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Protein Overview: ERG5

General Information:
Name(s) found: ERG5 / YMR015C [SGD]
Description(s) found:
Found 31 descriptions.
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  • C-22 sterol desaturase, a cytochrome P450 enzyme that catalyzes the formation of the C-22(23) double bond in the sterol side chain in ergosterol biosynthesis; may be a target of azole antifungal drugs [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 538 amino acids

    Gene Ontology:
    Cellular Component: endoplasmic reticulum [TAS]
    Biological Process: ergosterol biosynthetic process [TAS]
    Molecular Function: C-22 sterol desaturase activity [TAS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSSVAENIIQ HATHNSTLHQ LAKDQPSVGV TTAFSILDTL KSMSYLKIFA TLICILLVWD  60
   61 QVAYQIKKGS IAGPKFKFWP IIGPFLESLD PKFEEYKAKW ASGPLSCVSI FHKFVVIAST 120
  121 RDLARKILQS SKFVKPCVVD VAVKILRPCN WVFLDGKAHT DYRKSLNGLF TKQALAQYLP 180
  181 SLEQIMDKYM DKFVRLSKEN NYEPQVFFHE MREILCALSL NSFCGNYITE DQVRKIADDY 240
  241 YLVTAALELV NFPIIIPYTK TWYGKKTADM AMKIFENCAQ MAKDHIAAGG KPVCVMDAWC 300
  301 KLMHDAKNSN DDDSRIYHRE FTNKEISEAV FTFLFASQDA SSSLACWLFQ IVADRPDVLA 360
  361 KIREEQLAVR NNDMSTELNL DLIEKMKYTN MVIKETLRYR PPVLMVPYVV KKNFPVSPNY 420
  421 TAPKGAMLIP TLYPALHDPE VYENPDEFIP ERWVEGSKAS EAKKNWLVFG CGPHVCLGQT 480
  481 YVMITFAALL GKFALYTDFH HTVTPLSEKI KVFATIFPKD DLLLTFKKRD PITGEVFE

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data ERG5 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..80] deduced N/A No confident structure predictions are available.
    2 View Details [81..139]
    [210..214]
    [337..344]
    [398..444]
    [461..484]    		 PSI-BLAST 167.9691 No description for 1jo9A_ was found.
    3 View Details [140..183]
    [215..336]    		 PSI-BLAST 167.9691 No description for 1jo9A_ was found.
    4 View Details [184..209]
    [345..397]
    [445..460]
    [485..538]    		 PSI-BLAST 167.9691 No description for 1jo9A_ was found.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • arachidonic acid monooxygenase activity
    		•  6.76823710927794 bayes_pls_golite062009
  • monooxygenase activity
    		•  5.57229509004705 bayes_pls_golite062009
  • steroid hydroxylase activity
    		•  5.04794778387361 bayes_pls_golite062009
  • arachidonic acid epoxygenase activity
    		•  4.80764258881036 bayes_pls_golite062009
  • oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen
    		•  4.64322346579269 bayes_pls_golite062009
  • steroid 17-alpha-monooxygenase activity
    		•  3.99744233006162 bayes_pls_golite062009
  • retinoic acid 4-hydroxylase activity
    		•  3.76307535769621 bayes_pls_golite062009
  • demethylase activity
    		•  3.40807632433846 bayes_pls_golite062009
  • oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
    		•  3.24344797738248 bayes_pls_golite062009
  • retinoic acid binding
    		•  3.04897926497756 bayes_pls_golite062009
  • sterol 14-demethylase activity
    		•  2.94610675710811 bayes_pls_golite062009
  • oxygen binding
    		•  2.77495508953933 bayes_pls_golite062009
  • retinoid binding
    		•  2.60220937953757 bayes_pls_golite062009
  • isoprenoid binding
    		•  2.47826119804163 bayes_pls_golite062009
  • oxysterol 7-alpha-hydroxylase activity
    		•  2.36480328243514 bayes_pls_golite062009
  • oxidoreductase activity
    		•  2.35847923992364 bayes_pls_golite062009
  • oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
    		•  1.97593187367475 bayes_pls_golite062009
  • fatty acid (omega-1)-hydroxylase activity
    		•  1.65569090470706 bayes_pls_golite062009
  • corticosterone 18-monooxygenase activity
    		•  1.64204907906991 bayes_pls_golite062009
  • steroid 11-beta-monooxygenase activity
    		•  1.64204907906991 bayes_pls_golite062009
  • electron carrier activity
    		•  1.48516712188486 bayes_pls_golite062009
  • binding
    		•  1.2866152532988 bayes_pls_golite062009
  • 1-alpha,25-dihydroxyvitamin D3 24-hydroxylase activity
    		•  0.658520486133281 bayes_pls_golite062009
  • catalytic activity
    		•  0.608111453189583 bayes_pls_golite062009
  • testosterone 6-beta-hydroxylase activity
    		•  0.38659560844654 bayes_pls_golite062009
  • cholesterol monooxygenase (side-chain-cleaving) activity
    		•  0.276594551871869 bayes_pls_golite062009
  • arachidonic acid 11,12-epoxygenase activity
    		•  0.0888154993183798 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.
    4 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.63

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle