YRC Public Data Repository - Protein Structure Prediction

Protein:	pck2
Organism:	Schizosaccharomyces pombe
Length:	1016 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for pck2.

Description	E-value	Query Range	Subject Range
gi\|40746128, gi\|... - gi\|67515649\|ref\|XP_657710.1\| KPC1_ASPNG Protein kinase C-like [Aspergillus nidulans FGSC A4], ref\|XP...	893.0	[0..5]	[1006..4]
gi\|38524427 - gi\|38524427\|dbj\|BAD02338.1\| protein kinase C [Emericella nidulans]	891.0	[0..5]	[1006..4]
gi\|145254670 - gi\|145254670\|ref\|XP_001398700.1\| protein kinase C pkcA-Aspergillus niger KPC1_ASPNG - Protein kinase C-like OS=Aspergillus niger GN=pkcA PE=3 SV=1	883.0	[0..5]	[1006..4]
gi\|169779153 - gi\|169779153\|ref\|XP_001824041.1\| hypothetical protein [Aspergillus oryzae RIB40] gi\|83772780 - gi\|83772780\|dbj\|BAE62908.1\| unnamed protein product [Aspergillus oryzae]	882.0	[0..5]	[1006..4]
gi\|303941 - gi\|303941\|dbj\|BAA03268.1\| protein kinase [Schizosaccharomyces pombe]	879.0	[0..1]	[1016..1]
gi\|119174448, gi... - gi\|90298371\|gb\|EAS28002.1\| hypothetical protein CIMG_09206 [Coccidioides immitis RS], gi\|119174448\|r...	863.0	[0..1]	[1006..1]
gi\|70997413, gi\|... - gi\|70997413\|ref\|XP_753454.1\| protein kinase c [Aspergillus fumigatus Af293], gi\|66851090\|gb\|EAL91416... gi\|159126817 - gi\|159126817\|gb\|EDP51933.1\| protein kinase c [Aspergillus fumigatus A1163]	854.0	[0..5]	[1006..4]
gi\|115387501, gi... - gi\|115387501\|ref\|XP_001211256.1\| hypothetical protein ATEG_02078 [Aspergillus terreus NIH2624], gi\|1...	852.0	[0..5]	[1006..4]
gi\|111064604 - gi\|111064604\|gb\|EAT85724.1\| hypothetical protein SNOG_07073 [Phaeosphaeria nodorum SN15]	840.0	[0..1]	[1006..1]
gi\|30172014 - gi\|30172014\|gb\|AAP20604.1\| protein kinase C [Pichia pastoris]	783.0	[0..5]	[1007..7]

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Predicted Domain #1

Region A:
Residues: [1-207]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDMIDEAITE VVRKIERERS VIHGALSMKR LTQNQTVHQQ LHSNIEESKK SIIYLEERLE  60
   61 KLKLRKNGVR KSNSEKPSVG IEKNPSFSTT KSAKSFSSTS SNIDSNLDLL NYDTPLTISK 120
  121 ISFLLQQLEF KLSVEEQYRK GIEKMAKLYE REHDRRSIAE AEKKYVESAQ KITLLKQALK 180
  181 RYHDLHIEID EEDVPSTESR GNLNARR

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	5.30103
Match:	1i84S
Description:	Heavy meromyosin subfragment
Matching Structure (courtesy of the PDB):

Predicted Domain #2

Region A:
Residues: [208-330]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PQSGLLKITV GSLRNVTHSA GISKQTEMIV AIRAEDLERA RTRPSRTDRF NETFEIDLEK  60
   61 TNEVEIVVYE KKNEKLLLPV GLLWIRLSDL VEKQRRKKVE QEVSDKGWVS ADKMINQRLS 120
  121 IFL

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	18.69897
Match:	1gmiA
Description:	Domain from protein kinase C epsilon
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
calcium-dependent phospholipid binding	3.93415448210371	bayes_pls_golite062009
binding	2.77482286467294	bayes_pls_golite062009
phospholipid binding	2.74013385479058	bayes_pls_golite062009
protein binding	2.38962673708753	bayes_pls_golite062009
neurexin binding	1.99616093461872	bayes_pls_golite062009
lipid binding	1.47484095830847	bayes_pls_golite062009
transporter activity	1.2628067945512	bayes_pls_golite062009
signal transducer activity	1.10701462579828	bayes_pls_golite062009
molecular transducer activity	1.10701462579828	bayes_pls_golite062009
substrate-specific transporter activity	0.816751946072324	bayes_pls_golite062009
receptor activity	0.516117489846513	bayes_pls_golite062009
SNARE binding	0.3731056408292	bayes_pls_golite062009
profilin binding	0.32399339703241	bayes_pls_golite062009
syntaxin-1 binding	0.273890767897551	bayes_pls_golite062009
calmodulin binding	0.26906635924237	bayes_pls_golite062009

Predicted Domain #3

Region A:
Residues: [331-506]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PSALNNISKP ESTDRPNTAS GNQSVSAWFS LEPMGQINLT MNFTKHNTRK RPMDAGLGRQ  60
   61 GAIRQRKESV HEVYGHKFLQ HQFYQIMRCA LCGEFLKNAA GMQCIDCHYT CHKKCYPKVV 120
  121 TKCISKSSDS ASSEYEKINH RIPHHFESHT NIGANWCCHC GYILPLGRKT ARKCTE

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	14.522879
Match:	1xa6A
Description:	Crystal Structure of the Human Beta2-Chimaerin
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
general RNA polymerase II transcription factor activity	3.71782887289779	bayes_pls_golite062009
binding	2.79128751898373	bayes_pls_golite062009
transcription regulator activity	2.46263947480513	bayes_pls_golite062009
protein binding	2.34145982999922	bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor	2.10625597744594	bayes_pls_golite062009
kinase activity	2.03632850156074	bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups	1.8531437045627	bayes_pls_golite062009
nucleic acid binding	1.82531145751347	bayes_pls_golite062009
DNA binding	1.72922049905059	bayes_pls_golite062009
protein kinase activity	1.62921423829738	bayes_pls_golite062009
transferase activity	1.4550521488922	bayes_pls_golite062009
GTPase regulator activity	1.39167263636091	bayes_pls_golite062009
nucleoside-triphosphatase regulator activity	1.37139209958305	bayes_pls_golite062009
signal transducer activity	1.25507073225414	bayes_pls_golite062009
molecular transducer activity	1.25507073225414	bayes_pls_golite062009
transcription factor activity	1.11322421505516	bayes_pls_golite062009
protein serine/threonine kinase activity	0.956859696337723	bayes_pls_golite062009
enzyme regulator activity	0.911061212692491	bayes_pls_golite062009
guanyl-nucleotide exchange factor activity	0.907368864863833	bayes_pls_golite062009
RNA polymerase II transcription factor activity	0.82595403841582	bayes_pls_golite062009
small GTPase regulator activity	0.661240850692236	bayes_pls_golite062009
kinase binding	0.494958567742569	bayes_pls_golite062009
catalytic activity	0.194464246602439	bayes_pls_golite062009

Predicted Domain #4

Region A:
Residues: [507-956]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 CGITAHAQCV HLVPDFCGMS MEMANRVISE IRTTKIYKAQ QHKQKSSHHK HHHHKKSKSS  60
   61 SSKHKENDKA SVSITTTTTP SITPADPVPT SPKPLAIEPV KRKPVHAGNL EVTSVSDNKL 120
  121 GATVQVVEQK VDDKADALTK PPSLDAVKEP IPVPSVETSV VAQDLTHKAK RIGLEDFTFL 180
  181 SVLGKGNFGK VMLAELKSEK QLYAIKVLKK EFILENDEVE STKSEKRVFL VANRERHPFL 240
  241 VNLHSCFQTE TRIYFVMDFV SGGDLMLHIQ QEQFSRRRAQ FYAAEVCLAL KYFHDNGIIY 300
  301 RDLKLDNILL SPDGHVKVAD YGLCKEDMWH DNTTATFCGT PEFMAPEILL EQQYTRSVDW 360
  361 WAFGVLIYQM LLGQSPFRGE DEEEIFDAIL SDEPLYPIHM PRDSVSILQQ LLTRDPKKRL 420
  421 GSGPNDAEDV MTHPFFSNIN WDDIYHKRTQ

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	62.39794
Match:	1opkA
Description:	Abl tyrosine kinase, SH3 domain; Abl tyrosine kinase; Abelsone tyrosine kinase (abl)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
phosphotransferase activity, alcohol group as acceptor	5.49988294224815	bayes_pls_golite062009
protein kinase activity	5.4586557943719	bayes_pls_golite062009
kinase activity	5.3287080791198	bayes_pls_golite062009
cyclic nucleotide-dependent protein kinase activity	4.97855712164511	bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups	4.96052051118534	bayes_pls_golite062009
cAMP-dependent protein kinase activity	4.66277812893755	bayes_pls_golite062009
protein serine/threonine kinase activity	4.46381887831481	bayes_pls_golite062009
transferase activity	3.97138602499442	bayes_pls_golite062009
protein tyrosine kinase activity	2.8153155526437	bayes_pls_golite062009
telethonin binding	2.81155575828766	bayes_pls_golite062009
binding	2.74863538127007	bayes_pls_golite062009
signal transducer activity	2.40586892801446	bayes_pls_golite062009
molecular transducer activity	2.40586892801446	bayes_pls_golite062009
protein binding	2.276111749106	bayes_pls_golite062009
tubulin binding	2.18641675163967	bayes_pls_golite062009
cytoskeletal protein binding	2.12615078788254	bayes_pls_golite062009
receptor signaling protein activity	2.10379226653669	bayes_pls_golite062009
tau-protein kinase activity	2.00481226596005	bayes_pls_golite062009
ATP binding	1.97600611746091	bayes_pls_golite062009
adenyl ribonucleotide binding	1.93596671856664	bayes_pls_golite062009
alpha-actinin binding	1.92962505218614	bayes_pls_golite062009
adenyl nucleotide binding	1.90928021591891	bayes_pls_golite062009
microtubule binding	1.88110801192607	bayes_pls_golite062009
actin binding	1.87817875565699	bayes_pls_golite062009
acetylcholine receptor activator activity	1.83545227594542	bayes_pls_golite062009
phosphoinositide 3-kinase binding	1.82515074380651	bayes_pls_golite062009
receptor signaling protein serine/threonine kinase activity	1.81249386965144	bayes_pls_golite062009
molecular adaptor activity	1.81145713371725	bayes_pls_golite062009
transmembrane receptor protein kinase activity	1.7769021678395	bayes_pls_golite062009
transmembrane receptor activity	1.6878868450299	bayes_pls_golite062009
purine ribonucleotide binding	1.65732943334212	bayes_pls_golite062009
ribonucleotide binding	1.65726906484847	bayes_pls_golite062009
purine nucleotide binding	1.63763394711025	bayes_pls_golite062009
nucleotide binding	1.63195828048121	bayes_pls_golite062009
insulin receptor substrate binding	1.62657794525303	bayes_pls_golite062009
SH3/SH2 adaptor activity	1.59474164216385	bayes_pls_golite062009
receptor activity	1.57112777506542	bayes_pls_golite062009
transmembrane receptor protein tyrosine kinase activity	1.4571078357189	bayes_pls_golite062009
general RNA polymerase II transcription factor activity	1.32254739984688	bayes_pls_golite062009
gamma-tubulin binding	1.28511591054866	bayes_pls_golite062009
kinase binding	1.26086833316556	bayes_pls_golite062009
ErbB-3 class receptor binding	1.25765701903393	bayes_pls_golite062009
catalytic activity	1.21655087018101	bayes_pls_golite062009
transcription regulator activity	1.16307073947901	bayes_pls_golite062009
transporter activity	1.11833481501707	bayes_pls_golite062009
nucleic acid binding	1.07139311422871	bayes_pls_golite062009
protein kinase binding	1.06030596516506	bayes_pls_golite062009
ErbB-2 class receptor binding	1.02996109010965	bayes_pls_golite062009
DNA binding	1.02122968429273	bayes_pls_golite062009
transmembrane transporter activity	0.97575992765505	bayes_pls_golite062009
cyclin-dependent protein kinase activity	0.959360414036299	bayes_pls_golite062009
protein binding, bridging	0.83823250804321	bayes_pls_golite062009
transcription factor activity	0.825932471558326	bayes_pls_golite062009
MAP kinase activity	0.81943579965027	bayes_pls_golite062009
actin filament binding	0.794152600084	bayes_pls_golite062009
fibroblast growth factor receptor activity	0.74959456132261	bayes_pls_golite062009
substrate-specific transporter activity	0.705905455086486	bayes_pls_golite062009
phosphoinositide 3-kinase regulator activity	0.688047400629641	bayes_pls_golite062009
vinculin binding	0.666656406096231	bayes_pls_golite062009
structural constituent of cytoskeleton	0.612883428421652	bayes_pls_golite062009
protein complex binding	0.599713385230491	bayes_pls_golite062009
protein serine/threonine/tyrosine kinase activity	0.48345772948903	bayes_pls_golite062009
substrate-specific transmembrane transporter activity	0.450699332958421	bayes_pls_golite062009
protein phosphorylated amino acid binding	0.43808715710519	bayes_pls_golite062009
protein kinase C activity	0.41587987561486	bayes_pls_golite062009
magnesium ion binding	0.393328812780268	bayes_pls_golite062009
MAP kinase kinase kinase activity	0.37115026509016	bayes_pls_golite062009
MAP kinase kinase activity	0.35402045013148	bayes_pls_golite062009
insulin receptor binding	0.266450215230107	bayes_pls_golite062009
transmembrane receptor protein serine/threonine kinase activity	0.26602283402868	bayes_pls_golite062009
transforming growth factor beta receptor activity	0.26602283402868	bayes_pls_golite062009
insulin receptor activity	0.237134032032089	bayes_pls_golite062009
SH2 domain binding	0.226760162354251	bayes_pls_golite062009
ion transmembrane transporter activity	0.148194101970458	bayes_pls_golite062009
growth factor binding	0.0526340287295695	bayes_pls_golite062009
transforming growth factor beta receptor activity, type I	0.0506751594607393	bayes_pls_golite062009
nucleoside-triphosphatase activity	0.0040394359628233	bayes_pls_golite062009

Predicted Domain #5

Region A:
Residues: [957-1016]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PPYIPSLNSP TDTKYFDEEF TRELPVLTPV NSILTKEMQQ HFEGFSYSCE DDKPSTTDNA  60
   61

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	95.221849
Match:	1gznA
Description:	Pkb kinase
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions:

Predicted functions:

Predicted functions: