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View Structure Prediction Details

Protein: ERG5
Organism: Saccharomyces cerevisiae
Length: 538 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for ERG5.

Description E-value Query
Range		 Subject
Range
C93A1_SOYBN - 3,9-dihydroxypterocarpan 6A-monooxygenase OS=Glycine max GN=CYP93A1 PE=1 SV=1
 0.0 [39..529] [1..502]
F3PH_ARATH - Flavonoid 3'-monooxygenase OS=Arabidopsis thaliana GN=CYP75B1 PE=1 SV=1
 0.0 [43..531] [4..504]
gi|12331298 - gi|12331298|emb|CAC24711.1| cytochrome P450 [Solanum tuberosum]
 0.0 [43..531] [3..499]
C71A1_PERAE - Cytochrome P450 71A1 OS=Persea americana GN=CYP71A1 PE=1 SV=2
 0.0 [39..531] [1..502]
gi|12231914 - gi|12231914|gb|AAG49315.1|AF315465_1 flavonoid 3'-hydroxylase [Pelargonium x hortorum]
 0.0 [37..533] [1..509]
gi|14423327 - gi|14423327|gb|AAK62346.1| elicitor-inducible cytochrome P450 [Nicotiana tabacum]
 0.0 [37..531] [1..503]

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Predicted Domain #1
Region A:
Residues: [1-80] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSSVAENIIQ HATHNSTLHQ LAKDQPSVGV TTAFSILDTL KSMSYLKIFA TLICILLVWD  60
   61 QVAYQIKKGS IAGPKFKFWP

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted functions:

Term Confidence Notes
arachidonic acid monooxygenase activity 6.76823710927794 bayes_pls_golite062009
monooxygenase activity 5.57229509004705 bayes_pls_golite062009
steroid hydroxylase activity 5.04794778387361 bayes_pls_golite062009
arachidonic acid epoxygenase activity 4.80764258881036 bayes_pls_golite062009
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen 4.64322346579269 bayes_pls_golite062009
steroid 17-alpha-monooxygenase activity 3.99744233006162 bayes_pls_golite062009
retinoic acid 4-hydroxylase activity 3.76307535769621 bayes_pls_golite062009
demethylase activity 3.40807632433846 bayes_pls_golite062009
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen 3.24344797738248 bayes_pls_golite062009
retinoic acid binding 3.04897926497756 bayes_pls_golite062009
sterol 14-demethylase activity 2.94610675710811 bayes_pls_golite062009
oxygen binding 2.77495508953933 bayes_pls_golite062009
retinoid binding 2.60220937953757 bayes_pls_golite062009
isoprenoid binding 2.47826119804163 bayes_pls_golite062009
oxysterol 7-alpha-hydroxylase activity 2.36480328243514 bayes_pls_golite062009
oxidoreductase activity 2.35847923992364 bayes_pls_golite062009
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen 1.97593187367475 bayes_pls_golite062009
fatty acid (omega-1)-hydroxylase activity 1.65569090470706 bayes_pls_golite062009
corticosterone 18-monooxygenase activity 1.64204907906991 bayes_pls_golite062009
steroid 11-beta-monooxygenase activity 1.64204907906991 bayes_pls_golite062009
electron carrier activity 1.48516712188486 bayes_pls_golite062009
binding 1.2866152532988 bayes_pls_golite062009
1-alpha,25-dihydroxyvitamin D3 24-hydroxylase activity 0.658520486133281 bayes_pls_golite062009
catalytic activity 0.608111453189583 bayes_pls_golite062009
testosterone 6-beta-hydroxylase activity 0.38659560844654 bayes_pls_golite062009
cholesterol monooxygenase (side-chain-cleaving) activity 0.276594551871869 bayes_pls_golite062009
arachidonic acid 11,12-epoxygenase activity 0.0888154993183798 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [81-139] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 IIGPFLESLD PKFEEYKAKW ASGPLSCVSI FHKFVVIAST RDLARKILQS SKFVKPCVV

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [210-214] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EMREI

[Run NCBI BLAST on this sequence.]

Region C:
Residues: [337-344] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SQDASSSL

[Run NCBI BLAST on this sequence.]

Region D:
Residues: [398-444] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RYRPPVLMVP YVVKKNFPVS PNYTAPKGAM LIPTLYPALH DPEVYEN

[Run NCBI BLAST on this sequence.]

Region E:
Residues: [461-484] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EAKKNWLVFG CGPHVCLGQT YVMI

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 167.9691
Match: 1jo9A_
Description: No description for 1jo9A_ was found.

Predicted Domain #3
Region A:
Residues: [140-183] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DVAVKILRPC NWVFLDGKAH TDYRKSLNGL FTKQALAQYL PSLE

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [215-336] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LCALSLNSFC GNYITEDQVR KIADDYYLVT AALELVNFPI IIPYTKTWYG KKTADMAMKI  60
   61 FENCAQMAKD HIAAGGKPVC VMDAWCKLMH DAKNSNDDDS RIYHREFTNK EISEAVFTFL 120
  121 FA

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 167.9691
Match: 1jo9A_
Description: No description for 1jo9A_ was found.

Predicted Domain #4
Region A:
Residues: [184-209] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QIMDKYMDKF VRLSKENNYE PQVFFH

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [345-397] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ACWLFQIVAD RPDVLAKIRE EQLAVRNNDM STELNLDLIE KMKYTNMVIK ETL

[Run NCBI BLAST on this sequence.]

Region C:
Residues: [445-460] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PDEFIPERWV EGSKAS

[Run NCBI BLAST on this sequence.]

Region D:
Residues: [485-538] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TFAALLGKFA LYTDFHHTVT PLSEKIKVFA TIFPKDDLLL TFKKRDPITG EVFE

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 167.9691
Match: 1jo9A_
Description: No description for 1jo9A_ was found.
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle