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View Structure Prediction Details

Protein: cyp-29A2
Organism: Caenorhabditis elegans
Length: 503 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for cyp-29A2.

Description E-value Query
Range		 Subject
Range
gi|76654204 - gi|76654204|ref|XP_584699.2| PREDICTED: similar to cytochrome P450, subfamily IIIA, polypeptide 4 is...
 383.0 [0..1] [503..1]

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Predicted Domain #1
Region A:
Residues: [1-503] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTIFIPISIA IILAYLATWI PTLLKYKRHW QYGSKLPGPP AHPIFGNLGP IVGKKTEDLP  60
   61 SVFINWAAEQ RDQGHSVMRV MILGKVYAWP LNGKAAAAII DSTTETNKGD DYRFFDPWLG 120
  121 GGLLLEGYGE RWKSHRKMLT PAFHFAKLGG YFEVFNNESK ILIDLLSDFS ASGETVDIFP 180
  181 YVKRCALDII SETAMGIKID AQINHDHKYV QAVEGYNKIG VLVSFNPHLK NQFIFWATGY 240
  241 KAQYDDYLST LKSMTEKVIK ERRAAHDSGE VEKETSKRMM NFLDLMLSME ESNQLTSEDI 300
  301 RQEVDTFMFA GHDTTTSSTS WACWNLAHNP NVQEKVYKEM IEVFGDDPNT DITLENVNNL 360
  361 NYLDIVLKES KRIIAPVPAL QRKLTNDLEI DGYIVPAGGN VTISPMVLHS NHHVFKNPTE 420
  421 FNPDRFLPDE VSKRHPYDFM PFLAGPRNCI GQKFAQLNEK VMISHIVRNF KIEPTLKYND 480
  481 TKPCLEVVTK PSNGIPVRLI RRN

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 100.0
Match: 1tqnA
Description: Crystal Structure of Human Microsomal P450 3A4
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
arachidonic acid monooxygenase activity 6.76823710927794 bayes_pls_golite062009
fatty acid (omega-1)-hydroxylase activity 6.3313834755701 bayes_pls_golite062009
monooxygenase activity 5.57229509004705 bayes_pls_golite062009
steroid hydroxylase activity 5.04794778387361 bayes_pls_golite062009
arachidonic acid epoxygenase activity 4.80764258881036 bayes_pls_golite062009
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen 3.68151610133025 bayes_pls_golite062009
demethylase activity 3.40807632433846 bayes_pls_golite062009
fluorene oxygenase activity 3.16634614522939 bayes_pls_golite062009
sterol 14-demethylase activity 2.94610675710811 bayes_pls_golite062009
oxygen binding 2.77495508953933 bayes_pls_golite062009
retinoic acid 4-hydroxylase activity 2.60901411823382 bayes_pls_golite062009
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen 2.56821164444595 bayes_pls_golite062009
oxysterol 7-alpha-hydroxylase activity 2.36480328243514 bayes_pls_golite062009
oxidoreductase activity 2.35847923992364 bayes_pls_golite062009
steroid 7-alpha-hydroxylase activity 2.21042366294727 bayes_pls_golite062009
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen 2.15105968497418 bayes_pls_golite062009
arachidonic acid 11,12-epoxygenase activity 2.0071742914584 bayes_pls_golite062009
retinoid binding 1.91237853759594 bayes_pls_golite062009
vitamin D 24-hydroxylase activity 1.81919676974797 bayes_pls_golite062009
isoprenoid binding 1.78853880472253 bayes_pls_golite062009
flavonoid 3'-monooxygenase activity 1.71233606135238 bayes_pls_golite062009
vitamin D3 25-hydroxylase activity 1.65825585934141 bayes_pls_golite062009
vitamin D 25-hydroxylase activity 1.65825585934141 bayes_pls_golite062009
retinoic acid binding 1.55035199545719 bayes_pls_golite062009
electron carrier activity 1.48516712188486 bayes_pls_golite062009
testosterone 6-beta-hydroxylase activity 1.4661447981611 bayes_pls_golite062009
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen 1.46109575978397 bayes_pls_golite062009
binding 1.2866152532988 bayes_pls_golite062009
25-hydroxycholecalciferol-24-hydroxylase activity 1.06487564122685 bayes_pls_golite062009
ecdysteroid 25-hydroxylase activity 0.89030345144459 bayes_pls_golite062009
steroid 17-alpha-monooxygenase activity 0.88385909514903 bayes_pls_golite062009
catalytic activity 0.608111453189583 bayes_pls_golite062009
cholesterol monooxygenase (side-chain-cleaving) activity 0.276594551871869 bayes_pls_golite062009
1-alpha,25-dihydroxyvitamin D3 24-hydroxylase activity 0.203772707673481 bayes_pls_golite062009
YRC Informatics Platform - Version 3.0
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