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View Structure Prediction Details

Protein: LAF2_SCHPO
Organism: Schizosaccharomyces pombe 972h-
Length: 272 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for LAF2_SCHPO.

Description E-value Query
Range
Subject
Range
gi|207340855 - gi|207340855|gb|EDZ69077.1| YOR338Wp-like protein [Saccharomyces cerevisiae AWRI1631]
gi|190407633 - gi|190407633|gb|EDV10900.1| conserved hypothetical protein [Saccharomyces cerevisiae RM11-1a]
YO338_YEAST - SWIRM domain-containing protein YOR338W OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=...
YOR338W - Putative protein of unknown function; YOR338W transcription is regulated by Azf1p and its transcript...
266.0 [0..10] [272..71]
LAF1_SCHPO - SWIRM domain-containing protein laf1 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=laf1 ...
SPAC14C4.12c - SWIRM domain protein
255.0 [0..27] [272..56]
gi|42548007, gi|... - gi|46111819|ref|XP_382967.1| hypothetical protein FG02791.1 [Gibberella zeae PH-1], gi|42548007|gb|E...
254.0 [0..6] [271..121]
gi|32417148, gi|... - gi|38636425|emb|CAE81961.1| conserved hypothetical protein [Neurospora crassa], gi|32417148|ref|XP_3...
gi|85118725 - gi|85118725|ref|XP_965493.1| hypothetical protein [Neurospora crassa OR74A]
254.0 [0..7] [271..135]
gi|44983083, gi|... - gi|45188239|ref|NP_984462.1| ADR366Wp [Ashbya gossypii ATCC 10895], gi|44983083|gb|AAS52286.1| ADR36...
gi|44983083 - gi|44983083|gb|AAS52286.1| ADR366Wp [Ashbya gossypii ATCC 10895]
252.0 [0..2] [251..32]
gi|67537858, gi|... - gi|67537858|ref|XP_662703.1| hypothetical protein AN5099.2 [Aspergillus nidulans FGSC A4], ref|XP_40...
240.0 [0..12] [266..103]
gi|38100815, gi|... - gi|86196147|gb|EAQ70785.1| hypothetical protein MGCH7_ch7g192 [Magnaporthe grisea 70-15], gi|3995567...
238.0 [0..5] [271..126]
gi|18101632 - gi|18101632|gb|AAL14200.2| transcriptional adaptor-like protein [Hypocrea jecorina]
221.0 [0..49] [269..306]

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Predicted Domain #1
Region A:
Residues: [1-190]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MQILKDQENL NPDGGSFVLI TPPLSPPKQK SLSYTNISRR HGMRACMKGI VYEVYKNQPK  60
   61 LWLQQELIWL RRKRIHPIPK ARRNNHVGRW ANRHSNVSSS SGSRGRSSVS SRDSSPSYSG 120
  121 ALRSAERSIS SSPSTIEARR RKSARGNGLN GAIDVANLPF EELPNFCPDM SVLDNRTHPR 180
  181 TLKAEWKGPP 

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [191-272]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LDLSDDPYRD LLHPAELHLA STLRLPCLIY LDNKKRIFAE WHHRRQQGLT FRKTDAQRAS  60
   61 RVDVNKASRL WKAFHEVGFF DD

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 25.221849
Match: 2aqeA
Description: Structural and functional analysis of ada2 alpha swirm domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 5.13863038737912 bayes_pls_golite062009
DNA binding 4.66369707598026 bayes_pls_golite062009
nucleic acid binding 4.51452285155271 bayes_pls_golite062009
transcription factor activity 4.06706589695599 bayes_pls_golite062009
protein deacetylase activity 3.96372663553041 bayes_pls_golite062009
histone deacetylase activity 3.87144180477793 bayes_pls_golite062009
sequence-specific DNA binding 3.5139760613123 bayes_pls_golite062009
deacetylase activity 3.25252407184239 bayes_pls_golite062009
RNA polymerase II transcription factor activity 3.16896789933192 bayes_pls_golite062009
transcription activator activity 3.10621734076555 bayes_pls_golite062009
binding 3.02779747447702 bayes_pls_golite062009
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides 2.16849420369653 bayes_pls_golite062009
transcription repressor activity 1.91962622287073 bayes_pls_golite062009
protein binding 1.88087411289001 bayes_pls_golite062009
specific RNA polymerase II transcription factor activity 1.73068440195944 bayes_pls_golite062009
chromatin binding 1.68956710349366 bayes_pls_golite062009
general RNA polymerase II transcription factor activity 1.62096064323298 bayes_pls_golite062009
transcription factor binding 1.40653841901929 bayes_pls_golite062009
histone acetyltransferase activity 1.40149699217445 bayes_pls_golite062009
lysine N-acetyltransferase activity 1.40149699217445 bayes_pls_golite062009
transcription cofactor activity 0.84983974758882 bayes_pls_golite062009
histone binding 0.557787598121402 bayes_pls_golite062009
telomeric DNA binding 0.284650049512347 bayes_pls_golite062009
transcription coactivator activity 0.2679415219517 bayes_pls_golite062009
transcription corepressor activity 0.25931464844298 bayes_pls_golite062009
cytoskeletal protein binding 0.236060274498333 bayes_pls_golite062009
N-acyltransferase activity 0.212884313176726 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle