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View Structure Prediction Details

Protein: ERG5
Organism: Saccharomyces cerevisiae
Length: 538 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for ERG5.

Description E-value Query
Range
Subject
Range
C93A1_SOYBN - 3,9-dihydroxypterocarpan 6A-monooxygenase OS=Glycine max GN=CYP93A1 PE=1 SV=1
0.0 [39..529] [1..502]
F3PH_ARATH - Flavonoid 3'-monooxygenase OS=Arabidopsis thaliana GN=CYP75B1 PE=1 SV=1
0.0 [43..531] [4..504]
gi|12331298 - gi|12331298|emb|CAC24711.1| cytochrome P450 [Solanum tuberosum]
0.0 [43..531] [3..499]
C71A1_PERAE - Cytochrome P450 71A1 OS=Persea americana GN=CYP71A1 PE=1 SV=2
0.0 [39..531] [1..502]
gi|12231914 - gi|12231914|gb|AAG49315.1|AF315465_1 flavonoid 3'-hydroxylase [Pelargonium x hortorum]
0.0 [37..533] [1..509]
gi|14423327 - gi|14423327|gb|AAK62346.1| elicitor-inducible cytochrome P450 [Nicotiana tabacum]
0.0 [37..531] [1..503]

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Predicted Domain #1
Region A:
Residues: [1-80]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSSVAENIIQ HATHNSTLHQ LAKDQPSVGV TTAFSILDTL KSMSYLKIFA TLICILLVWD  60
   61 QVAYQIKKGS IAGPKFKFWP 

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score
SCOP
Match
SCOP Description
View Download 0.343 a.39.1 EF-hand
View Download 0.360 a.4.5 "Winged helix" DNA-binding domain
View Download 0.349 a.3.1 Cytochrome c
View Download 0.504 a.4.6 C-terminal effector domain of the bipartite response regulators
View Download 0.581 a.4.6 C-terminal effector domain of the bipartite response regulators
View Download 0.370 a.52.1 Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin
View Download 0.455 a.23.5 Hemolysin expression modulating protein HHA
View Download 0.341 a.35.1 lambda repressor-like DNA-binding domains
View Download 0.322 a.47.2 t-snare proteins
View Download 0.312 a.100.1 6-phosphogluconate dehydrogenase C-terminal domain-like
View Download 0.294 d.55.1 Ribosomal protein L22
View Download 0.293 a.35.1 lambda repressor-like DNA-binding domains
View Download 0.291 a.4.5 "Winged helix" DNA-binding domain
View Download 0.289 a.74.1 Cyclin-like
View Download 0.282 a.35.1 lambda repressor-like DNA-binding domains
View Download 0.280 a.24.17 Group V grass pollen allergen
View Download 0.275 a.77.1 DEATH domain
View Download 0.270 a.52.1 Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin
View Download 0.268 a.29.2 Bromodomain
View Download 0.267 a.4.6 C-terminal effector domain of the bipartite response regulators
View Download 0.262 a.118.1 ARM repeat
View Download 0.262 a.4.1 Homeodomain-like
View Download 0.258 a.65.1 Annexin
View Download 0.258 a.4.1 Homeodomain-like
View Download 0.251 d.26.1 FKBP-like
View Download 0.241 a.39.1 EF-hand
View Download 0.237 a.163.1 Crustacean CHH/MIH/GIH neurohormone
View Download 0.237 a.60.5 Barrier-to-autointegration factor, BAF
View Download 0.234 a.118.13 Arp2/3 complex 16 kDa subunit ARPC5
View Download 0.233 a.4.5 "Winged helix" DNA-binding domain
View Download 0.232 a.3.1 Cytochrome c
View Download 0.231 a.80.1 DNA polymerase III clamp loader subunits, C-terminal domain
View Download 0.228 a.100.1 6-phosphogluconate dehydrogenase C-terminal domain-like
View Download 0.228 a.65.1 Annexin
View Download 0.227 a.71.1 Endoplasmic reticulum protein ERP29, C-domain
View Download 0.225 a.7.2 Enzyme IIa from lactose specific PTS, IIa-lac
View Download 0.225 a.46.1 Methionine synthase domain
View Download 0.219 a.4.5 "Winged helix" DNA-binding domain
View Download 0.214 d.50.3 PI-Pfui intein middle domain
View Download 0.212 a.118.13 Arp2/3 complex 16 kDa subunit ARPC5
View Download 0.211 a.39.1 EF-hand
View Download 0.209 a.100.1 6-phosphogluconate dehydrogenase C-terminal domain-like
View Download 0.201 a.60.13 Putative methyltransferase TM0872, insert domain

Predicted functions:

Term Confidence Notes
arachidonic acid monooxygenase activity 6.76823710927794 bayes_pls_golite062009
monooxygenase activity 5.57229509004705 bayes_pls_golite062009
steroid hydroxylase activity 5.04794778387361 bayes_pls_golite062009
arachidonic acid epoxygenase activity 4.80764258881036 bayes_pls_golite062009
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen 4.64322346579269 bayes_pls_golite062009
steroid 17-alpha-monooxygenase activity 3.99744233006162 bayes_pls_golite062009
retinoic acid 4-hydroxylase activity 3.76307535769621 bayes_pls_golite062009
demethylase activity 3.40807632433846 bayes_pls_golite062009
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen 3.24344797738248 bayes_pls_golite062009
retinoic acid binding 3.04897926497756 bayes_pls_golite062009
sterol 14-demethylase activity 2.94610675710811 bayes_pls_golite062009
oxygen binding 2.77495508953933 bayes_pls_golite062009
retinoid binding 2.60220937953757 bayes_pls_golite062009
isoprenoid binding 2.47826119804163 bayes_pls_golite062009
oxysterol 7-alpha-hydroxylase activity 2.36480328243514 bayes_pls_golite062009
oxidoreductase activity 2.35847923992364 bayes_pls_golite062009
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen 1.97593187367475 bayes_pls_golite062009
fatty acid (omega-1)-hydroxylase activity 1.65569090470706 bayes_pls_golite062009
corticosterone 18-monooxygenase activity 1.64204907906991 bayes_pls_golite062009
steroid 11-beta-monooxygenase activity 1.64204907906991 bayes_pls_golite062009
electron carrier activity 1.48516712188486 bayes_pls_golite062009
binding 1.2866152532988 bayes_pls_golite062009
1-alpha,25-dihydroxyvitamin D3 24-hydroxylase activity 0.658520486133281 bayes_pls_golite062009
catalytic activity 0.608111453189583 bayes_pls_golite062009
testosterone 6-beta-hydroxylase activity 0.38659560844654 bayes_pls_golite062009
cholesterol monooxygenase (side-chain-cleaving) activity 0.276594551871869 bayes_pls_golite062009
arachidonic acid 11,12-epoxygenase activity 0.0888154993183798 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [81-139]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 IIGPFLESLD PKFEEYKAKW ASGPLSCVSI FHKFVVIAST RDLARKILQS SKFVKPCVV

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [210-214]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EMREI

[Run NCBI BLAST on this sequence.]

Region C:
Residues: [337-344]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SQDASSSL

[Run NCBI BLAST on this sequence.]

Region D:
Residues: [398-444]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RYRPPVLMVP YVVKKNFPVS PNYTAPKGAM LIPTLYPALH DPEVYEN

[Run NCBI BLAST on this sequence.]

Region E:
Residues: [461-484]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EAKKNWLVFG CGPHVCLGQT YVMI

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 167.9691
Match: 1jo9A_
Description: No description for 1jo9A_ was found.

Predicted Domain #3
Region A:
Residues: [140-183]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DVAVKILRPC NWVFLDGKAH TDYRKSLNGL FTKQALAQYL PSLE

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [215-336]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LCALSLNSFC GNYITEDQVR KIADDYYLVT AALELVNFPI IIPYTKTWYG KKTADMAMKI  60
   61 FENCAQMAKD HIAAGGKPVC VMDAWCKLMH DAKNSNDDDS RIYHREFTNK EISEAVFTFL 120
  121 FA

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 167.9691
Match: 1jo9A_
Description: No description for 1jo9A_ was found.

Predicted Domain #4
Region A:
Residues: [184-209]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QIMDKYMDKF VRLSKENNYE PQVFFH

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [345-397]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ACWLFQIVAD RPDVLAKIRE EQLAVRNNDM STELNLDLIE KMKYTNMVIK ETL

[Run NCBI BLAST on this sequence.]

Region C:
Residues: [445-460]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PDEFIPERWV EGSKAS

[Run NCBI BLAST on this sequence.]

Region D:
Residues: [485-538]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TFAALLGKFA LYTDFHHTVT PLSEKIKVFA TIFPKDDLLL TFKKRDPITG EVFE

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 167.9691
Match: 1jo9A_
Description: No description for 1jo9A_ was found.

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle