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View Structure Prediction Details

Protein: LAF2_SCHPO
Organism: Schizosaccharomyces pombe 972h-
Length: 272 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for LAF2_SCHPO.

Description E-value Query
Range
Subject
Range
gi|207340855 - gi|207340855|gb|EDZ69077.1| YOR338Wp-like protein [Saccharomyces cerevisiae AWRI1631]
gi|190407633 - gi|190407633|gb|EDV10900.1| conserved hypothetical protein [Saccharomyces cerevisiae RM11-1a]
YO338_YEAST - SWIRM domain-containing protein YOR338W OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=...
YOR338W - Putative protein of unknown function; YOR338W transcription is regulated by Azf1p and its transcript...
266.0 [0..10] [272..71]
LAF1_SCHPO - SWIRM domain-containing protein laf1 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=laf1 ...
SPAC14C4.12c - SWIRM domain protein
255.0 [0..27] [272..56]
gi|42548007, gi|... - gi|46111819|ref|XP_382967.1| hypothetical protein FG02791.1 [Gibberella zeae PH-1], gi|42548007|gb|E...
254.0 [0..6] [271..121]
gi|32417148, gi|... - gi|38636425|emb|CAE81961.1| conserved hypothetical protein [Neurospora crassa], gi|32417148|ref|XP_3...
gi|85118725 - gi|85118725|ref|XP_965493.1| hypothetical protein [Neurospora crassa OR74A]
254.0 [0..7] [271..135]
gi|44983083, gi|... - gi|45188239|ref|NP_984462.1| ADR366Wp [Ashbya gossypii ATCC 10895], gi|44983083|gb|AAS52286.1| ADR36...
gi|44983083 - gi|44983083|gb|AAS52286.1| ADR366Wp [Ashbya gossypii ATCC 10895]
252.0 [0..2] [251..32]
gi|67537858, gi|... - gi|67537858|ref|XP_662703.1| hypothetical protein AN5099.2 [Aspergillus nidulans FGSC A4], ref|XP_40...
240.0 [0..12] [266..103]
gi|38100815, gi|... - gi|86196147|gb|EAQ70785.1| hypothetical protein MGCH7_ch7g192 [Magnaporthe grisea 70-15], gi|3995567...
238.0 [0..5] [271..126]
gi|18101632 - gi|18101632|gb|AAL14200.2| transcriptional adaptor-like protein [Hypocrea jecorina]
221.0 [0..49] [269..306]

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Predicted Domain #1
Region A:
Residues: [1-190]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MQILKDQENL NPDGGSFVLI TPPLSPPKQK SLSYTNISRR HGMRACMKGI VYEVYKNQPK  60
   61 LWLQQELIWL RRKRIHPIPK ARRNNHVGRW ANRHSNVSSS SGSRGRSSVS SRDSSPSYSG 120
  121 ALRSAERSIS SSPSTIEARR RKSARGNGLN GAIDVANLPF EELPNFCPDM SVLDNRTHPR 180
  181 TLKAEWKGPP 

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [191-272]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LDLSDDPYRD LLHPAELHLA STLRLPCLIY LDNKKRIFAE WHHRRQQGLT FRKTDAQRAS  60
   61 RVDVNKASRL WKAFHEVGFF DD

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 25.221849
Match: 2aqeA
Description: Structural and functional analysis of ada2 alpha swirm domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 5.13863038737912 bayes_pls_golite062009
DNA binding 4.66369707598026 bayes_pls_golite062009
nucleic acid binding 4.51452285155271 bayes_pls_golite062009
transcription factor activity 4.06706589695599 bayes_pls_golite062009
protein deacetylase activity 3.96372663553041 bayes_pls_golite062009
histone deacetylase activity 3.87144180477793 bayes_pls_golite062009
sequence-specific DNA binding 3.5139760613123 bayes_pls_golite062009
deacetylase activity 3.25252407184239 bayes_pls_golite062009
RNA polymerase II transcription factor activity 3.16896789933192 bayes_pls_golite062009
transcription activator activity 3.10621734076555 bayes_pls_golite062009
binding 3.02779747447702 bayes_pls_golite062009
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides 2.16849420369653 bayes_pls_golite062009
transcription repressor activity 1.91962622287073 bayes_pls_golite062009
protein binding 1.88087411289001 bayes_pls_golite062009
specific RNA polymerase II transcription factor activity 1.73068440195944 bayes_pls_golite062009
chromatin binding 1.68956710349366 bayes_pls_golite062009
general RNA polymerase II transcription factor activity 1.62096064323298 bayes_pls_golite062009
transcription factor binding 1.40653841901929 bayes_pls_golite062009
histone acetyltransferase activity 1.40149699217445 bayes_pls_golite062009
lysine N-acetyltransferase activity 1.40149699217445 bayes_pls_golite062009
transcription cofactor activity 0.84983974758882 bayes_pls_golite062009
histone binding 0.557787598121402 bayes_pls_golite062009
telomeric DNA binding 0.284650049512347 bayes_pls_golite062009
transcription coactivator activity 0.2679415219517 bayes_pls_golite062009
transcription corepressor activity 0.25931464844298 bayes_pls_golite062009
cytoskeletal protein binding 0.236060274498333 bayes_pls_golite062009
N-acyltransferase activity 0.212884313176726 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle