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View Structure Prediction Details

Protein: C71BE_ARATH
Organism: Arabidopsis thaliana
Length: 496 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for C71BE_ARATH.

Description E-value Query
Range
Subject
Range
C71BB_ARATH - Cytochrome P450 71B11 OS=Arabidopsis thaliana GN=CYP71B11 PE=2 SV=1
435.0 [0..1] [496..1]

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Predicted Domain #1
Region A:
Residues: [1-496]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MIWWFIVGAS FFFAFILIAK DTRTTKKNLP PGPPRLPIIG NLHQLGSKPQ RSLFKLSEKY  60
   61 GSLMSLKFGN VSAVVASTPE TVKDVLKTFD AECCSRPYMT YPARVTYNFN DLAFSPYSKY 120
  121 WREVRKMTVI ELYTAKRVKS FQNVRQEEVA SFVDFIKQHA SLEKTVNMKQ KLVKLSGSVI 180
  181 CKVGFGISLE WSKLANTYEE VIQGTMEVVG RFAAADYFPI IGRIIDRITG LHSKCEKVFK 240
  241 EMDSFFDQSI KHHLEDTNIK DDIIGLLLKM EKGETGLGEF QLTRNHTKGI LLNVLIAGVD 300
  301 TSGHTVTWVM THLIKNPRVM KKAQAEVREV IKNKDDITEE DIERLEYLKM VIKETLRINP 360
  361 LVPLLIPREA SKYIKIGGYD IPKKTWIYVN IWAVQRNPNV WKDPEVFIPE RFMHSEIDYK 420
  421 GVDFELLPFG SGRRMCPGMG LGMALVHLTL INLLYRFDWK LPEGMNIEDV DLEESYGLVC 480
  481 PKKVPLQLIP VLTQWT

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 112.0
Match: 1pq2A
Description: Crystal Structure of Human Drug Metabolizing Cytochrome P450 2C8
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
arachidonic acid monooxygenase activity 6.76823710927794 bayes_pls_golite062009
fatty acid (omega-1)-hydroxylase activity 6.3313834755701 bayes_pls_golite062009
monooxygenase activity 5.57229509004705 bayes_pls_golite062009
steroid hydroxylase activity 5.04794778387361 bayes_pls_golite062009
arachidonic acid epoxygenase activity 4.80764258881036 bayes_pls_golite062009
electron carrier activity 4.64931978461551 bayes_pls_golite062009
retinoic acid 4-hydroxylase activity 3.76307535769621 bayes_pls_golite062009
oxygen binding 3.7203678182299 bayes_pls_golite062009
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen 3.68151610133025 bayes_pls_golite062009
flavonoid 3'-monooxygenase activity 3.16634614522939 bayes_pls_golite062009
demethylase activity 2.80780658333504 bayes_pls_golite062009
retinoic acid binding 2.70323898361882 bayes_pls_golite062009
retinoid binding 2.60220937953757 bayes_pls_golite062009
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen 2.56821164444595 bayes_pls_golite062009
isoprenoid binding 2.47826119804163 bayes_pls_golite062009
thromboxane-A synthase activity 2.45281910634006 bayes_pls_golite062009
oxysterol 7-alpha-hydroxylase activity 2.36480328243514 bayes_pls_golite062009
oxidoreductase activity 2.35847923992364 bayes_pls_golite062009
sterol 14-demethylase activity 2.33937429425924 bayes_pls_golite062009
1-alpha,25-dihydroxyvitamin D3 24-hydroxylase activity 2.30416050662077 bayes_pls_golite062009
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen 2.15105968497418 bayes_pls_golite062009
arachidonic acid 11,12-epoxygenase activity 2.0071742914584 bayes_pls_golite062009
vitamin D 24-hydroxylase activity 1.81919676974797 bayes_pls_golite062009
vitamin D3 25-hydroxylase activity 1.65825585934141 bayes_pls_golite062009
vitamin D 25-hydroxylase activity 1.65825585934141 bayes_pls_golite062009
testosterone 6-beta-hydroxylase activity 1.4661447981611 bayes_pls_golite062009
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen 1.46109575978397 bayes_pls_golite062009
binding 1.2866152532988 bayes_pls_golite062009
25-hydroxycholecalciferol-24-hydroxylase activity 1.06487564122685 bayes_pls_golite062009
steroid 17-alpha-monooxygenase activity 0.918503562996019 bayes_pls_golite062009
ecdysteroid 25-hydroxylase activity 0.89030345144459 bayes_pls_golite062009
protein binding 0.836411857417911 bayes_pls_golite062009
catalytic activity 0.608111453189583 bayes_pls_golite062009
iron ion binding 0.529598228513719 bayes_pls_golite062009
cation binding 0.510556740388808 bayes_pls_golite062009
metal ion binding 0.510556740388808 bayes_pls_golite062009
ion binding 0.503326724714616 bayes_pls_golite062009
transition metal ion binding 0.450436868179747 bayes_pls_golite062009
cholesterol monooxygenase (side-chain-cleaving) activity 0.276594551871869 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle