YRC Public Data Repository - Protein Structure Prediction

Protein:	CYP2C8
Organism:	Homo sapiens
Length:	490 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for CYP2C8.

Description	E-value	Query Range	Subject Range
CP2CK_MACFA - Cytochrome P450 2C20 OS=Macaca fascicularis GN=CYP2C20 PE=2 SV=1	0.0	[1..490]	[1..490]
gi\|18088282 - gi\|18088282\|gb\|AAH20596.1\| Cytochrome P450, family 2, subfamily C, polypeptide 8 [Homo sapiens] gi\|123980994, gi... - gi\|123995807\|gb\|ABM85505.1\| cytochrome P450, family 2, subfamily C, polypeptide 8 [synthetic constru...	0.0	[1..490]	[1..490]
gi\|66731521 - gi\|66731521\|gb\|AAY51973.1\| cytochrome P450 2C8 [Cercopithecus aethiops]	0.0	[1..490]	[1..490]
gi\|94158944, gi\|... - gi\|94158944\|ref\|NP_001035300.1\| cytochrome P450, family 2, subfamily C, polypeptide 8 [Macaca mulatt...	0.0	[1..490]	[1..490]
gi\|114631924 - gi\|114631924\|ref\|XP_001153207.1\| PREDICTED: similar to Cytochrome P450 2C8 (CYPIIC8) (P450 form 1) (...	0.0	[1..490]	[1..490]
CP2CP_MESAU - Cytochrome P450 2C25 OS=Mesocricetus auratus GN=CYP2C25 PE=2 SV=1	0.0	[1..490]	[1..490]
gi\|115496944, gi... - gi\|94574282\|gb\|AAI16042.1\| Cytochrome P450, family 2, subfamily C, polypeptide 18 [Bos taurus], gi\|1...	0.0	[20..490]	[20..490]
gi\|441052 - gi\|441052\|dbj\|BAA05139.1\| cytochrome P-450 [Oryctolagus cuniculus]	0.0	[1..490]	[1..489]

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Predicted Domain #1

Region A:
Residues: [1-490]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MEPFVVLVLC LSFMLLFSLW RQSCRRRKLP PGPTPLPIIG NMLQIDVKDI CKSFTNFSKV  60
   61 YGPVFTVYFG MNPIVVFHGY EAVKEALIDN GEEFSGRGNS PISQRITKGL GIISSNGKRW 120
  121 KEIRRFSLTT LRNFGMGKRS IEDRVQEEAH CLVEELRKTK ASPCDPTFIL GCAPCNVICS 180
  181 VVFQKRFDYK DQNFLTLMKR FNENFRILNS PWIQVCNNFP LLIDCFPGTH NKVLKNVALT 240
  241 RSYIREKVKE HQASLDVNNP RDFIDCFLIK MEQEKDNQKS EFNIENLVGT VADLFVAGTE 300
  301 TTSTTLRYGL LLLLKHPEVT AKVQEEIDHV IGRHRSPCMQ DRSHMPYTDA VVHEIQRYSD 360
  361 LVPTGVPHAV TTDTKFRNYL IPKGTTIMAL LTSVLHDDKE FPNPNIFDPG HFLDKNGNFK 420
  421 KSDYFMPFSA GKRICAGEGL ARMELFLFLT TILQNFNLKS VDDLKNLNTT AVTKGIVSLP 480
  481 PSYQICFIPV

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	119.0
Match:	1pq2A
Description:	Crystal Structure of Human Drug Metabolizing Cytochrome P450 2C8
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
arachidonic acid monooxygenase activity	6.76823710927794	bayes_pls_golite062009
monooxygenase activity	5.57229509004705	bayes_pls_golite062009
steroid hydroxylase activity	5.04794778387361	bayes_pls_golite062009
arachidonic acid epoxygenase activity	4.80764258881036	bayes_pls_golite062009
electron carrier activity	4.64931978461551	bayes_pls_golite062009
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen	4.64322346579269	bayes_pls_golite062009
steroid 17-alpha-monooxygenase activity	3.99744233006162	bayes_pls_golite062009
retinoic acid 4-hydroxylase activity	3.76307535769621	bayes_pls_golite062009
oxygen binding	3.7203678182299	bayes_pls_golite062009
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	3.68151610133025	bayes_pls_golite062009
demethylase activity	3.40807632433846	bayes_pls_golite062009
sterol 14-demethylase activity	2.94610675710811	bayes_pls_golite062009
retinoic acid binding	2.70323898361882	bayes_pls_golite062009
retinoid binding	2.60220937953757	bayes_pls_golite062009
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	2.56821164444595	bayes_pls_golite062009
isoprenoid binding	2.47826119804163	bayes_pls_golite062009
oxysterol 7-alpha-hydroxylase activity	2.36480328243514	bayes_pls_golite062009
oxidoreductase activity	2.35847923992364	bayes_pls_golite062009
1-alpha,25-dihydroxyvitamin D3 24-hydroxylase activity	2.30416050662077	bayes_pls_golite062009
steroid 7-alpha-hydroxylase activity	2.21042366294727	bayes_pls_golite062009
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen	2.15105968497418	bayes_pls_golite062009
ecdysteroid 25-hydroxylase activity	2.0071742914584	bayes_pls_golite062009
vitamin D 24-hydroxylase activity	1.81919676974797	bayes_pls_golite062009
flavonoid 3'-monooxygenase activity	1.71233606135238	bayes_pls_golite062009
vitamin D3 25-hydroxylase activity	1.65825585934141	bayes_pls_golite062009
vitamin D 25-hydroxylase activity	1.65825585934141	bayes_pls_golite062009
fatty acid (omega-1)-hydroxylase activity	1.65569090470706	bayes_pls_golite062009
corticosterone 18-monooxygenase activity	1.64204907906991	bayes_pls_golite062009
steroid 11-beta-monooxygenase activity	1.64204907906991	bayes_pls_golite062009
testosterone 6-beta-hydroxylase activity	1.4661447981611	bayes_pls_golite062009
binding	1.2866152532988	bayes_pls_golite062009
25-hydroxycholecalciferol-24-hydroxylase activity	1.06487564122685	bayes_pls_golite062009
ecdysteroid 22-hydroxylase activity	0.7601272997427	bayes_pls_golite062009
catalytic activity	0.608111453189583	bayes_pls_golite062009
cholesterol monooxygenase (side-chain-cleaving) activity	0.276594551871869	bayes_pls_golite062009
arachidonic acid 11,12-epoxygenase activity	0.0888154993183798	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: