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View Structure Prediction Details

Protein: OTU1
Organism: Saccharomyces cerevisiae
Length: 301 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for OTU1.

Description E-value Query
Range
Subject
Range
OTU1_YEAST - Ubiquitin thioesterase OTU1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=OTU1 PE=1 SV...
OTU1 - Deubiquitylation enzyme that binds to the chaperone-ATPase Cdc48p; may contribute to regulation of p...
1.0E-98 [1..301] [1..301]
otu1 - ubiquitin-specific protease
OTU1_SCHPO - Putative ubiquitin thioesterase otu1 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=otu1 ...
4.0E-80 [1..299] [4..328]
FBpp0304189, CG4... - This gene is referred to in FlyBase by the symbol Dmel\CG4603 (CG4603, FBgn0035593). It is a protein...
4.0E-72 [5..299] [1..346]
gi|9454545, gi|1... - gi|9454545|gb|AAF87868.1|AC012561_1 Unknown protein [Arabidopsis thaliana], gi|28393989|gb|AAO42402....
4.0E-55 [106..299] [2..206]
OTUD5_MOUSE - OTU domain-containing protein 5 OS=Mus musculus GN=Otud5 PE=1 SV=2
1.0E-43 [66..239] [167..345]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
1.0E-42 [52..239] [5..206]
OTUD5 - OTU domain containing 5
7.0E-42 [52..239] [144..350]

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Predicted Domain #1
Region A:
Residues: [1-94]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKLKVTGAGI NQVVTLKQDA TLNDLIEHIN VDVKTMRFGY PPQRINLQGE DASLGQTQLD  60
   61 ELGINSGEKI TIESSDSNES FSLPPPQPKP KRVL

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score
SCOP
Match
SCOP Description
View Download 0.500 d.15.1 Ubiquitin-like
View Download 0.615 b.52.2 ADC-like
View Download 0.540 d.94.1 HPr-like
View Download 0.642 c.97.1 Cytidine deaminase-like
View Download 0.477 b.44.1 EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain
View Download 0.474 b.24.1 Hyaluronate lyase-like, C-terminal domain
View Download 0.440 b.3.2 Carboxypeptidase D, a regulatory domain
View Download 0.430 d.15.1 Ubiquitin-like
View Download 0.427 b.1.2 Fibronectin type III
View Download 0.419 c.13.2 Anti-sigma factor antagonist SpoIIaa
View Download 0.418 d.109.1 Actin depolymerizing proteins
View Download 0.409 b.1.20 Tp47 lipoprotein, middle and C-terminal domains
View Download 0.406 b.40.4 Nucleic acid-binding proteins
View Download 0.394 b.1.2 Fibronectin type III
View Download 0.392 d.94.1 HPr-like
View Download 0.374 b.7.3 PHL pollen allergen
View Download 0.374 b.1.18 E set domains
View Download 0.369 d.109.1 Actin depolymerizing proteins
View Download 0.369 b.13.3 Description not found.
View Download 0.367 d.15.1 Ubiquitin-like
View Download 0.360 d.15.1 Ubiquitin-like
View Download 0.346 c.15.1 BRCT domain
View Download 0.345 c.47.1 Thioredoxin-like
View Download 0.340 b.1.1 Immunoglobulin
View Download 0.338 b.1.18 E set domains
View Download 0.331 d.94.1 HPr-like
View Download 0.327 d.15.4 2Fe-2S ferredoxin-like
View Download 0.314 a.74.1 Cyclin-like
View Download 0.314 c.47.1 Thioredoxin-like
View Download 0.311 b.52.2 ADC-like
View Download 0.311 d.15.2 CAD & PB1 domains
View Download 0.305 b.114.1 N-utilization substance G protein NusG, insert domain
View Download 0.303 d.15.1 Ubiquitin-like
View Download 0.275 b.11.1 gamma-Crystallin-like
View Download 0.257 b.1.1 Immunoglobulin
View Download 0.256 b.49.1 N-terminal domain of alpha and beta subunits of F1 ATP synthase
View Download 0.256 b.44.1 EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain
View Download 0.248 d.74.5 Hypothetical protein Yml108w
View Download 0.245 d.15.1 Ubiquitin-like
View Download 0.243 g.7.1 Snake toxin-like
View Download 0.243 b.52.2 ADC-like
View Download 0.242 d.131.1 DNA clamp
View Download 0.233 b.40.2 Bacterial enterotoxins
View Download 0.232 a.60.9 lambda integrase-like, N-terminal domain
View Download 0.223 b.7.4 Rab geranylgeranyltransferase alpha-subunit, insert domain
View Download 0.216 d.68.3 SirA-like
View Download 0.213 d.76.1 GYF domain
View Download 0.203 c.53.1 Resolvase-like
View Download 0.200 d.15.6 Superantigen toxins, C-terminal domain

Predicted functions:

Term Confidence Notes
cysteine-type peptidase activity 6.54685807643041 bayes_pls_golite062009
small conjugating protein-specific protease activity 6.39247995905454 bayes_pls_golite062009
ubiquitin-specific protease activity 5.91394445088241 bayes_pls_golite062009
ubiquitin thiolesterase activity 4.1832081096766 bayes_pls_golite062009
peptidase activity 3.28868056127375 bayes_pls_golite062009
peptidase activity, acting on L-amino acid peptides 3.01472402774099 bayes_pls_golite062009
thiolester hydrolase activity 2.96735553959103 bayes_pls_golite062009
SUMO-specific protease activity 2.65263825059319 bayes_pls_golite062009
hydrolase activity 2.29464693834116 bayes_pls_golite062009
endopeptidase activity 2.26699762664334 bayes_pls_golite062009
transcription regulator activity 2.13534310479552 bayes_pls_golite062009
cysteine-type endopeptidase activity 1.95802900199539 bayes_pls_golite062009
DNA binding 1.95013248594294 bayes_pls_golite062009
binding 1.92046698500094 bayes_pls_golite062009
nucleic acid binding 1.74961503597682 bayes_pls_golite062009
transcription factor activity 1.20242512567523 bayes_pls_golite062009
catalytic activity 1.05972260874031 bayes_pls_golite062009
protein binding 0.874003454509364 bayes_pls_golite062009
NEDD8-specific protease activity 0.687958315289315 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 0.467924587720185 bayes_pls_golite062009
calcium-dependent cysteine-type endopeptidase activity 0.196538841514154 bayes_pls_golite062009
transferase activity 0.0852393573521809 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [95-232]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KSTEMSIGGS GENVLSVHPV LDDNSCLFHA IAYGIFKQDS VRDLREMVSK EVLNNPVKFN  60
   61 DAILDKPNKD YAQWILKMES WGGAIEIGII SDALAVAIYV VDIDAVKIEK FNEDKFDNYI 120
  121 LILFNGIHYD SLTMNEFK

[Run NCBI BLAST on this sequence.]

Detection Method: Pfam
Confidence: 38.79588
Match: PF02338
Description: OTU-like cysteine protease

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted functions:

Term Confidence Notes
transcription regulator activity 4.47951889934838 bayes_pls_golite062009
DNA binding 4.31051339571017 bayes_pls_golite062009
nucleic acid binding 4.04689255235626 bayes_pls_golite062009
transcription factor activity 3.28758716579796 bayes_pls_golite062009
binding 2.99742524370422 bayes_pls_golite062009
RNA polymerase II transcription factor activity 2.05542379535543 bayes_pls_golite062009
transcription activator activity 1.97757778483124 bayes_pls_golite062009
transcription repressor activity 1.44763794968807 bayes_pls_golite062009
sequence-specific DNA binding 1.26862497534835 bayes_pls_golite062009
transcription factor binding 1.23738346570539 bayes_pls_golite062009
chromatin binding 1.10179307236186 bayes_pls_golite062009
protein binding 0.952480850696098 bayes_pls_golite062009
specific RNA polymerase II transcription factor activity 0.776754909146767 bayes_pls_golite062009
transcription cofactor activity 0.627794176881836 bayes_pls_golite062009
catalytic activity 0.263007611601737 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [233-301]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TVFNKNQPES DDVLTAALQL ASNLKQTGYS FNTHKAQIKC NTCQMTFVGE REVARHAEST  60
   61 GHVDFGQNR

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score
SCOP
Match
SCOP Description
View Download 0.422 a.6.1 Putative DNA-binding domain
View Download 0.478 d.58.17 Metal-binding domain
View Download 0.449 d.58.3 Protease propeptides/inhibitors
View Download 0.462 d.48.1 RecA protein, C-terminal domain
View Download 0.476 d.58.17 Metal-binding domain
View Download 0.420 d.48.1 RecA protein, C-terminal domain
View Download 0.416 a.6.1 Putative DNA-binding domain
View Download 0.411 a.6.1 Putative DNA-binding domain
View Download 0.396 a.6.1 Putative DNA-binding domain
View Download 0.380 a.6.1 Putative DNA-binding domain
View Download 0.362 a.60.11 Hypothetical protein YjbJ
View Download 0.354 c.47.1 Thioredoxin-like
View Download 0.346 a.44.1 Disulphide-bond formation facilitator (DSBA), insertion domain
View Download 0.336 d.48.1 RecA protein, C-terminal domain
View Download 0.335 d.58.17 Metal-binding domain
View Download 0.330 d.15.2 CAD & PB1 domains
View Download 0.317 a.44.1 Disulphide-bond formation facilitator (DSBA), insertion domain
View Download 0.312 a.6.1 Putative DNA-binding domain
View Download 0.309 a.4.5 "Winged helix" DNA-binding domain
View Download 0.301 a.4.1 Homeodomain-like
View Download 0.300 a.4.1 Homeodomain-like
View Download 0.296 d.59.1 Ribosomal protein L30p/L7e
View Download 0.295 g.28.1 Thyroglobulin type-1 domain
View Download 0.295 a.35.1 lambda repressor-like DNA-binding domains
View Download 0.290 g.28.1 Thyroglobulin type-1 domain
View Download 0.289 a.6.1 Putative DNA-binding domain
View Download 0.288 d.93.1 SH2 domain
View Download 0.287 d.48.1 RecA protein, C-terminal domain
View Download 0.286 a.44.1 Disulphide-bond formation facilitator (DSBA), insertion domain
View Download 0.282 a.4.5 "Winged helix" DNA-binding domain
View Download 0.271 a.6.1 Putative DNA-binding domain
View Download 0.264 d.48.1 RecA protein, C-terminal domain
View Download 0.264 c.47.1 Thioredoxin-like
View Download 0.262 a.6.1 Putative DNA-binding domain
View Download 0.261 a.6.1 Putative DNA-binding domain
View Download 0.261 a.44.1 Disulphide-bond formation facilitator (DSBA), insertion domain
View Download 0.261 a.44.1 Disulphide-bond formation facilitator (DSBA), insertion domain
View Download 0.260 d.48.1 RecA protein, C-terminal domain
View Download 0.260 d.48.1 RecA protein, C-terminal domain
View Download 0.257 d.15.2 CAD & PB1 domains
View Download 0.254 c.30.1 PreATP-grasp domain
View Download 0.253 d.48.1 RecA protein, C-terminal domain
View Download 0.249 a.6.1 Putative DNA-binding domain
View Download 0.247 a.8.3 Families 57/38 glycoside transferase middle domain
View Download 0.245 a.44.1 Disulphide-bond formation facilitator (DSBA), insertion domain
View Download 0.243 d.48.1 RecA protein, C-terminal domain
View Download 0.242 d.15.2 CAD & PB1 domains
View Download 0.242 d.15.2 CAD & PB1 domains
View Download 0.240 a.6.1 Putative DNA-binding domain
View Download 0.233 d.48.1 RecA protein, C-terminal domain
View Download 0.231 d.48.1 RecA protein, C-terminal domain
View Download 0.230 d.48.1 RecA protein, C-terminal domain
View Download 0.228 d.48.1 RecA protein, C-terminal domain
View Download 0.220 d.58.36 Sulfite reductase, domains 1 and 3
View Download 0.217 d.48.1 RecA protein, C-terminal domain
View Download 0.214 i.1.1 Ribosome and ribosomal fragments
View Download 0.210 d.58.48 MTH1187-like
View Download 0.207 c.47.1 Thioredoxin-like
View Download 0.207 d.48.1 RecA protein, C-terminal domain
View Download 0.201 a.144.2 Ribosomal protein L20
View Download 0.200 a.144.2 Ribosomal protein L20


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle