621 DLMDGRDAFL TLARDKHLEF SSLRRAQWST MCMLVELHTQ SQDRFVYTCN ECKHHVETRW1680
 1681 HCTVCEDYDL CITCYNTKNH DHKMEKLGLG LDDESNNQQA AATQSPGDSR RLSIQRCIQS1740
 1741 LVHACQCRNA NCSLPSCQKM KRVVQHTKGC KRKTNGGCPI CKQLIALCCY HAKHCQENKC1800
 1801 PVPFCLNIKQ KLRQQQLQHR LQQAQMLRRR MASMQRTGVA GQQQGLPSPT PATPTTPTGQ1860
 1861 QPATPQTPQP QPTSQPQPTP PNNMTPYLPR TQTTGPVSQG KAPGQVTPPT PPQTAQAPLP1920
 1921 GPPPAAVEMA MQIQRAAETQ RQMAHVQIFQ RPIQHQMPQM SPMAPMGMNP PPMARGPGGH1980
 1981 LDPGIGPAGM QQQPPWAQGG MPQPQQMQSG MPRPAMMSVA QHGQPLNMAP QPGLGQVGVS2040
 2041 PLKPGTVSQQ ALQNLLRTLR SPSSPLQQQQ VLSILHANPQ LLAAFIKQRA AKYANPNPQP2100
 2101 LPGQPGMTQG QPGLQPPTMP GQQGVHSNPA LQNMNPLQAG VQRAGLPQQQ PQQQLQPPMG2160
 2161 AMSPQAQQMN MNHNTMPSQF RDILRRQMMQ QQGAGPGIGP GMANQFQQPQ GIGYPPQQQQ2220
 2221 QQRMQHHMQQ MQQGNMGQMG QLPQALGAEA GASLQAYQQR LLQQQMGSPA QPNPMSPQQH2280
 2281 MLPNQAQSPH LQGQQIPNSL SNQVRSPQPV PSPRPQSQPP HSSPSPRMQP QPSPHHVSPQ2340
 2341 TSSPHPGLVA AQAANPMEQG HFASPDQNSM LSQLASNPGM ANLHGASATD LGLSSDNADL2400
 2401 NSNLSQSTLD IH

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data



    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.95

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle