YRC Public Data Repository - Protein Structure Prediction

Protein:	spo4
Organism:	Schizosaccharomyces pombe
Length:	429 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for spo4.

Description	E-value	Query Range	Subject Range
HOG1_CANGA - Mitogen-activated protein kinase HOG1 OS=Candida glabrata GN=HOG1 PE=3 SV=1 HOG1_CANGA - Mitogen-activated protein kinase HOG1 OS=Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / N...	218.0	[0..29]	[427..12]
gi\|92700087, gi\|... - gi\|92700087\|dbj\|BAB18271.2\| mitogen-activated protein kinase [Chlamydomonas reinhardtii], gi\|1594844...	215.0	[0..30]	[426..48]
gi\|54656676 - gi\|54656676\|gb\|EAL35600.1\| mitogen-activated protein kinase 1, serine/threonine protein kinase [Cryp... gi\|67594677 - gi\|67594677\|ref\|XP_665828.1\| mitogen-activated protein kinase 1, serine/threonine protein kinase [Cr...	214.0	[0..34]	[425..7]
HOG1_ASHGO - Mitogen-activated protein kinase HOG1 OS=Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923... HOG1_ASHGO - Mitogen-activated protein kinase HOG1 OS=Ashbya gossypii GN=HOG1 PE=3 SV=2	214.0	[0..18]	[427..1]
gi\|24430320 - gi\|24430320\|emb\|CAC87145.1\| MAP kinase [Claviceps purpurea]	213.0	[0..30]	[428..13]
gi\|151941278 - gi\|151941278\|gb\|EDN59656.1\| MAP kinase kinase (MEK) [Saccharomyces cerevisiae YJM789] HOG1_YEAST - Mitogen-activated protein kinase HOG1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=HO... HOG1 - Mitogen-activated protein kinase involved in osmoregulation via three independent osmosensors; media... gi\|190406146 - gi\|190406146\|gb\|EDV09413.1\| MAP kinase [Saccharomyces cerevisiae RM11-1a] gi\|207343070 - gi\|207343070\|gb\|EDZ70646.1\| YLR113Wp-like protein [Saccharomyces cerevisiae AWRI1631]	212.0	[0..29]	[427..12]
HOG1_DEBHA - Mitogen-activated protein kinase HOG1 - Debaryomyces hansenii (Yeast) (Torulaspora hansenii) gi\|50423265, gi\|... - gi\|50423265\|ref\|XP_460213.1\| DEHA-HOG1 [Debaryomyces hansenii CBS767], gi\|49655881\|emb\|CAG88486.1\| D...	211.0	[0..29]	[427..12]
gi\|89279387 - gi\|89279387\|gb\|ABD67163.1\| putative MAP kinase [Fusarium proliferatum]	209.0	[0..28]	[428..11]
HOG1_CANAL - Mitogen-activated protein kinase HOG1 OS=Candida albicans GN=HOG1 PE=1 SV=2 HOG1_CANAL - Mitogen-activated protein kinase HOG1 OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=HOG1 PE... gi\|238882126 - gi\|238882126\|gb\|EEQ45764.1\| mitogen-activated protein kinase HOG1 [Candida albicans WO-1]	209.0	[0..29]	[427..12]
HOG1_ASPFU - Mitogen-activated protein kinase hog1 OS=Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 10... HOG1_ASPFU - Mitogen-activated protein kinase hog1 OS=Aspergillus fumigatus GN=hog1 PE=1 SV=1 gi\|159131418 - gi\|159131418\|gb\|EDP56531.1\| MAP kinase SakA [Aspergillus fumigatus A1163]	209.0	[0..29]	[427..9]

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Predicted Domain #1

Region A:
Residues: [1-429]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLSMLLPFGN SGVYASDVDR EDRPEIAKLV QAFPTIEEDY HVVKLVGAGS FSSVFKAVDR  60
   61 HFDSYDNSYW ISSQIEDQMP HDKTKRPKNH FVALKRIYAT VLPSRIQTEL EMLHELRGSD 120
  121 CVLNMITAVR HQDQVLIVLP FIQHAEFRDF YMKYSLPEIG AYLRDLLKGL AHIDAKGIIH 180
  181 RDIKPGNFAW NPYTQRGVIL DFGLAQWQEA DAPTENCCVD KLRKLKQEGK YYDYFPFEKT 240
  241 IADPPEGYLL HDPRPTKRAD RAGTRGFRAP EVLFRCQNQT SSIDVWSVGV ILLCFLTHRY 300
  301 PFFRCEDDID AIVELAHIFG RNGMSNCALL HGQIWSDNIP TLLDQKHNWL DLIASITKND 360
  361 ENLILETSSD YQVALAIDLL DKLLELHPSK RVKAKTALQH EFFNACGVTR SGFEAENPFR 420
  421 SDFPSTVEQ

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	50.0
Match:	1a9uA
Description:	THE COMPLEX STRUCTURE OF THE MAP KINASE P38/SB203580
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
phosphotransferase activity, alcohol group as acceptor	5.49988294224815	bayes_pls_golite062009
protein kinase activity	5.4586557943719	bayes_pls_golite062009
kinase activity	5.3287080791198	bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups	4.96052051118534	bayes_pls_golite062009
protein serine/threonine kinase activity	4.46381887831481	bayes_pls_golite062009
transferase activity	3.97138602499442	bayes_pls_golite062009
binding	2.74863538127007	bayes_pls_golite062009
structural molecule activity	2.32133082120229	bayes_pls_golite062009
ATP binding	1.97600611746091	bayes_pls_golite062009
adenyl ribonucleotide binding	1.93596671856664	bayes_pls_golite062009
adenyl nucleotide binding	1.90928021591891	bayes_pls_golite062009
purine ribonucleotide binding	1.65732943334212	bayes_pls_golite062009
ribonucleotide binding	1.65726906484847	bayes_pls_golite062009
purine nucleotide binding	1.63763394711025	bayes_pls_golite062009
nucleotide binding	1.63195828048121	bayes_pls_golite062009
transcription regulator activity	1.56748951434625	bayes_pls_golite062009
nucleic acid binding	1.46547714006072	bayes_pls_golite062009
protein tyrosine kinase activity	1.3898059094397	bayes_pls_golite062009
receptor signaling protein serine/threonine kinase activity	1.38496328649031	bayes_pls_golite062009
DNA binding	1.35333135345112	bayes_pls_golite062009
receptor signaling protein activity	1.27291233344322	bayes_pls_golite062009
protein binding	1.22565748038754	bayes_pls_golite062009
catalytic activity	1.21655087018101	bayes_pls_golite062009
cytoskeletal protein binding	1.1208666000428	bayes_pls_golite062009
transcription factor activity	1.10928254946881	bayes_pls_golite062009
cyclin-dependent protein kinase activity	0.959360414036299	bayes_pls_golite062009
MAP kinase activity	0.81943579965027	bayes_pls_golite062009
tubulin binding	0.488928950975855	bayes_pls_golite062009
protein serine/threonine/tyrosine kinase activity	0.48345772948903	bayes_pls_golite062009
actin binding	0.464111806616899	bayes_pls_golite062009
magnesium ion binding	0.393328812780268	bayes_pls_golite062009
MAP kinase kinase kinase activity	0.37115026509016	bayes_pls_golite062009
MAP kinase kinase activity	0.35402045013148	bayes_pls_golite062009
signal transducer activity	0.270054246024761	bayes_pls_golite062009
molecular transducer activity	0.270054246024761	bayes_pls_golite062009
structure-specific DNA binding	0.267404531445803	bayes_pls_golite062009
RNA binding	0.245748631571068	bayes_pls_golite062009
microtubule binding	0.196718452862042	bayes_pls_golite062009
ligase activity, forming carbon-oxygen bonds	0.149958560815481	bayes_pls_golite062009
ligase activity, forming aminoacyl-tRNA and related compounds	0.149958560815481	bayes_pls_golite062009
aminoacyl-tRNA ligase activity	0.14842991990838	bayes_pls_golite062009
protein kinase C activity	0.0795689006739899	bayes_pls_golite062009
transmembrane receptor protein kinase activity	0.0556163711947139	bayes_pls_golite062009
transmembrane receptor activity	0.00652065412910241	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: