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View Structure Prediction Details

Protein: KAO2_ARATH
Organism: Arabidopsis thaliana
Length: 489 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for KAO2_ARATH.

Description E-value Query
Range
Subject
Range
gi|115496944, gi... - gi|94574282|gb|AAI16042.1| Cytochrome P450, family 2, subfamily C, polypeptide 18 [Bos taurus], gi|1...
352.0 [0..35] [486..20]

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Predicted Domain #1
Region A:
Residues: [1-489]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTETGLILMW FPLIILGLFV LKWVLKRVNV WIYVSKLGEK KHYLPPGDLG WPVIGNMWSF  60
   61 LRAFKTSDPE SFIQSYITRY GRTGIYKAHM FGYPCVLVTT PETCRRVLTD DDAFHIGWPK 120
  121 STMKLIGRKS FVGISFEEHK RLRRLTSAPV NGPEALSVYI QFIEETVNTD LEKWSKMGEI 180
  181 EFLSHLRKLT FKVIMYIFLS SESEHVMDSL EREYTNLNYG VRAMGINLPG FAYHRALKAR 240
  241 KKLVAAFQSI VTNRRNQRKQ NISSNRKDML DNLIDVKDEN GRVLDDEEII DLLLMYLNAG 300
  301 HESSGHLTMW ATILMQEHPM ILQKAKEEQE RIVKKRAPGQ KLTLKETREM VYLSQVIDET 360
  361 LRVITFSLTA FREAKSDVQM DGYIIPKGWK VLTWFRNVHL DPEIYPDPKK FDPSRWEGYT 420
  421 PKAGTFLPFG LGSHLCPGND LAKLEISIFL HHFLLKYRVE RSNPGCPVMF LPHNRPKDNC 480
  481 LARITRTMP

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 93.39794
Match: 1pq2A
Description: Crystal Structure of Human Drug Metabolizing Cytochrome P450 2C8
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
arachidonic acid monooxygenase activity 6.76823710927794 bayes_pls_golite062009
monooxygenase activity 5.57229509004705 bayes_pls_golite062009
steroid hydroxylase activity 5.04794778387361 bayes_pls_golite062009
arachidonic acid epoxygenase activity 4.80764258881036 bayes_pls_golite062009
retinoic acid 4-hydroxylase activity 3.76307535769621 bayes_pls_golite062009
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen 3.68151610133025 bayes_pls_golite062009
retinoic acid binding 3.04897926497756 bayes_pls_golite062009
retinoid binding 2.60220937953757 bayes_pls_golite062009
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen 2.56821164444595 bayes_pls_golite062009
isoprenoid binding 2.47826119804163 bayes_pls_golite062009
oxidoreductase activity 2.35847923992364 bayes_pls_golite062009
demethylase activity 2.17116413461366 bayes_pls_golite062009
vitamin D 24-hydroxylase activity 1.81919676974797 bayes_pls_golite062009
oxysterol 7-alpha-hydroxylase activity 1.71732865382274 bayes_pls_golite062009
flavonoid 3'-monooxygenase activity 1.71233606135238 bayes_pls_golite062009
sterol 14-demethylase activity 1.68985995159863 bayes_pls_golite062009
oxygen binding 1.66120675703571 bayes_pls_golite062009
vitamin D3 25-hydroxylase activity 1.65825585934141 bayes_pls_golite062009
vitamin D 25-hydroxylase activity 1.65825585934141 bayes_pls_golite062009
fatty acid (omega-1)-hydroxylase activity 1.65569090470706 bayes_pls_golite062009
electron carrier activity 1.48516712188486 bayes_pls_golite062009
testosterone 6-beta-hydroxylase activity 1.4661447981611 bayes_pls_golite062009
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen 1.46109575978397 bayes_pls_golite062009
binding 1.2866152532988 bayes_pls_golite062009
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen 1.20113920678403 bayes_pls_golite062009
25-hydroxycholecalciferol-24-hydroxylase activity 1.06487564122685 bayes_pls_golite062009
steroid 17-alpha-monooxygenase activity 0.918503562996019 bayes_pls_golite062009
ecdysteroid 25-hydroxylase activity 0.89030345144459 bayes_pls_golite062009
1-alpha,25-dihydroxyvitamin D3 24-hydroxylase activity 0.658520486133281 bayes_pls_golite062009
catalytic activity 0.608111453189583 bayes_pls_golite062009
cholesterol monooxygenase (side-chain-cleaving) activity 0.276594551871869 bayes_pls_golite062009
arachidonic acid 11,12-epoxygenase activity 0.0888154993183798 bayes_pls_golite062009

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