| Protein: | SMC3 |
| Organism: | Saccharomyces cerevisiae |
| Length: | 1230 amino acids |
| Reference: | Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076 |
Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for SMC3.
| Description | E-value | Query Range |
Subject Range |
|
|
0.0 | [1..1230] | [1..1230] |
|
|
0.0 | [52..1093] | [867..1936] |
|
|
0.0 | [52..1093] | [870..1939] |
|
|
0.0 | [52..1095] | [870..1941] |
|
|
0.0 | [52..1093] | [869..1938] |
|
|
0.0 | [52..1095] | [867..1938] |
|
Region A: Residues: [1-50] |
1 11 21 31 41 51
| | | | | |
1 MYIKRVIIKG FKTYRNETII DNFSPHQNVI IGSNGSGKSN FFAAIRFVLS
|
| Detection Method: |  |
| Confidence: | 2.69897 |
| Match: | 1br2A_ |
| Description: | Myosin S1 fragment, N-terminal domain; Myosin S1, motor domain |
Matching Structure (courtesy of the PDB): |
|
| Term | Confidence | Notes |
| microtubule motor activity | 4.51968578934603 | bayes_pls_golite062009 |
| motor activity | 4.04927796049806 | bayes_pls_golite062009 |
| DNA-dependent ATPase activity | 2.72462789867829 | bayes_pls_golite062009 |
| tubulin binding | 2.67743463093593 | bayes_pls_golite062009 |
| binding | 2.64537357529343 | bayes_pls_golite062009 |
| microtubule binding | 2.59155206524122 | bayes_pls_golite062009 |
| cytoskeletal protein binding | 2.4101693596493 | bayes_pls_golite062009 |
| DNA helicase activity | 2.2817164193758 | bayes_pls_golite062009 |
| nucleoside-triphosphatase activity | 2.16381244011837 | bayes_pls_golite062009 |
| pyrophosphatase activity | 2.13284212711072 | bayes_pls_golite062009 |
| hydrolase activity, acting on acid anhydrides | 2.11265775498161 | bayes_pls_golite062009 |
| hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 2.11046854230259 | bayes_pls_golite062009 |
| ATP-dependent DNA helicase activity | 1.88455339138556 | bayes_pls_golite062009 |
| actin binding | 1.75397031486306 | bayes_pls_golite062009 |
| helicase activity | 1.70242731830224 | bayes_pls_golite062009 |
| hydrolase activity | 1.66122526893602 | bayes_pls_golite062009 |
| ATPase activity | 1.53315090215319 | bayes_pls_golite062009 |
| plus-end-directed microtubule motor activity | 1.38366133153678 | bayes_pls_golite062009 |
| protein-DNA loading ATPase activity | 1.29640539057136 | bayes_pls_golite062009 |
| structure-specific DNA binding | 1.2539059700735 | bayes_pls_golite062009 |
| bubble DNA binding | 1.24175604630882 | bayes_pls_golite062009 |
| microfilament motor activity | 1.20923670094205 | bayes_pls_golite062009 |
| purine NTP-dependent helicase activity | 1.19311444180077 | bayes_pls_golite062009 |
| ATP-dependent helicase activity | 1.19311444180077 | bayes_pls_golite062009 |
| DNA clamp loader activity | 1.12431517057397 | bayes_pls_golite062009 |
| double-stranded DNA binding | 1.117585097627 | bayes_pls_golite062009 |
| nucleic acid binding | 1.08697924060619 | bayes_pls_golite062009 |
| catalytic activity | 1.00104173493322 | bayes_pls_golite062009 |
| actin filament binding | 0.728264616959762 | bayes_pls_golite062009 |
| DNA binding | 0.702147676354075 | bayes_pls_golite062009 |
| single-stranded DNA binding | 0.568457189190858 | bayes_pls_golite062009 |
| recombinase activity | 0.45851158693664 | bayes_pls_golite062009 |
| purine nucleotide binding | 0.442941451960958 | bayes_pls_golite062009 |
| purine ribonucleotide binding | 0.440672169804309 | bayes_pls_golite062009 |
| ribonucleotide binding | 0.440612929099368 | bayes_pls_golite062009 |
| nucleotide binding | 0.433111366205869 | bayes_pls_golite062009 |
| RNA helicase activity | 0.34746349346164 | bayes_pls_golite062009 |
| centromeric DNA binding | 0.322818640526369 | bayes_pls_golite062009 |
| transcription regulator activity | 0.312171320541728 | bayes_pls_golite062009 |
| mismatched DNA binding | 0.31144582840038 | bayes_pls_golite062009 |
| ATP-dependent RNA helicase activity | 0.30832907234141 | bayes_pls_golite062009 |
| RNA-dependent ATPase activity | 0.29532978396745 | bayes_pls_golite062009 |
| four-way junction helicase activity | 0.26252931460003 | bayes_pls_golite062009 |
| exodeoxyribonuclease V activity | 0.185603938981231 | bayes_pls_golite062009 |
| protein binding | 0.170837278876362 | bayes_pls_golite062009 |
| 3'-5' DNA helicase activity | 0.0769112340058804 | bayes_pls_golite062009 |
| structural constituent of cytoskeleton | 0.0111338193708552 | bayes_pls_golite062009 |
|
Region A: Residues: [51-394] |
1 11 21 31 41 51
| | | | | |
1 DDYSNLKREE RQGLIHQGSG GSVMSASVEI VFHDPDHSMI LPSGVLSRGD DEVTIRRTVG 60
61 LKKDDYQLND RNVTKGDIVR MLETAGFSMN NPYNIVPQGK IVALTNAKDK ERLQLLEDVV 120
121 GAKSFEVKLK ASLKKMEETE QKKIQINKEM GELNSKLSEM EQERKELEKY NELERNRKIY 180
181 QFTLYDRELN EVINQMERLD GDYNNTVYSS EQYIQELDKR EDMIDQVSKK LSSIEASLKI 240
241 KNATDLQQAK LRESEISQKL TNVNVKIKDV QQQIESNEEQ RNLDSATLKE IKSIIEQRKQ 300
301 KLSKILPRYQ ELTKEEAMYK LQLASLQQKQ RDLILKKGEY ARFK
|
| Detection Method: | |
| Confidence: | 22.522879 |
| Match: | 1i84S_ |
| Description: | Heavy meromyosin subfragment |
Matching Structure (courtesy of the PDB): |
|
|
Region A: Residues: [395-451] |
1 11 21 31 41 51
| | | | | |
1 SKDERDTWIH SEIEELKSSI QNLNELESQL QMDRTSLRKQ YSAIDEEIEE LIDSING
|
| Detection Method: | |
Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.
Found no confident structure predictions for this domain.
| Term | Confidence | Notes |
| binding | 3.01984970042125 | bayes_pls_golite062009 |
| protein heterodimerization activity | 1.35977617500621 | bayes_pls_golite062009 |
| DNA secondary structure binding | 1.33504054478953 | bayes_pls_golite062009 |
| structure-specific DNA binding | 1.32955290929194 | bayes_pls_golite062009 |
| double-stranded DNA binding | 1.12641995595394 | bayes_pls_golite062009 |
| protein binding | 1.08760961845332 | bayes_pls_golite062009 |
| protein dimerization activity | 0.966666737816339 | bayes_pls_golite062009 |
| nucleic acid binding | 0.835977072951553 | bayes_pls_golite062009 |
| DNA binding | 0.701080369693496 | bayes_pls_golite062009 |
| catalytic activity | 0.24846317916908 | bayes_pls_golite062009 |
| sequence-specific DNA binding | 0.0698018163897043 | bayes_pls_golite062009 |
|
Region A: Residues: [452-539] |
1 11 21 31 41 51
| | | | | |
1 PDTKGQLEDF DSELIHLKQK LSESLDTRKE LWRKEQKLQT VLETLLSDVN QNQRNVNETM 60
61 SRSLANGIIN VKEITEKLKI SPESVFGT
|
|
Region B: Residues: [563-596] |
1 11 21 31 41 51
| | | | | |
1 FHIVVDTEET ATLIMNELYR MKGGRVTFIP LNRL
|
| Detection Method: | |
| Confidence: | 91.154902 |
| Match: | 1gxlA_ |
| Description: | Smc hinge domain |
Matching Structure (courtesy of the PDB): |
|
|
Region A: Residues: [540-562] |
1 11 21 31 41 51
| | | | | |
1 LGELIKVNDK YKTCAEVIGG NSL
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|
Region B: Residues: [597-600] |
1 11 21 31 41 51
| | | | | |
1 SLDS
|
|
Region C: Residues: [618-636] |
1 11 21 31 41 51
| | | | | |
1 IKKIKYEPRF EKAVKHVFG
|
| Detection Method: | |
| Confidence: | 91.154902 |
| Match: | 1gxlA_ |
| Description: | Smc hinge domain |
| Matching Structure (courtesy of the PDB): |
|
|
Region A: Residues: [601-617] |
1 11 21 31 41 51
| | | | | |
1 DVKFPSNTTT QIQFTPL
|
|
Region B: Residues: [637-663] |
1 11 21 31 41 51
| | | | | |
1 KTIVVKDLGQ GLKLAKKHKL NAITLDG
|
| Detection Method: | |
| Confidence: | 91.154902 |
| Match: | 1gxlA_ |
| Description: | Smc hinge domain |
| Matching Structure (courtesy of the PDB): |
|
|
Region A: Residues: [664-730] |
1 11 21 31 41 51
| | | | | |
1 DRADKRGVLT GGYLDQHKRT RLESLKNLNE SRSQHKKILE ELDFVRNELN DIDTKIDQVN 60
61 GNIRKVS
|
| Detection Method: | |
| Confidence: | 9.045757 |
| Match: | 1c1gA_ |
| Description: | Tropomyosin |
Matching Structure (courtesy of the PDB): |
|
|
Region A: Residues: [731-992] |
1 11 21 31 41 51
| | | | | |
1 NDRESVLTNI EVYRTSLNTK KNEKLILEES LNAIILKLEK LNTNRTFAQE KLNTFENDLL 60
61 QEFDSELSKE EKERLESLTK EISAAHNKLN ITSDALEGIT TTIDSLNAEL ESKLIPQEND 120
121 LESKMSEVGD AFIFGLQDEL KELQLEKESV EKQHENAVLE LGTVQREIES LIAEETNNKK 180
181 LLEKANNQQR LLLKKLDNFQ KSVEKTMIKK TTLVTRREEL QQRIREIGLL PEDALVNDFS 240
241 DITSDQLLQR LNDMNTEISG LK
|
| Detection Method: | |
| Confidence: | 9.045757 |
| Match: | 1c1gA_ |
| Description: | Tropomyosin |
| Matching Structure (courtesy of the PDB): |
|
|
Region A: Residues: [993-1045] |
1 11 21 31 41 51
| | | | | |
1 NVNKRAFENF KKFNERRKDL AERASELDES KDSIQDLIVK LKQQKVNAVD STF
|
| Detection Method: | |
Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.
Found no confident structure predictions for this domain.
|
Region A: Residues: [1046-1230] |
1 11 21 31 41 51
| | | | | |
1 QKVSENFEAV FERLVPRGTA KLIIHRKNDN ANDHDESIDV DMDAESNESQ NGKDSEIMYT 60
61 GVSISVSFNS KQNEQLHVEQ LSGGQKTVCA IALILAIQMV DPASFYLFDE IDAALDKQYR 120
121 TAVATLLKEL SKNAQFICTT FRTDMLQVAD KFFRVKYENK ISTVIEVNRE EAIGFIRGSN 180
181 KFAEV
|
| Detection Method: | |
| Confidence: | 144.94696 |
| Match: | 1e69A_ |
| Description: | Smc head domain |
Matching Structure (courtesy of the PDB): |
|
