| Protein: | PRPF19 |
| Organism: | Homo sapiens |
| Length: | 504 amino acids |
| Reference: | Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16 |
Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for PRPF19.
| Description | E-value | Query Range |
Subject Range |
|
|
0.0 | [10..504] | [1242..1747] |
|
|
0.0 | [10..504] | [1072..1575] |
|
|
0.0 | [10..503] | [638..1143] |
|
|
0.0 | [45..504] | [1023..1481] |
|
|
0.0 | [1..503] | [741..1247] |
|
|
0.0 | [38..503] | [937..1401] |
|
Region A: Residues: [1-64] |
1 11 21 31 41 51
| | | | | |
1 MSLICSISNE VPEHPCVSPV SNHVYERRLI EKYIAENGTD PINNQPLSEE QLIDIKVAHP 60
61 IRPK
|
| Detection Method: |  |
| Confidence: | 4.28 |
| Match: | 1wgmA |
| Description: | Solution structure of the U-box in human ubiquitin conjugation factor E4A |
Matching Structure (courtesy of the PDB): |
|
| Term | Confidence | Notes |
| ubiquitin-protein ligase activity | 9.85513873918659 | bayes_pls_golite062009 |
| small conjugating protein ligase activity | 9.6498820226444 | bayes_pls_golite062009 |
| acid-amino acid ligase activity | 8.65014213775678 | bayes_pls_golite062009 |
| ligase activity, forming carbon-nitrogen bonds | 7.41958646938187 | bayes_pls_golite062009 |
| 4.72885746116757 | bayes_pls_golite062009 | |
| ligase activity | 3.71574519150582 | bayes_pls_golite062009 |
| RNA binding | 3.00624142341404 | bayes_pls_golite062009 |
| binding | 2.70912934275371 | bayes_pls_golite062009 |
| transcription regulator activity | 2.69310847474187 | bayes_pls_golite062009 |
| protein binding | 2.53639372327734 | bayes_pls_golite062009 |
| nucleic acid binding | 2.31493818053907 | bayes_pls_golite062009 |
| DNA binding | 2.0126776192216 | bayes_pls_golite062009 |
| SUMO polymer binding | 1.98746860482839 | bayes_pls_golite062009 |
| transcription repressor activity | 1.91556680192956 | bayes_pls_golite062009 |
| SMAD binding | 1.71970331089852 | bayes_pls_golite062009 |
| transcription factor activity | 1.23220438818624 | bayes_pls_golite062009 |
| ubiquitin-ubiquitin ligase activity | 1.03473176569589 | bayes_pls_golite062009 |
| small conjugating protein-specific protease activity | 1.02238152139385 | bayes_pls_golite062009 |
| transcription factor binding | 0.987482369490121 | bayes_pls_golite062009 |
| general RNA polymerase II transcription factor activity | 0.937930843160931 | bayes_pls_golite062009 |
| ubiquitin-specific protease activity | 0.821040441472875 | bayes_pls_golite062009 |
| copper ion binding | 0.622487660255715 | bayes_pls_golite062009 |
| hydrolase activity | 0.552260876472222 | bayes_pls_golite062009 |
| cysteine-type peptidase activity | 0.356312424125648 | bayes_pls_golite062009 |
| transcription corepressor activity | 0.308921486763847 | bayes_pls_golite062009 |
| metal ion binding | 0.18132240757103 | bayes_pls_golite062009 |
| cation binding | 0.18132240757103 | bayes_pls_golite062009 |
| ion binding | 0.176492524214768 | bayes_pls_golite062009 |
| catalytic activity | 0.168711389690753 | bayes_pls_golite062009 |
| transcription cofactor activity | 0.137379573046724 | bayes_pls_golite062009 |
| transcription activator activity | 0.111490592727037 | bayes_pls_golite062009 |
| transition metal ion binding | 0.0854849739238891 | bayes_pls_golite062009 |
| enzyme binding | 0.0252200602272163 | bayes_pls_golite062009 |
| ubiquitin thiolesterase activity | 0.0136579100966835 | bayes_pls_golite062009 |
|
Region A: Residues: [65-202] |
1 11 21 31 41 51
| | | | | |
1 PPSATSIPAI LKALQDEWDA VMLHSFTLRQ QLQTTRQELS HALYQHDAAC RVIARLTKEV 60
61 TAAREALATL KPQAGLIVPQ AVPSSQPSVV GAGEPMDLGE LVGMTPEIIQ KLQDKATVLT 120
121 TERKKRGKTV PEELVKPE
|
| Detection Method: | |
| Confidence: | 40.148742 |
| Match: | PF08606.2 |
| Description: | No description for PF08606.2 was found. |
Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.
| MCM Score |
GO Score |
GO Term |
SCOP Match |
SCOP Description | ||
| View | Download | 0.273 | 0.080 | protein ubiquitination | a.45.1 | Glutathione S-transferase (GST), C-terminal domain |
| View | Download | 0.359 | 0.075 | protein ubiquitination | a.25.1 | Ferritin-like |
| View | Download | 0.263 | 0.048 | DNA repair | a.74.1 | Cyclin-like |
| View | Download | 0.268 | 0.006 | protein ubiquitination | a.24.16 | Nucleotidyltransferase substrate binding subunit/domain |
| View | Download | 0.386 | 0.005 | protein ubiquitination | a.24.17 | Group V grass pollen allergen |
|
Region A: Residues: [203-504] |
1 11 21 31 41 51
| | | | | |
1 ELSKYRQVAS HVGLHSASIP GILALDLCPS DTNKILTGGA DKNVVVFDKS SEQILATLKG 60
61 HTKKVTSVVF HPSQDLVFSA SPDATIRIWS VPNASCVQVV RAHESAVTGL SLHATGDYLL 120
121 SSSDDQYWAF SDIQTGRVLT KVTDETSGCS LTCAQFHPDG LIFGTGTMDS QIKIWDLKER 180
181 TNVANFPGHS GPITSIAFSE NGYYLATAAD DSSVKLWDLR KLKNFKTLQL DNNFEVKSLI 240
241 FDQSGTYLAL GGTDVQIYIC KQWTEILHFT EHSGLTTGVA FGHHAKFIAS TGMDRSLKFY 300
301 SL
|
| Detection Method: | |
| Confidence: | 69.69897 |
| Match: | 1vyhC |
| Description: | PAF-AH Holoenzyme: Lis1/Alfa2 |
Matching Structure (courtesy of the PDB): |
|
| Term | Confidence | Notes |
| ubiquitin-protein ligase activity | 7.6976390971701 | bayes_pls_golite062009 |
| small conjugating protein ligase activity | 7.38724968585043 | bayes_pls_golite062009 |
| 6.67009948605948 | bayes_pls_golite062009 | |
| acid-amino acid ligase activity | 6.41826641115519 | bayes_pls_golite062009 |
| ligase activity, forming carbon-nitrogen bonds | 5.36089569430187 | bayes_pls_golite062009 |
| actin binding | 3.86142918698875 | bayes_pls_golite062009 |
| RNA binding | 3.77273677738815 | bayes_pls_golite062009 |
| GTPase activity | 3.23750443966606 | bayes_pls_golite062009 |
| cytoskeletal protein binding | 3.1056443224755 | bayes_pls_golite062009 |
| tubulin binding | 2.76945430061825 | bayes_pls_golite062009 |
| microtubule binding | 2.72684103222924 | bayes_pls_golite062009 |
| dynein binding | 2.54821997913979 | bayes_pls_golite062009 |
| binding | 2.42570478946173 | bayes_pls_golite062009 |
| transcription regulator activity | 2.3610959773142 | bayes_pls_golite062009 |
| nucleic acid binding | 2.30918780727915 | bayes_pls_golite062009 |
| transcription repressor activity | 2.29049708962212 | bayes_pls_golite062009 |
| snoRNA binding | 2.27164613239345 | bayes_pls_golite062009 |
| protein binding | 2.26925404328312 | bayes_pls_golite062009 |
| actin filament binding | 2.0735069176589 | bayes_pls_golite062009 |
| dynactin binding | 1.92897254169098 | bayes_pls_golite062009 |
| ligase activity | 1.82531515493699 | bayes_pls_golite062009 |
| DNA binding | 1.71685536470455 | bayes_pls_golite062009 |
| structural molecule activity | 1.47097979074281 | bayes_pls_golite062009 |
| transcription corepressor activity | 1.41752877005447 | bayes_pls_golite062009 |
| transporter activity | 1.21549336905926 | bayes_pls_golite062009 |
| receptor activity | 1.12819778129653 | bayes_pls_golite062009 |
| G-protein-coupled receptor binding | 1.11754260203517 | bayes_pls_golite062009 |
| transcription factor activity | 1.08768505897883 | bayes_pls_golite062009 |
| mRNA binding | 1.05053985350578 | bayes_pls_golite062009 |
| microtubule plus-end binding | 1.01166033978052 | bayes_pls_golite062009 |
| myosin binding | 0.989691178611801 | bayes_pls_golite062009 |
| molecular transducer activity | 0.974380908248463 | bayes_pls_golite062009 |
| signal transducer activity | 0.974380908248463 | bayes_pls_golite062009 |
| protein transporter activity | 0.964340340346761 | bayes_pls_golite062009 |
| type 1 angiotensin receptor binding | 0.920323565472959 | bayes_pls_golite062009 |
| angiotensin receptor binding | 0.920323565472959 | bayes_pls_golite062009 |
| substrate-specific transporter activity | 0.734793983890004 | bayes_pls_golite062009 |
| transcription factor binding | 0.489473003915035 | bayes_pls_golite062009 |
| dynein intermediate chain binding | 0.443846546939402 | bayes_pls_golite062009 |
| phosphotransferase activity, alcohol group as acceptor | 0.426429095658617 | bayes_pls_golite062009 |
| kinase activity | 0.387572734234845 | bayes_pls_golite062009 |
| transcription cofactor activity | 0.30761651528651 | bayes_pls_golite062009 |
| myosin heavy chain kinase activity | 0.231534552000461 | bayes_pls_golite062009 |
| protein kinase activity | 0.229242350006544 | bayes_pls_golite062009 |
| transferase activity, transferring phosphorus-containing groups | 0.226335610368636 | bayes_pls_golite062009 |
| hydrolase activity | 0.181211933860468 | bayes_pls_golite062009 |
| histone binding | 0.166694897714113 | bayes_pls_golite062009 |
| general RNA polymerase II transcription factor activity | 0.132660456600365 | bayes_pls_golite062009 |
| structural constituent of cytoskeleton | 0.118975415284669 | bayes_pls_golite062009 |
| receptor binding | 0.0390635451962911 | bayes_pls_golite062009 |
| myosin II binding | 0.0145748031956598 | bayes_pls_golite062009 |
| nucleoside-triphosphatase activity | 0.00585398682921312 | bayes_pls_golite062009 |
