YRC Public Data Repository - Protein Structure Prediction

Protein:	CSNK1D
Organism:	Homo sapiens
Length:	415 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for CSNK1D.

Description	E-value	Query Range	Subject Range
KC1D_MOUSE - Casein kinase I isoform delta OS=Mus musculus GN=Csnk1d PE=1 SV=2 gi\|117616262 - gi\|117616262\|gb\|ABK42149.1\| casein kinase I delta [synthetic construct] KC1D_RAT - Casein kinase I isoform delta OS=Rattus norvegicus GN=Csnk1d PE=1 SV=2	6.0E-89	[1..415]	[1..415]
gi\|33303939 - gi\|33303939\|gb\|AAQ02477.1\| casein kinase 1, delta [synthetic construct]	8.0E-89	[1..415]	[1..415]
gi\|881619, gi\|15... - gi\|881619\|gb\|AAC50807.1\| casein kinase I delta, pir\|\|G01876 casein kinase I delta - human, gi\|15883...	1.0E-88	[1..415]	[1..415]
KC1D_PONAB - Casein kinase I isoform delta OS=Pongo abelii GN=CSNK1D PE=2 SV=1 gi\|55727769 - gi\|55727769\|emb\|CAH90635.1\| hypothetical protein [Pongo abelii]	2.0E-88	[1..415]	[1..415]
gi\|50757757 - gi\|50757757\|ref\|XP_415634.1\| PREDICTED: similar to Casein kinase 1, delta, isoform 1 [Gallus gallus]	4.0E-87	[1..415]	[1..415]
KC1D_XENTR - Casein kinase I isoform delta OS=Xenopus tropicalis GN=csnk1d PE=2 SV=1	6.0E-87	[1..415]	[1..415]
gi\|148229581, gi... - gi\|60499545\|gb\|AAX22003.1\| casein kinase I delta [Xenopus laevis], gi\|148229581\|ref\|NP_001080669.1\| ...	1.0E-86	[1..415]	[1..415]
gi\|114671110 - gi\|114671110\|ref\|XP_511761.2\| PREDICTED: casein kinase 1, delta isoform 4 [Pan troglodytes]	5.0E-84	[1..400]	[1..400]
gi\|76645405 - gi\|76645405\|ref\|XP_601842.2\| PREDICTED: similar to Casein kinase I, delta isoform (CKI-delta) isofor...	3.0E-83	[1..407]	[1..407]

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Predicted Domain #1

Region A:
Residues: [1-298]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MELRVGNRYR LGRKIGSGSF GDIYLGTDIA AGEEVAIKLE CVKTKHPQLH IESKIYKMMQ  60
   61 GGVGIPTIRW CGAEGDYNVM VMELLGPSLE DLFNFCSRKF SLKTVLLLAD QMISRIEYIH 120
  121 SKNFIHRDVK PDNFLMGLGK KGNLVYIIDF GLAKKYRDAR THQHIPYREN KNLTGTARYA 180
  181 SINTHLGIEQ SRRDDLESLG YVLMYFNLGS LPWQGLKAAT KRQKYERISE KKMSTPIEVL 240
  241 CKGYPSEFAT YLNFCRSLRF DDKPDYSYLR QLFRNLFHRQ GFSYDYVFDW NMLKFGAS

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	69.522879
Match:	1ckiA
Description:	Casein kinase-1, CK1
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
phosphotransferase activity, alcohol group as acceptor	5.49988294224815	bayes_pls_golite062009
protein kinase activity	5.4586557943719	bayes_pls_golite062009
kinase activity	5.3287080791198	bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups	4.96052051118534	bayes_pls_golite062009
protein serine/threonine kinase activity	4.46381887831481	bayes_pls_golite062009
transferase activity	3.97138602499442	bayes_pls_golite062009
binding	2.74863538127007	bayes_pls_golite062009
tubulin binding	2.18641675163967	bayes_pls_golite062009
cytoskeletal protein binding	2.12615078788254	bayes_pls_golite062009
ATP binding	1.97600611746091	bayes_pls_golite062009
adenyl ribonucleotide binding	1.93596671856664	bayes_pls_golite062009
adenyl nucleotide binding	1.90928021591891	bayes_pls_golite062009
microtubule binding	1.88110801192607	bayes_pls_golite062009
purine ribonucleotide binding	1.65732943334212	bayes_pls_golite062009
ribonucleotide binding	1.65726906484847	bayes_pls_golite062009
purine nucleotide binding	1.63763394711025	bayes_pls_golite062009
nucleotide binding	1.63195828048121	bayes_pls_golite062009
protein tyrosine kinase activity	1.3898059094397	bayes_pls_golite062009
receptor signaling protein serine/threonine kinase activity	1.38496328649031	bayes_pls_golite062009
actin binding	1.33479685165255	bayes_pls_golite062009
receptor signaling protein activity	1.27291233344322	bayes_pls_golite062009
protein binding	1.22565748038754	bayes_pls_golite062009
catalytic activity	1.21655087018101	bayes_pls_golite062009
transmembrane receptor activity	0.913893847407112	bayes_pls_golite062009
transmembrane receptor protein kinase activity	0.821371946077904	bayes_pls_golite062009
nucleic acid binding	0.794058505655489	bayes_pls_golite062009
transcription regulator activity	0.775404673285876	bayes_pls_golite062009
receptor activity	0.775180603313375	bayes_pls_golite062009
DNA binding	0.714163549867672	bayes_pls_golite062009
structural constituent of cytoskeleton	0.612883428421652	bayes_pls_golite062009
transcription factor activity	0.563262875317016	bayes_pls_golite062009
cyclin-dependent protein kinase activity	0.499492353295369	bayes_pls_golite062009
protein serine/threonine/tyrosine kinase activity	0.48345772948903	bayes_pls_golite062009
transmembrane receptor protein tyrosine kinase activity	0.461392047923247	bayes_pls_golite062009
nucleoside-triphosphatase activity	0.410563074162143	bayes_pls_golite062009
magnesium ion binding	0.393328812780268	bayes_pls_golite062009
MAP kinase kinase kinase activity	0.37115026509016	bayes_pls_golite062009
pyrophosphatase activity	0.370400538296802	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides	0.359826512663547	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	0.359163657047398	bayes_pls_golite062009
MAP kinase kinase activity	0.35402045013148	bayes_pls_golite062009
signal transducer activity	0.270054246024761	bayes_pls_golite062009
molecular transducer activity	0.270054246024761	bayes_pls_golite062009
MAP kinase activity	0.26024936404169	bayes_pls_golite062009
actin filament binding	0.2403700250846	bayes_pls_golite062009
protein kinase C activity	0.0795689006739899	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [299-415]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RAADDAERER RDREERLRHS RNPATRGLPS TASGRLRGTQ EVAPPTPLTP TSHTANTSPR  60
   61 PVSGMERERK VSMRLHRGAP VNISSSDLTG RQDTSRMSTS QIPGRVASSG LQSVVHR

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: