YRC Public Data Repository - Protein Structure Prediction

Protein:	CE05526
Organism:	Caenorhabditis elegans
Length:	278 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for CE05526.

Description	E-value	Query Range	Subject Range
FABG_THEMA - 3-oxoacyl-[acyl-carrier-protein] reductase FabG OS=Thermotoga maritima GN=fabG PE=3 SV=1 FABG_THEMA - 3-oxoacyl-[acyl-carrier-protein] reductase FabG OS=Thermotoga maritima (strain ATCC 43589 / MSB8 / D...	284.0	[0..3]	[264..2]
gi\|146296617, gi... - gi\|82501013\|ref\|ZP_00886394.1\| 3-oxoacyl-(acyl-carrier-protein) reductase [Caldicellulosiruptor sacc...	279.0	[0..1]	[264..1]
gi\|187033921, gi... - gi\|39592651\|emb\|CAE62265.1\| Hypothetical protein CBG06324 [Caenorhabditis briggsae], gi\|187033921\|em...	277.0	[0..1]	[277..1]
gi\|115250215, gi... - gi\|126698778\|ref\|YP_001087675.1\| 3-oxoacyl-[acyl-carrier protein] reductase [Clostridium difficile 6... gi\|255306086 - gi\|255306086\|ref\|ZP_05350258.1\| 3-oxoacyl-[acyl-carrier protein] reductase [Clostridium difficile AT... gi\|255100197 - gi\|255100197\|ref\|ZP_05329174.1\| 3-oxoacyl-[acyl-carrier protein] reductase [Clostridium difficile QC...	274.0	[0..1]	[264..1]
gi\|255313843 - gi\|255313843\|ref\|ZP_05355426.1\| 3-oxoacyl-[acyl-carrier protein] reductase [Clostridium difficile QC... gi\|255516524 - gi\|255516524\|ref\|ZP_05384200.1\| 3-oxoacyl-[acyl-carrier protein] reductase [Clostridium difficile QC... gi\|255649624 - gi\|255649624\|ref\|ZP_05396526.1\| 3-oxoacyl-[acyl-carrier protein] reductase [Clostridium difficile QC... gi\|254974717 - gi\|254974717\|ref\|ZP_05271189.1\| 3-oxoacyl-[acyl-carrier protein] reductase [Clostridium difficile QC... gi\|255092105 - gi\|255092105\|ref\|ZP_05321583.1\| 3-oxoacyl-[acyl-carrier protein] reductase [Clostridium difficile CI... gi\|90575404, gi\|... - gi\|90575404\|ref\|ZP_01231888.1\| hypothetical protein CdifQ_02001165 [Clostridium difficile QCD-32g58]...	274.0	[0..1]	[264..1]
gi\|18310052, gi\|... - gi\|18310052\|ref\|NP_561986.1\| 3-ketoacyl-(acyl-carrier-protein) reductase [Clostridium perfringens st...	272.0	[0..4]	[264..2]
gi\|89098688, gi\|... - gi\|89098688\|ref\|ZP_01171570.1\| beta-ketoacyl-acyl carrier protein reductase [Bacillus sp. NRRL B-149...	272.0	[0..3]	[264..2]
gi\|53688164 - gi\|53688164\|ref\|ZP_00110036.2\| COG1028: Dehydrogenases with different specificities (related to shor...	270.0	[0..2]	[267..107]
gi\|28210515, gi\|... - gi\|28210515\|ref\|NP_781459.1\| 3-ketoacyl-(acyl-carrier-protein) reductase [Clostridium tetani E88], g...	270.0	[0..4]	[262..6]

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Predicted Domain #1

Region A:
Residues: [1-278]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTRFAEKVAI ITGSSNGIGR ATAVLFAREG AKVTITGRHA ERLEETRQQI LAAGVSEQNV  60
   61 NSVVADVTTD AGQDEILSTT LGKFGKLDIL VNNAGAAIPD SQSKTGTAQS IESYDATLNL 120
  121 NLRSVIALTK KAVPHLSSTK GEIVNISSIA SGLHATPDFP YYSIAKAAID QYTRNTAIDL 180
  181 IQHGIRVNSI SPGLVATGFG SAMGMPEETS KKFYSTMATM KECVPAGVMG QPQDIAEVIA 240
  241 FLADRKTSSY IIGHQLVVDG GSSLIMGLHC QDFAKLLH

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	72.0
Match:	1spxA
Description:	Crystal Structure of Glucose Dehydrogenase of Caenorhabditis Elegans in the Apo-Form
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
retinoid binding	4.36318432223816	bayes_pls_golite062009
isoprenoid binding	4.24457936559037	bayes_pls_golite062009
retinol dehydrogenase activity	4.1750549780559	bayes_pls_golite062009
steroid dehydrogenase activity	3.70115036051018	bayes_pls_golite062009
steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	3.56748749904419	bayes_pls_golite062009
oxidoreductase activity	3.09625241707629	bayes_pls_golite062009
3-hydroxyacyl-CoA dehydrogenase activity	3.06391460989761	bayes_pls_golite062009
oxidoreductase activity, acting on the CH-CH group of donors	3.02758902218302	bayes_pls_golite062009
ethanol binding	3.01624801418439	bayes_pls_golite062009
retinol binding	2.89007863838685	bayes_pls_golite062009
L-iditol 2-dehydrogenase activity	2.85461175493562	bayes_pls_golite062009
11-beta-hydroxysteroid dehydrogenase activity	2.8067651687144	bayes_pls_golite062009
oxidoreductase activity, acting on NADH or NADPH, quinone or similar compound as acceptor	2.66329970371321	bayes_pls_golite062009
structural molecule activity	2.31813292180084	bayes_pls_golite062009
benzaldehyde dehydrogenase activity	2.03039843216597	bayes_pls_golite062009
oxidoreductase activity, acting on NADH or NADPH	1.81060491890041	bayes_pls_golite062009
3-alpha(17-beta)-hydroxysteroid dehydrogenase (NAD+) activity	1.80383455383329	bayes_pls_golite062009
catalytic activity	1.79741889688267	bayes_pls_golite062009
DNA binding	1.76363334651124	bayes_pls_golite062009
transcription regulator activity	1.70071720869899	bayes_pls_golite062009
oxidoreductase activity, acting on CH-OH group of donors	1.65338499044318	bayes_pls_golite062009
nucleic acid binding	1.58440778443922	bayes_pls_golite062009
L-arabinitol 2-dehydrogenase activity	1.54130379492877	bayes_pls_golite062009
alcohol binding	1.51091775360793	bayes_pls_golite062009
all-trans retinal binding	1.47861183836779	bayes_pls_golite062009
oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	1.47309297191111	bayes_pls_golite062009
alcohol dehydrogenase (NAD) activity	1.27032644348698	bayes_pls_golite062009
fatty acid synthase activity	1.23679054027553	bayes_pls_golite062009
NADPH:quinone reductase activity	1.19042587095474	bayes_pls_golite062009
sorbose reductase activity	1.06293597394863	bayes_pls_golite062009
C-3 sterol dehydrogenase (C-4 sterol decarboxylase) activity	1.03845584151228	bayes_pls_golite062009
transcription factor activity	1.00440715995478	bayes_pls_golite062009
binding	0.982999356179965	bayes_pls_golite062009
monovalent inorganic cation transmembrane transporter activity	0.905392379451071	bayes_pls_golite062009
electron carrier activity	0.851536992751213	bayes_pls_golite062009
alcohol dehydrogenase activity, zinc-dependent	0.729242797855749	bayes_pls_golite062009
7-beta-hydroxysteroid dehydrogenase (NADP+) activity	0.695969796208571	bayes_pls_golite062009
retinal dehydrogenase activity	0.69372321031969	bayes_pls_golite062009
3-oxoacyl-[acyl-carrier-protein] reductase activity	0.604742541607263	bayes_pls_golite062009
testosterone 17-beta-dehydrogenase activity	0.532187027260366	bayes_pls_golite062009
NAD or NADH binding	0.44922383360529	bayes_pls_golite062009
enoyl-CoA hydratase activity	0.439912268968251	bayes_pls_golite062009
coenzyme binding	0.35922330382799	bayes_pls_golite062009
inorganic cation transmembrane transporter activity	0.331998750763528	bayes_pls_golite062009
hydrogen ion transmembrane transporter activity	0.261132005311306	bayes_pls_golite062009
cation transmembrane transporter activity	0.200409117794759	bayes_pls_golite062009
methylenetetrahydrofolate dehydrogenase activity	0.124826575912808	bayes_pls_golite062009
methenyltetrahydrofolate cyclohydrolase activity	0.118312276550651	bayes_pls_golite062009
ion transmembrane transporter activity	0.0361234153211201	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: