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View Structure Prediction Details

Protein: DDX50
Organism: Homo sapiens
Length: 737 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for DDX50.

Description E-value Query
Range
Subject
Range
gi|114630813 - gi|114630813|ref|XP_507824.2| PREDICTED: nucleolar protein GU2 [Pan troglodytes]
0.0 [1..678] [1..678]
gi|109089503 - gi|109089503|ref|XP_001111043.1| PREDICTED: similar to nucleolar protein GU2 [Macaca mulatta]
ENSCJAT00000037047 - null
0.0 [1..678] [1..678]
gi|73952801 - gi|73952801|ref|XP_850174.1| PREDICTED: similar to nucleolar protein GU2 isoform 2 [Canis familiaris...
0.0 [1..682] [1..683]
gi|21410145 - gi|21410145|gb|AAH30895.1| Ddx21 protein [Mus musculus]
0.0 [55..736] [14..683]
gi|199561314, gi... - gi|199561314|ref|NP_001013216.2| DEAD (Asp-Glu-Ala-Asp) box polypeptide 50 [Rattus norvegicus], gi|1...
0.0 [1..678] [1..675]

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Predicted Domain #1
Region A:
Residues: [1-86]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPGKLLWGDI MELEAPLEES ESQKKERQKS DRRKSRHHYD SDEKSETREN GVTDDLDAPK  60
   61 AKKSKMKEKL NGDTEEGFNR LSDEFS

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [87-157]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KSHKSRRKDL PNGDIDEYEK KSKRVSSLDT STHKSSDNKL EETLTREQKE GAFSNFPISE  60
   61 ETIKLLKGRG V

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 72.30103
Match: 2db3A
Description: No description for 2db3A was found.

Predicted Domain #3
Region A:
Residues: [158-667]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TYLFPIQVKT FGPVYEGKDL IAQARTGTGK TFSFAIPLIE RLQRNQETIK KSRSPKVLVL  60
   61 APTRELANQV AKDFKDITRK LSVACFYGGT SYQSQINHIR NGIDILVGTP GRIKDHLQSG 120
  121 RLDLSKLRHV VLDEVDQMLD LGFAEQVEDI IHESYKTDSE DNPQTLLFSA TCPQWVYKVA 180
  181 KKYMKSRYEQ VDLVGKMTQK AATTVEHLAI QCHWSQRPAV IGDVLQVYSG SEGRAIIFCE 240
  241 TKKNVTEMAM NPHIKQNAQC LHGDIAQSQR EITLKGFREG SFKVLVATNV AARGLDIPEV 300
  301 DLVIQSSPPQ DVESYIHRSG RTGRAGRTGI CICFYQPRER GQLRYVEQKA GITFKRVGVP 360
  361 STMDLVKSKS MDAIRSLASV SYAAVDFFRP SAQRLIEEKG AVDALAAALA HISGASSFEP 420
  421 RSLITSDKGF VTMTLESLEE IQDVSCAWKE LNRKLSSNAV SQITRMCLLK GNMGVCFDVP 480
  481 TTESERLQAE WHDSDWILSV PAKLPEIEEY 

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 17.221849
Match: 2bhrA
Description: Dengue virus RNA helicase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
translation initiation factor activity 7.79457008386475 bayes_pls_golite062009
translation factor activity, nucleic acid binding 4.98637553020315 bayes_pls_golite062009
translation regulator activity 4.94658029227343 bayes_pls_golite062009
4.704140727858 bayes_pls_golite062009
structural constituent of ribosome 4.56509805974548 bayes_pls_golite062009
structural molecule activity 3.58406348799895 bayes_pls_golite062009
nucleoside-triphosphatase activity 2.95079405147356 bayes_pls_golite062009
pyrophosphatase activity 2.87427509025394 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides 2.85499564954033 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 2.85178667290149 bayes_pls_golite062009
motor activity 2.79327761685782 bayes_pls_golite062009
microtubule motor activity 2.74365461017633 bayes_pls_golite062009
binding 2.64537357529343 bayes_pls_golite062009
transporter activity 2.58140740499725 bayes_pls_golite062009
nucleic acid binding 2.51683451033161 bayes_pls_golite062009
transmembrane transporter activity 2.39695871109024 bayes_pls_golite062009
ATPase activity 2.39535714892224 bayes_pls_golite062009
RNA binding 2.29590582680214 bayes_pls_golite062009
ATPase activity, coupled 2.18396165590908 bayes_pls_golite062009
RNA cap binding 2.17871969124431 bayes_pls_golite062009
DNA binding 1.94055378599526 bayes_pls_golite062009
transcription regulator activity 1.83584389083042 bayes_pls_golite062009
helicase activity 1.70242731830224 bayes_pls_golite062009
hydrolase activity 1.57549510726226 bayes_pls_golite062009
protein-DNA loading ATPase activity 1.54436515966471 bayes_pls_golite062009
DNA clamp loader activity 1.51134988628578 bayes_pls_golite062009
RNA helicase activity 1.42791449104435 bayes_pls_golite062009
cytoskeletal protein binding 1.40488517180956 bayes_pls_golite062009
RNA-dependent ATPase activity 1.39335733374328 bayes_pls_golite062009
ATP-dependent RNA helicase activity 1.36724390116598 bayes_pls_golite062009
substrate-specific transporter activity 1.29730375126024 bayes_pls_golite062009
DNA-dependent ATPase activity 1.2155186842031 bayes_pls_golite062009
purine NTP-dependent helicase activity 1.19311444180077 bayes_pls_golite062009
ATP-dependent helicase activity 1.19311444180077 bayes_pls_golite062009
catalytic activity 1.00104173493322 bayes_pls_golite062009
tubulin binding 0.979946830272106 bayes_pls_golite062009
DNA-directed DNA polymerase activity 0.971476020912368 bayes_pls_golite062009
transcription factor activity 0.959949409533517 bayes_pls_golite062009
purine nucleotide binding 0.929901285538132 bayes_pls_golite062009
DNA polymerase activity 0.928091843881235 bayes_pls_golite062009
nucleotide binding 0.922442819194247 bayes_pls_golite062009
purine ribonucleotide binding 0.920987930180051 bayes_pls_golite062009
ribonucleotide binding 0.920926158369519 bayes_pls_golite062009
microtubule binding 0.907162506177187 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 0.906554174337376 bayes_pls_golite062009
actin binding 0.883285269827407 bayes_pls_golite062009
structure-specific DNA binding 0.782430219754236 bayes_pls_golite062009
mRNA binding 0.76699944561918 bayes_pls_golite062009
DNA helicase activity 0.72881469450553 bayes_pls_golite062009
general RNA polymerase II transcription factor activity 0.652333406433794 bayes_pls_golite062009
double-stranded DNA binding 0.6071273686445 bayes_pls_golite062009
transcription repressor activity 0.607045223341107 bayes_pls_golite062009
ATP-dependent DNA helicase activity 0.5886142102548 bayes_pls_golite062009
GTPase activity 0.437665353870877 bayes_pls_golite062009
active transmembrane transporter activity 0.434775387083003 bayes_pls_golite062009
snRNA binding 0.418985924846052 bayes_pls_golite062009
ATP binding 0.41092997612902 bayes_pls_golite062009
adenyl ribonucleotide binding 0.385813421701492 bayes_pls_golite062009
adenyl nucleotide binding 0.377870145186619 bayes_pls_golite062009
ion transmembrane transporter activity 0.355466224802969 bayes_pls_golite062009
guanyl nucleotide binding 0.296406132096546 bayes_pls_golite062009
GTP binding 0.295705904888768 bayes_pls_golite062009
primary active transmembrane transporter activity 0.294474570607914 bayes_pls_golite062009
guanyl ribonucleotide binding 0.29028316917561 bayes_pls_golite062009
P-P-bond-hydrolysis-driven transmembrane transporter activity 0.282352478532746 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances 0.220608508617331 bayes_pls_golite062009
ATPase activity, coupled to transmembrane movement of substances 0.219533217661421 bayes_pls_golite062009
ATPase activity, coupled to movement of substances 0.219157471322311 bayes_pls_golite062009
protein binding 0.170837278876362 bayes_pls_golite062009
microfilament motor activity 0.10236059675512 bayes_pls_golite062009
protein transporter activity 0.0397092337273124 bayes_pls_golite062009
cation transmembrane transporter activity 0.0254369227200564 bayes_pls_golite062009
signal sequence binding 6.53725193420218E-4 bayes_pls_golite062009

Predicted Domain #4
Region A:
Residues: [668-737]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 YDGNTSSNSR QRSGWSSGRS GRSGRSGGRS GGRSGRQSRQ GSRSGSRQDG RRRSGNRNRS  60
   61 RSGGHKRSFD 

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle