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Protein Overview: gi|46560168

General Information:
Name(s) found: gi|46560168 [NCBI NR]
Description(s) found:
Found 2 descriptions.
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  • gi|46560168|gb|AAT00542.1| retinal insulin receptor [Rattus norvegicus] [NCBI NR]
    • Organism: Rattus norvegicus
    Length: 403 amino acids

    Gene Ontology:
    Cellular Component: microsome [UNKNOWN][IDA]
    synapse [IDA]
    plasma membrane [UNKNOWN][IDA]
    insulin receptor complex [UNKNOWN][IEA]
    nucleus [IDA]
    integral to plasma membrane [UNKNOWN]
    caveola [UNKNOWN][IEA]
    soluble fraction [IDA]
    endosome [IDA]
    membrane [UNKNOWN][IEA]
    integral to membrane [IEA]
    cytosol [IDA]
    endosome membrane [UNKNOWN]
    Biological Process: peptidyl-tyrosine phosphorylation [UNKNOWN][IMP]
    protein amino acid autophosphorylation [UNKNOWN][IDA][IEA][IMP]
    fat cell differentiation [IEP]
    positive regulation of mitosis [UNKNOWN][IEA]
    positive regulation of glycogen biosynthetic process [UNKNOWN][IEA]
    positive regulation of developmental growth [UNKNOWN][IEA]
    protein heterotetramerization [UNKNOWN][IDA]
    activation of MAPK activity [UNKNOWN][IEA]
    heart morphogenesis [UNKNOWN][IEA]
    response to glucose stimulus [IEP]
    transformation of host cell by virus [UNKNOWN][IEA]
    response to testosterone stimulus [IEP]
    G-protein coupled receptor protein signaling pathway [UNKNOWN][IEA]
    response to hormone stimulus [IEP]
    response to peptide hormone stimulus [IEA]
    organ morphogenesis [UNKNOWN]
    negative regulation of gene expression [IMP]
    glucose homeostasis [UNKNOWN][IDA]
    response to estradiol stimulus [IEP]
    response to activity [IEP]
    response to nutrient levels [IEP]
    positive regulation of protein kinase B signaling cascade [UNKNOWN][IEA]
    positive regulation of cell migration [UNKNOWN][IEA]
    response to tumor necrosis factor [IMP]
    response to manganese ion [IEP]
    positive regulation of nitric oxide biosynthetic process [UNKNOWN][IEA]
    positive regulation of glycoprotein biosynthetic process [IMP]
    response to vitamin D [IEP]
    positive regulation of respiratory burst [UNKNOWN][IEA]
    insulin receptor signaling pathway [UNKNOWN][IDA][IMP]
    positive regulation of cell proliferation [UNKNOWN][IEA]
    positive regulation of DNA replication [UNKNOWN][IEA]
    protein amino acid phosphorylation [IDA]
    positive regulation of glycolysis [UNKNOWN][IEA]
    cellular response to insulin stimulus [UNKNOWN]
    response to ethanol [IEP]
    response to insulin stimulus [IEP]
    response to glucocorticoid stimulus [IEP]
    activation of protein kinase activity [UNKNOWN]
    regulation of hydrogen peroxide metabolic process [IDA]
    exocrine pancreas development [UNKNOWN][IEA]
    response to protein stimulus [IEP]
    activation of protein kinase B activity [UNKNOWN][IEA]
    positive regulation of phosphorylation [IDA]
    regulation of gene-specific transcription [UNKNOWN][IEA]
    regulation of embryonic development [UNKNOWN][IEA]
    transmembrane receptor protein tyrosine kinase signaling pathway [IEA]
    positive regulation of glucose import [UNKNOWN]
    positive regulation of MAPKKK cascade [UNKNOWN][IEA]
    male sex determination [UNKNOWN][IEA]
    negative regulation of protein amino acid phosphorylation [IMP]
    positive regulation of protein amino acid phosphorylation [UNKNOWN][IEA]
    negative regulation of transporter activity [IMP]
    Molecular Function: phosphoinositide 3-kinase binding [UNKNOWN][IEA]
    3-phosphoinositide-dependent protein kinase binding [IDA]
    insulin-like growth factor receptor binding [UNKNOWN][IEA]
    nucleotide binding [IEA]
    GTP binding [UNKNOWN][IEA]
    ATP binding [UNKNOWN][IEA]
    protein tyrosine kinase activity [UNKNOWN][IDA]
    insulin receptor activity [UNKNOWN][IDA][IMP]
    transmembrane receptor protein tyrosine kinase activity [IEA]
    receptor signaling protein tyrosine kinase activity [UNKNOWN][IEA]
    protein complex binding [IDA]
    insulin-like growth factor I binding [UNKNOWN][IEA]
    insulin-like growth factor II binding [UNKNOWN][IEA]
    PTB domain binding [UNKNOWN][IEA]
    protein kinase binding [IPI]
    insulin binding [UNKNOWN][IDA][IMP]
    protein domain specific binding [IPI]
    protein phosphatase binding [IMP]
    protein kinase activity [IDA]
    receptor activity [IEA]
    SH2 domain binding [UNKNOWN][IEA]
    protein binding [UNKNOWN][IEA][IPI]
    lipoic acid binding [IPI]
    metal ion binding [IEA]
    insulin receptor substrate binding [UNKNOWN][IMP]
    transferase activity [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RKRQPDGPMG PLYASSNPEY LSASDVFPSS VYVPDEWEVP REKITLLREL GQGSFGMVYE  60
   61 GNAKDIIKGE VETRVAVKTV NESASLRERI EFLNEASVMK GFTCHHVVRL LGVVSKGQPT 120
  121 LVVMELMAHG DLKSHLRSLR PDAENNPGRP PPTLQEMIQM TAEIADGMAY LNAKKFVHRD 180
  181 LAARNCMVAH DFTVKIGDFG MTRDIYETDY YRKGGKGLLP VRWMSPEALK DGVFTASSDM 240
  241 WSFGVVLWEI TSLAEQPYQG LSNEQVLKFV MDGGYLDPPD NCPERLTDLM RMCWQFNPKM 300
  301 RPTFLEIVNL LKDDLHPSFP EVSFFYSEEN KAPESEELEM EFEDMENVPL DRSSHCQREE 360
  361 AGCREGGSSL SIKRTYDEHI PYTHMNGGKK NGRVLTSPRS NPS

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data



    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle