YRC Public Data Repository - Protein Structure Prediction

Protein:	SAR1
Organism:	Saccharomyces cerevisiae
Length:	190 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for SAR1.

Description	E-value	Query Range	Subject Range
tr\|G1TXQ6\|G1TXQ6... - pep:novel scaffold:oryCun2:GL019112:79657:80606:-1 gene:ENSOCUG00000023645 transcript:ENSOCUT0000002... ARF1_MACFA - ADP-ribosylation factor 1 OS=Macaca fascicularis GN=ARF1 PE=2 SV=3 ENSCJAT00000032503 - null gi\|168277944, gi... - gi\|61362573\|gb\|AAX42245.1\| ADP-ribosylation factor 1 [synthetic construct], gi\|61362566\|gb\|AAX42244.... gi\|542165806\|ref... - PREDICTED: ADP-ribosylation factor 1 [Zonotrichia albicollis] ARF1 - ADP-ribosylation factor 1 gi\|149759398 - gi\|149759398\|ref\|XP_001494680.1\| PREDICTED: similar to ADP-ribosylation factor 1 isoform 1 [Equus ca... gi\|242247455, gi... - gi\|242247455\|ref\|NP_001156016.1\| ADP-ribosylation factor 1 [Ovis aries], gi\|238799786\|gb\|ACR55765.1\|... ARF1_MOUSE - ADP-ribosylation factor 1 OS=Mus musculus GN=Arf1 PE=1 SV=2 gi\|50732153 - ref\|XP_418504.1\| PREDICTED: similar to ADP-ribosylation factor 1 [Gallus gallus] ARF1_RAT - ADP-ribosylation factor 1 OS=Rattus norvegicus GN=Arf1 PE=1 SV=2 ARF1_BOVIN - ADP-ribosylation factor 1 OS=Bos taurus GN=ARF1 PE=1 SV=2 gi\|224044540 - gi\|224044540\|ref\|XP_002194825.1\| PREDICTED: ADP-ribosylation factor 1 [Taeniopygia guttata] gi\|212725657, gi... - gi\|238018148\|ref\|NP_001153899.1\| ADP-ribosylation factor 1 [Sus scrofa], gi\|237638742\|gb\|ACR07973.1\|... CCDS1565.1_1 - null gi\|114573018, gi... - gi\|114573032\|ref\|XP_001145210.1\| PREDICTED: similar to ADP-ribosylation factor isoform 14 [Pan trogl... ENSMMUG000000027... - null, null gi\|120577632 - gi\|120577632\|gb\|AAI30157.1\| Arf-1 protein [Xenopus laevis]	5.0E-62	[6..190]	[1..177]
gi\|194154824, gi... - gi\|195377781\|ref\|XP_002047666.1\| GJ13559 [Drosophila virilis], gi\|194154824\|gb\|EDW70008.1\| GJ13559 [... gi\|194164570, gi... - gi\|195441372\|ref\|XP_002068485.1\| GK20496 [Drosophila willistoni], gi\|194164570\|gb\|EDW79471.1\| GK2049... gi\|195496824, gi... - gi\|195496824\|ref\|XP_002095857.1\| GE19486 [Drosophila yakuba], gi\|194181958\|gb\|EDW95569.1\| GE19486 [D... gi\|194197957, gi... - gi\|195592450\|ref\|XP_002085948.1\| GD12049 [Drosophila simulans], gi\|194197957\|gb\|EDX11533.1\| GD12049 ... gi\|220943938, gi... - gi\|220953814\|gb\|ACL89450.1\| Arf79F-PA [synthetic construct], gi\|220943938\|gb\|ACL84512.1\| Arf79F-PA [... AGAP012014-PA, A... - Arf1: ADP-ribosylation factor 1\|protein_coding\|3L:36310085:36311000:1\|gene:AGAP012014, Arf1: ADP-rib... gi\|167878418, gi... - gi\|170035930\|ref\|XP_001845819.1\| ADP-ribosylation factor 1 [Culex quinquefasciatus], gi\|167878418\|gb... gi\|194752565, gi... - gi\|194752565\|ref\|XP_001958592.1\| GF23441 [Drosophila ananassae], gi\|190625874\|gb\|EDV41398.1\| GF23441... gi\|194876431, gi... - gi\|194876431\|ref\|XP_001973775.1\| GG13164 [Drosophila erecta], gi\|190655558\|gb\|EDV52801.1\| GG13164 [D... ARF1_LOCMI - ADP-ribosylation factor 1 OS=Locusta migratoria GN=ARF1 PE=2 SV=2 gi\|195019299, gi... - gi\|195019299\|ref\|XP_001984951.1\| GH14762 [Drosophila grimshawi], gi\|193898433\|gb\|EDV97299.1\| GH14762... gi\|125978691, gi... - gi\|54642136\|gb\|EAL30885.1\| GA21036 [Drosophila pseudoobscura pseudoobscura], gi\|125978691\|ref\|XP_001... gi\|193919952, gi... - gi\|195127774\|ref\|XP_002008343.1\| GI11864 [Drosophila mojavensis], gi\|193919952\|gb\|EDW18819.1\| GI1186... gi\|55234664, gi\|... - gi\|58394100\|ref\|XP_320516.2\| AGAP012014-PA [Anopheles gambiae str. PEST], gi\|55234664\|gb\|EAA00461.2\|... gi\|195160571, gi... - gi\|195160571\|ref\|XP_002021149.1\| GL25178 [Drosophila persimilis], gi\|194118262\|gb\|EDW40305.1\| GL2517... gi\|195348855, gi... - gi\|195348855\|ref\|XP_002040963.1\| GM22073 [Drosophila sechellia], gi\|194122473\|gb\|EDW44516.1\| GM22073... gi\|108877049, gi... - gi\|94468810\|gb\|ABF18254.1\| GTP-binding ADP-ribosylation factor Arf1 [Aedes aegypti], gi\|157115009\|re... gi\|125978691\|ref... - GA21036-PA [Drosophila pseudoobscura], GA21036 [Drosophila pseudoobscura pseudoobscura] Arf79F-PA, FBpp0... - The gene ADP ribosylation factor 79F is referred to in FlyBase by the symbol Dmel\Arf79F (CG8385, FB...	1.0E-61	[6..190]	[1..177]
gi\|51703673, gi\|... - gi\|89271853\|emb\|CAJ81862.1\| ADP-ribosylation factor 1 [Xenopus tropicalis], gi\|51703673\|gb\|AAH80915.... gi\|94966418, gi\|... - gi\|94966418\|dbj\|BAE94175.1\| ADP ribosylation factor 1 [Xenopus laevis], gi\|27503439\|gb\|AAH42337.1\| A...	1.0E-61	[6..190]	[1..177]
ARF2_MOUSE - ADP-ribosylation factor 2 OS=Mus musculus GN=Arf2 PE=1 SV=2 ARF2_BOVIN - ADP-ribosylation factor 2 OS=Bos taurus GN=ARF2 PE=2 SV=1 gi\|149723672 - gi\|149723672\|ref\|XP_001487896.1\| PREDICTED: similar to ADP-ribosylation factor 2 [Equus caballus] tr\|M3X5P7\|M3X5P7... - Uncharacterized protein OS=Felis catus GN=LOC101089059 PE=3 SV=1 ARF2_RAT - ADP-ribosylation factor 2 OS=Rattus norvegicus GN=Arf2 PE=2 SV=1	2.0E-61	[6..190]	[1..177]
gi\|41393117, gi\|... - gi\|46403253\|gb\|AAS92646.1\| ADP-ribosylation factor 1 [Danio rerio], gi\|41393117\|ref\|NP_958888.1\| ADP...	2.0E-61	[6..190]	[1..177]
arf-1.2 - ARF status:Confirmed UniProt:Q10943 protein_id:AAK18851.1	8.0E-61	[6..190]	[1..177]

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Predicted Domain #1

Region A:
Residues: [1-190]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAGWDIFGWF RDVLASLGLW NKHGKLLFLG LDNAGKTTLL HMLKNDRLAT LQPTWHPTSE  60
   61 ELAIGNIKFT TFDLGGHIQA RRLWKDYFPE VNGIVFLVDA ADPERFDEAR VELDALFNIA 120
  121 ELKDVPFVIL GNKIDAPNAV SEAELRSALG LLNTTGSQRI EGQRPVEVFM CSVVMRNGYL 180
  181 EAFQWLSQYI

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	1122.154902
Match:	1m2oB_
Description:	SAR1
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
motor activity	3.3674051903467	bayes_pls_golite062009
transporter activity	3.10463051760206	bayes_pls_golite062009
transmembrane transporter activity	2.95886887664984	bayes_pls_golite062009
nucleoside-triphosphatase activity	2.95079405147356	bayes_pls_golite062009
microtubule motor activity	2.9037759597776	bayes_pls_golite062009
pyrophosphatase activity	2.87427509025394	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides	2.85499564954033	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	2.85178667290149	bayes_pls_golite062009
primary active transmembrane transporter activity	2.61775212528604	bayes_pls_golite062009
P-P-bond-hydrolysis-driven transmembrane transporter activity	2.61467977505707	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances	2.57552435627908	bayes_pls_golite062009
ATPase activity, coupled to transmembrane movement of substances	2.57107347424517	bayes_pls_golite062009
ATPase activity, coupled to movement of substances	2.57054427875021	bayes_pls_golite062009
microfilament motor activity	2.51786963027655	bayes_pls_golite062009
active transmembrane transporter activity	2.50494515048649	bayes_pls_golite062009
ATPase activity, coupled	2.43862163407966	bayes_pls_golite062009
cytoskeletal protein binding	2.4101693596493	bayes_pls_golite062009
ATPase activity	2.39535714892224	bayes_pls_golite062009
actin binding	2.2973522188675	bayes_pls_golite062009
amine transmembrane transporter activity	2.29486577878686	bayes_pls_golite062009
binding	2.21604035604783	bayes_pls_golite062009
substrate-specific transporter activity	1.91091452720653	bayes_pls_golite062009
guanyl nucleotide binding	1.89320355239381	bayes_pls_golite062009
guanyl ribonucleotide binding	1.88721318481223	bayes_pls_golite062009
GTP binding	1.87900088157196	bayes_pls_golite062009
alpha-tubulin binding	1.792591628112	bayes_pls_golite062009
organic acid transmembrane transporter activity	1.77111739879769	bayes_pls_golite062009
carboxylic acid transmembrane transporter activity	1.75695995185278	bayes_pls_golite062009
protein transporter activity	1.71214667007262	bayes_pls_golite062009
GTPase activity	1.6309422514633	bayes_pls_golite062009
tubulin binding	1.62788446088451	bayes_pls_golite062009
hydrolase activity	1.57549510726226	bayes_pls_golite062009
substrate-specific transmembrane transporter activity	1.56325751172863	bayes_pls_golite062009
nucleic acid binding	1.51655225251251	bayes_pls_golite062009
transcription regulator activity	1.49517431175162	bayes_pls_golite062009
signal recognition particle binding	1.46975774710831	bayes_pls_golite062009
microtubule binding	1.44471873069962	bayes_pls_golite062009
DNA binding	1.28683669571887	bayes_pls_golite062009
actin filament binding	1.28204719195916	bayes_pls_golite062009
protein binding	1.22129154759482	bayes_pls_golite062009
catalytic activity	1.00104173493322	bayes_pls_golite062009
ATP binding	0.98146619596929	bayes_pls_golite062009
ion transmembrane transporter activity	0.977237423302079	bayes_pls_golite062009
adenyl ribonucleotide binding	0.949788783884952	bayes_pls_golite062009
RNA helicase activity	0.94708387424268	bayes_pls_golite062009
adenyl nucleotide binding	0.931486373329219	bayes_pls_golite062009
ATP-dependent RNA helicase activity	0.93133090558732	bayes_pls_golite062009
purine nucleotide binding	0.929901285538132	bayes_pls_golite062009
nucleotide binding	0.922442819194247	bayes_pls_golite062009
actin-dependent ATPase activity	0.92105578610354	bayes_pls_golite062009
purine ribonucleotide binding	0.920987930180051	bayes_pls_golite062009
ribonucleotide binding	0.920926158369519	bayes_pls_golite062009
RNA-dependent ATPase activity	0.91827876091109	bayes_pls_golite062009
kinase activity	0.691112783105676	bayes_pls_golite062009
molecular transducer activity	0.683309012097319	bayes_pls_golite062009
signal transducer activity	0.683309012097319	bayes_pls_golite062009
amino acid transmembrane transporter activity	0.585668369219566	bayes_pls_golite062009
cation transmembrane transporter activity	0.557919489256916	bayes_pls_golite062009
ribonucleoprotein binding	0.53788302029845	bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups	0.499834566483656	bayes_pls_golite062009
drug transmembrane transporter activity	0.38711726712063	bayes_pls_golite062009
transition metal ion transmembrane transporter activity	0.305627755818843	bayes_pls_golite062009
plus-end-directed microtubule motor activity	0.267845390391521	bayes_pls_golite062009
protein kinase activity	0.214608777661308	bayes_pls_golite062009
hydrogen ion transporting ATP synthase activity, rotational mechanism	0.213018989352421	bayes_pls_golite062009
structural constituent of ribosome	0.208665086324262	bayes_pls_golite062009
transcription factor activity	0.139974763025221	bayes_pls_golite062009
inorganic cation transmembrane transporter activity	0.123304946374679	bayes_pls_golite062009
beta-tubulin binding	0.115598037081252	bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor	0.0430764033739892	bayes_pls_golite062009
structural constituent of cytoskeleton	0.0111338193708552	bayes_pls_golite062009
dynein binding	0.00615444901942652	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: