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View Structure Prediction Details

Protein: SWC4
Organism: Saccharomyces cerevisiae
Length: 476 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for SWC4.

Description E-value Query
Range		 Subject
Range
SWC4_YEAST - SWR1-complex protein 4 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=SWC4 PE=1 SV=1
SWC4 - Component of the Swr1p complex that incorporates Htz1p into chromatin; component of the NuA4 histone...
 0.0 [1..476] [1..476]
gi|19114480 - gi|19114480|ref|NP_593568.1| hypothetical protein SPAC9G1.13c [Schizosaccharomyces pombe 972h-]
SPAC9G1.13c - histone acetyltransferase complex subunit Swc4
 0.0 [1..467] [1..381]
gi|7243231 - gi|7243231|dbj|BAA92663.1| KIAA1425 protein [Homo sapiens]
 2.0E-98 [2..298] [31..314]
DMAP1_MOUSE - DNA methyltransferase 1-associated protein 1 OS=Mus musculus GN=Dmap1 PE=1 SV=1
 7.0E-95 [2..298] [3..286]
ekl-4 - status:Confirmed UniProt:Q8WQA7 protein_id:CAD21666.1
 1.0E-81 [6..283] [2..253]
SWC4_ARATH - SWR1-complex protein 4 OS=Arabidopsis thaliana GN=SWC4 PE=1 SV=1
 2.0E-68 [1..278] [1..248]

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Predicted Domain #1
Region A:
Residues: [1-160] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSSSDIFDVL NIKQKSRSPT NGQVSVPSSS AANRPKPQVT GMQRELFNLL GENQPPVVIK  60
   61 SGNNFKEKML STSKPSPWSF VEFKANNSVT LRHWVKGSKE LIGDTPKESP YSKFNQHLSI 120
  121 PSFTKEEYEA FMNENEGTQK SVESEKNHNE NFTNEKKDES

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [161-221] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KNSWSFEEIE YLFNLCKKYD LRWFLIFDRY SYNNSRTLED LKEKFYYTCR NYFKASDPSN  60
   61 P

[Run NCBI BLAST on this sequence.]

Detection Method: Pfam
Confidence: 3.568636
Match: PF00249
Description: Myb-like DNA-binding domain

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted functions:

Term Confidence Notes
histone acetyltransferase activity 5.78270240334849 bayes_pls_golite062009
lysine N-acetyltransferase activity 5.78270240334849 bayes_pls_golite062009
N-acyltransferase activity 4.53404381270892 bayes_pls_golite062009
N-acetyltransferase activity 4.38345537045529 bayes_pls_golite062009
acetyltransferase activity 3.81897719505269 bayes_pls_golite062009
acyltransferase activity 3.35931919126926 bayes_pls_golite062009
transferase activity, transferring acyl groups other than amino-acyl groups 3.31384699789032 bayes_pls_golite062009
transferase activity, transferring acyl groups 3.09869056563841 bayes_pls_golite062009
transcription regulator activity 3.05971315776284 bayes_pls_golite062009
DNA binding 2.98143466641891 bayes_pls_golite062009
nucleic acid binding 2.85666780317594 bayes_pls_golite062009
binding 2.77786931095369 bayes_pls_golite062009
transcription factor activity 2.3234819540139 bayes_pls_golite062009
general RNA polymerase II transcription factor activity 1.5871271401402 bayes_pls_golite062009
chromatin binding 1.46306211220814 bayes_pls_golite062009
sequence-specific DNA binding 1.23729321119532 bayes_pls_golite062009
protein deacetylase activity 1.23476914879396 bayes_pls_golite062009
histone deacetylase activity 1.18710646783152 bayes_pls_golite062009
RNA polymerase II transcription factor activity 1.02200659886159 bayes_pls_golite062009
protein binding 1.00288283679871 bayes_pls_golite062009
transcription repressor activity 0.700409976805769 bayes_pls_golite062009
DNA-dependent ATPase activity 0.658518317984762 bayes_pls_golite062009
transcription activator activity 0.58607600202198 bayes_pls_golite062009
structure-specific DNA binding 0.559482273209868 bayes_pls_golite062009
deacetylase activity 0.534082291544628 bayes_pls_golite062009
histone binding 0.489784140732052 bayes_pls_golite062009
transcription factor binding 0.270053518126008 bayes_pls_golite062009
cytoskeletal protein binding 0.244471307852075 bayes_pls_golite062009
telomeric DNA binding 0.233668696331578 bayes_pls_golite062009
DNA helicase activity 0.192832786095412 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 0.151335943405565 bayes_pls_golite062009
double-stranded DNA binding 0.0110175210304684 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [222-476] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LLSSLNFSAE KEIERKKYLQ RLLSRSAAEI AEEEALVVES KKFEMAAKRT LAERESLLRL  60
   61 LDSPHSDQTI TQYLTSQGMS QLYNALLADK TRKRKHDLNI PENPWMKQQQ QFAQHRQLQQ 120
  121 LNVKKSEVKE NLSPKKTKRQ RQEMQTALKR KSESAYAEQL LKDFNSDERK ALGVITHGEK 180
  181 LSPGVYLRST KLSTFKPALQ NKILAILQEL SLPSRPVMPS FDVMERQEEL LKKINTLIDL 240
  241 KKHVDKYEAG MSITK

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

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Created and Maintained by: Michael Riffle