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Protein Overview: PRPF19

General Information:
Name(s) found: PRPF19 [HGNC (HUGO)]
Description(s) found:
Found 36 descriptions.
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  • PRP19/PSO4 pre-mRNA processing factor 19 homolog (S. cerevisiae) [HGNC (HUGO)]
    • Organism: Homo sapiens
    Length: 504 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: NONE FOUND
    Molecular Function: NONE FOUND


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSLICSISNE VPEHPCVSPV SNHVYERRLI EKYIAENGTD PINNQPLSEE QLIDIKVAHP  60
   61 IRPKPPSATS IPAILKALQD EWDAVMLHSF TLRQQLQTTR QELSHALYQH DAACRVIARL 120
  121 TKEVTAAREA LATLKPQAGL IVPQAVPSSQ PSVVGAGEPM DLGELVGMTP EIIQKLQDKA 180
  181 TVLTTERKKR GKTVPEELVK PEELSKYRQV ASHVGLHSAS IPGILALDLC PSDTNKILTG 240
  241 GADKNVVVFD KSSEQILATL KGHTKKVTSV VFHPSQDLVF SASPDATIRI WSVPNASCVQ 300
  301 VVRAHESAVT GLSLHATGDY LLSSSDDQYW AFSDIQTGRV LTKVTDETSG CSLTCAQFHP 360
  361 DGLIFGTGTM DSQIKIWDLK ERTNVANFPG HSGPITSIAF SENGYYLATA ADDSSVKLWD 420
  421 LRKLKNFKTL QLDNNFEVKS LIFDQSGTYL ALGGTDVQIY ICKQWTEILH FTEHSGLTTG 480
  481 VAFGHHAKFI ASTGMDRSLK FYSL

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run gi|14317902, gi|... No Comments Cheeseman, I.M., et al. (2004)
    View Run MIS12 No Comments Cheeseman, I.M., et al. (2004)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..64] FFAS03 4.28 Solution structure of the U-box in human ubiquitin conjugation factor E4A
    2 View Details [65..202] Pfam 40.148742 No description for PF08606.2 was found. No confident structure predictions are available.
    3 View Details [203..504] PSI-BLAST 69.69897 PAF-AH Holoenzyme: Lis1/Alfa2

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • ubiquitin-protein ligase activity
    		•  9.85513873918659 bayes_pls_golite062009
  • small conjugating protein ligase activity
    		•  9.6498820226444 bayes_pls_golite062009
  • acid-amino acid ligase activity
    		•  8.65014213775678 bayes_pls_golite062009
  • ligase activity, forming carbon-nitrogen bonds
    		•  7.41958646938187 bayes_pls_golite062009
    		• 4.72885746116757 bayes_pls_golite062009
  • ligase activity
    		•  3.71574519150582 bayes_pls_golite062009
  • RNA binding
    		•  3.00624142341404 bayes_pls_golite062009
  • binding
    		•  2.70912934275371 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.69310847474187 bayes_pls_golite062009
  • protein binding
    		•  2.53639372327734 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.31493818053907 bayes_pls_golite062009
  • DNA binding
    		•  2.0126776192216 bayes_pls_golite062009
  • SUMO polymer binding
    		•  1.98746860482839 bayes_pls_golite062009
  • transcription repressor activity
    		•  1.91556680192956 bayes_pls_golite062009
  • SMAD binding
    		•  1.71970331089852 bayes_pls_golite062009
  • transcription factor activity
    		•  1.23220438818624 bayes_pls_golite062009
  • ubiquitin-ubiquitin ligase activity
    		•  1.03473176569589 bayes_pls_golite062009
  • small conjugating protein-specific protease activity
    		•  1.02238152139385 bayes_pls_golite062009
  • transcription factor binding
    		•  0.987482369490121 bayes_pls_golite062009
  • general RNA polymerase II transcription factor activity
    		•  0.937930843160931 bayes_pls_golite062009
  • ubiquitin-specific protease activity
    		•  0.821040441472875 bayes_pls_golite062009
  • copper ion binding
    		•  0.622487660255715 bayes_pls_golite062009
  • hydrolase activity
    		•  0.552260876472222 bayes_pls_golite062009
  • cysteine-type peptidase activity
    		•  0.356312424125648 bayes_pls_golite062009
  • transcription corepressor activity
    		•  0.308921486763847 bayes_pls_golite062009
  • metal ion binding
    		•  0.18132240757103 bayes_pls_golite062009
  • cation binding
    		•  0.18132240757103 bayes_pls_golite062009
  • ion binding
    		•  0.176492524214768 bayes_pls_golite062009
  • catalytic activity
    		•  0.168711389690753 bayes_pls_golite062009
  • transcription cofactor activity
    		•  0.137379573046724 bayes_pls_golite062009
  • transcription activator activity
    		•  0.111490592727037 bayes_pls_golite062009
  • transition metal ion binding
    		•  0.0854849739238891 bayes_pls_golite062009
  • enzyme binding
    		•  0.0252200602272163 bayes_pls_golite062009
  • ubiquitin thiolesterase activity
    		•  0.0136579100966835 bayes_pls_golite062009
    2 No functions predicted.
    3
    Term Confidence Notes
  • ubiquitin-protein ligase activity
    		•  7.6976390971701 bayes_pls_golite062009
  • small conjugating protein ligase activity
    		•  7.38724968585043 bayes_pls_golite062009
    		• 6.67009948605948 bayes_pls_golite062009
  • acid-amino acid ligase activity
    		•  6.41826641115519 bayes_pls_golite062009
  • ligase activity, forming carbon-nitrogen bonds
    		•  5.36089569430187 bayes_pls_golite062009
  • actin binding
    		•  3.86142918698875 bayes_pls_golite062009
  • RNA binding
    		•  3.77273677738815 bayes_pls_golite062009
  • GTPase activity
    		•  3.23750443966606 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  3.1056443224755 bayes_pls_golite062009
  • tubulin binding
    		•  2.76945430061825 bayes_pls_golite062009
  • microtubule binding
    		•  2.72684103222924 bayes_pls_golite062009
  • dynein binding
    		•  2.54821997913979 bayes_pls_golite062009
  • binding
    		•  2.42570478946173 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.3610959773142 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.30918780727915 bayes_pls_golite062009
  • transcription repressor activity
    		•  2.29049708962212 bayes_pls_golite062009
  • snoRNA binding
    		•  2.27164613239345 bayes_pls_golite062009
  • protein binding
    		•  2.26925404328312 bayes_pls_golite062009
  • actin filament binding
    		•  2.0735069176589 bayes_pls_golite062009
  • dynactin binding
    		•  1.92897254169098 bayes_pls_golite062009
  • ligase activity
    		•  1.82531515493699 bayes_pls_golite062009
  • DNA binding
    		•  1.71685536470455 bayes_pls_golite062009
  • structural molecule activity
    		•  1.47097979074281 bayes_pls_golite062009
  • transcription corepressor activity
    		•  1.41752877005447 bayes_pls_golite062009
  • transporter activity
    		•  1.21549336905926 bayes_pls_golite062009
  • receptor activity
    		•  1.12819778129653 bayes_pls_golite062009
  • G-protein-coupled receptor binding
    		•  1.11754260203517 bayes_pls_golite062009
  • transcription factor activity
    		•  1.08768505897883 bayes_pls_golite062009
  • mRNA binding
    		•  1.05053985350578 bayes_pls_golite062009
  • microtubule plus-end binding
    		•  1.01166033978052 bayes_pls_golite062009
  • myosin binding
    		•  0.989691178611801 bayes_pls_golite062009
  • molecular transducer activity
    		•  0.974380908248463 bayes_pls_golite062009
  • signal transducer activity
    		•  0.974380908248463 bayes_pls_golite062009
  • protein transporter activity
    		•  0.964340340346761 bayes_pls_golite062009
  • type 1 angiotensin receptor binding
    		•  0.920323565472959 bayes_pls_golite062009
  • angiotensin receptor binding
    		•  0.920323565472959 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.734793983890004 bayes_pls_golite062009
  • transcription factor binding
    		•  0.489473003915035 bayes_pls_golite062009
  • dynein intermediate chain binding
    		•  0.443846546939402 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  0.426429095658617 bayes_pls_golite062009
  • kinase activity
    		•  0.387572734234845 bayes_pls_golite062009
  • transcription cofactor activity
    		•  0.30761651528651 bayes_pls_golite062009
  • myosin heavy chain kinase activity
    		•  0.231534552000461 bayes_pls_golite062009
  • protein kinase activity
    		•  0.229242350006544 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  0.226335610368636 bayes_pls_golite062009
  • hydrolase activity
    		•  0.181211933860468 bayes_pls_golite062009
  • histone binding
    		•  0.166694897714113 bayes_pls_golite062009
  • general RNA polymerase II transcription factor activity
    		•  0.132660456600365 bayes_pls_golite062009
  • structural constituent of cytoskeleton
    		•  0.118975415284669 bayes_pls_golite062009
  • receptor binding
    		•  0.0390635451962911 bayes_pls_golite062009
  • myosin II binding
    		•  0.0145748031956598 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  0.00585398682921312 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle