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View Structure Prediction Details

Protein: BRR2
Organism: Saccharomyces cerevisiae
Length: 2163 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for BRR2.

Description E-value Query
Range		 Subject
Range
CE21971 - status:Partially_confirmed UniProt:Q9U2G0 protein_id:CAB60351.1
 0.0 [8..2163] [3..2129]
gi|14043179 - gi|14043179|gb|AAH07577.1| SNRNP200 protein [Homo sapiens]
 0.0 [848..2163] [1..1299]
MUG81_SCHPO - Putative helicase mug81 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=mug81 PE=1 SV=1
mug81 - ATP-dependent RNA helicase Slh1
 0.0 [279..2149] [63..1923]
DEXHD_ARATH - DExH-box ATP-dependent RNA helicase DExH13 OS=Arabidopsis thaliana GN=At2g42270 PE=2 SV=1
 0.0 [8..2163] [10..2162]
SLH1 - Putative RNA helicase related to Ski2p, involved in translation inhibition of non-poly(A) mRNAs; req...
 0.0 [230..2116] [16..1919]

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Predicted Domain #1
Region A:
Residues: [1-131] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTEHETKDKA KKIREIYRYD EMSNKVLKVD KRFMNTSQNP QRDAEISQPK SMSGRISAKD  60
   61 MGQGLCNNIN KGLKENDVAV EKTGKSASLK KIQQHNTILN SSSDFRLHYY PKDPSNVETY 120
  121 EQILQWVTEV L

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [132-211] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GNDIPHDLII GTADIFIRQL KENEENEDGN IEERKEKIQH ELGINIDSLK FNELVKLMKN  60
   61 ITDYETHPDN SNKQAVAILA

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

    MCM
Score		 GO
Score		 GO
Term		 SCOP
Match		 SCOP Description
View Download 0.831 0.017 pre-mRNA splicing factor activity a.64.1 Saposin

Predicted Domain #3
Region A:
Residues: [212-464] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DDEKSDEEEV TEMSNNANVL GGEINDNEDD DEEYDYNDVE VNSKKKNKRA LPNIENDIIK  60
   61 LSDSKTSNIE SVPIYSIDEF FLQRKLRSEL GYKDTSVIQD LSEKILNDIE TLEHNPVALE 120
  121 QKLVDLLKFE NISLAEFILK NRSTIFWGIR LAKSTENEIP NLIEKMVAKG LNDLVEQYKF 180
  181 RETTHSKREL DSGDDQPQSS EAKRTKFSNP AIPPVIDLEK IKFDESSKLM TVTKVSLPEG 240
  241 SFKRVKPQYD EIH

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [465-698] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 IPAPSKPVID YELKEITSLP DWCQEAFPSS ETTSLNPIQS KVFHAAFEGD SNMLICAPTG  60
   61 SGKTNIALLT VLKALSHHYN PKTKKLNLSA FKIVYIAPLK ALVQEQVREF QRRLAFLGIK 120
  121 VAELTGDSRL SRKQIDETQV LVSTPEKWDI TTRNSNNLAI VELVRLLIID EIHLLHDDRG 180
  181 PVLESIVART FWASKYGQEY PRIIGLSATL PNYEDVGRFL RVPKEGLFYF DSSF

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 86.69897
Match: 1hv8A_
Description: Putative DEAD box RNA helicase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
4.704140727858 bayes_pls_golite062009
structural constituent of ribosome 3.070470376968 bayes_pls_golite062009
binding 2.64537357529343 bayes_pls_golite062009
nucleic acid binding 2.51683451033161 bayes_pls_golite062009
RNA binding 2.29590582680214 bayes_pls_golite062009
structural molecule activity 2.08211451183607 bayes_pls_golite062009
DNA binding 1.94055378599526 bayes_pls_golite062009
transcription regulator activity 1.83584389083042 bayes_pls_golite062009
RNA helicase activity 1.42791449104435 bayes_pls_golite062009
RNA-dependent ATPase activity 1.39335733374328 bayes_pls_golite062009
ATP-dependent RNA helicase activity 1.36724390116598 bayes_pls_golite062009
snRNA binding 1.20045983086701 bayes_pls_golite062009
catalytic activity 1.00104173493322 bayes_pls_golite062009
transcription factor activity 0.959949409533517 bayes_pls_golite062009
mRNA binding 0.76699944561918 bayes_pls_golite062009
helicase activity 0.6191010101321 bayes_pls_golite062009
purine nucleotide binding 0.569910969126728 bayes_pls_golite062009
purine ribonucleotide binding 0.568840867400671 bayes_pls_golite062009
ribonucleotide binding 0.568779924702229 bayes_pls_golite062009
nucleotide binding 0.564275755355315 bayes_pls_golite062009
general RNA polymerase II transcription factor activity 0.312659433116074 bayes_pls_golite062009
purine NTP-dependent helicase activity 0.29664013896754 bayes_pls_golite062009
ATP-dependent helicase activity 0.29664013896754 bayes_pls_golite062009
translation regulator activity 0.29096092258568 bayes_pls_golite062009
translation factor activity, nucleic acid binding 0.274994961137851 bayes_pls_golite062009
ATP binding 0.1860481660648 bayes_pls_golite062009
protein binding 0.170837278876362 bayes_pls_golite062009
adenyl ribonucleotide binding 0.152859582615242 bayes_pls_golite062009
adenyl nucleotide binding 0.138615225841109 bayes_pls_golite062009
nucleoside-triphosphatase activity 0.0530667986761242 bayes_pls_golite062009
pyrophosphatase activity 0.0482442222493492 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides 0.028470639373934 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 0.0265151533232588 bayes_pls_golite062009

Predicted Domain #5
Region A:
Residues: [699-903] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RPCPLSQQFC GIKERNSLKK LKAMNDACYE KVLESINEGN QIIVFVHSRK ETSRTATWLK  60
   61 NKFAEENITH KLTKNDAGSK QILKTEAANV LDPSLRKLIE SGIGTHHAGL TRSDRSLSED 120
  121 LFADGLLQVL VCTATLAWGV NLPAHTVIIK GTDVYSPEKG SWEQLSPQDV LQMLGRAGRP 180
  181 RYDTFGEGII ITDQSNVQYY LSVLN

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 86.69897
Match: 1hv8A_
Description: Putative DEAD box RNA helicase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
structural molecule activity 2.81579918518889 bayes_pls_golite062009
binding 2.59063189683655 bayes_pls_golite062009
protein binding 1.40069187357924 bayes_pls_golite062009
cation channel activity 0.484734651147527 bayes_pls_golite062009
cytoskeletal protein binding 0.448241458604601 bayes_pls_golite062009
ligand-gated ion channel activity 0.445394181993741 bayes_pls_golite062009
ligand-gated channel activity 0.445394181993741 bayes_pls_golite062009
gated channel activity 0.437275980569276 bayes_pls_golite062009
ion channel activity 0.351655405987795 bayes_pls_golite062009
actin binding 0.328787215513486 bayes_pls_golite062009
substrate-specific channel activity 0.21875054393881 bayes_pls_golite062009
channel activity 0.196534845734361 bayes_pls_golite062009
passive transmembrane transporter activity 0.196534845734361 bayes_pls_golite062009

Predicted Domain #6
Region A:
Residues: [904-1037] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QQLPIESQFV SKLVDNLNAE VVAGNIKCRN DAVNWLAYTY LYVRMLASPM LYKVPDISSD  60
   61 GQLKKFRESL VHSALCILKE QELVLYDAEN DVIEATDLGN IASSFYINHA SMDVYNRELD 120
  121 EHTTQIDLFR IFSM

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 5.69897
Match: 1d9xA_
Description: Nucleotide excision repair enzyme UvrB
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
4.704140727858 bayes_pls_golite062009
structural constituent of ribosome 3.070470376968 bayes_pls_golite062009
binding 2.64537357529343 bayes_pls_golite062009
nucleic acid binding 2.51683451033161 bayes_pls_golite062009
RNA binding 2.29590582680214 bayes_pls_golite062009
structural molecule activity 2.08211451183607 bayes_pls_golite062009
DNA binding 1.94055378599526 bayes_pls_golite062009
transcription regulator activity 1.83584389083042 bayes_pls_golite062009
RNA helicase activity 1.42791449104435 bayes_pls_golite062009
RNA-dependent ATPase activity 1.39335733374328 bayes_pls_golite062009
ATP-dependent RNA helicase activity 1.36724390116598 bayes_pls_golite062009
snRNA binding 1.20045983086701 bayes_pls_golite062009
catalytic activity 1.00104173493322 bayes_pls_golite062009
transcription factor activity 0.959949409533517 bayes_pls_golite062009
mRNA binding 0.76699944561918 bayes_pls_golite062009
helicase activity 0.6191010101321 bayes_pls_golite062009
purine nucleotide binding 0.569910969126728 bayes_pls_golite062009
purine ribonucleotide binding 0.568840867400671 bayes_pls_golite062009
ribonucleotide binding 0.568779924702229 bayes_pls_golite062009
nucleotide binding 0.564275755355315 bayes_pls_golite062009
general RNA polymerase II transcription factor activity 0.312659433116074 bayes_pls_golite062009
purine NTP-dependent helicase activity 0.29664013896754 bayes_pls_golite062009
ATP-dependent helicase activity 0.29664013896754 bayes_pls_golite062009
translation regulator activity 0.29096092258568 bayes_pls_golite062009
translation factor activity, nucleic acid binding 0.274994961137851 bayes_pls_golite062009
ATP binding 0.1860481660648 bayes_pls_golite062009
protein binding 0.170837278876362 bayes_pls_golite062009
adenyl ribonucleotide binding 0.152859582615242 bayes_pls_golite062009
adenyl nucleotide binding 0.138615225841109 bayes_pls_golite062009
nucleoside-triphosphatase activity 0.0530667986761242 bayes_pls_golite062009
pyrophosphatase activity 0.0482442222493492 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides 0.028470639373934 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 0.0265151533232588 bayes_pls_golite062009

Predicted Domain #7
Region A:
Residues: [1038-1318] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SEEFKYVSVR YEEKRELKQL LEKAPIPIRE DIDDPLAKVN VLLQSYFSQL KFEGFALNSD  60
   61 IVFIHQNAGR LLRAMFEICL KRGWGHPTRM LLNLCKSATT KMWPTNCPLR QFKTCPVEVI 120
  121 KRLEASTVPW GDYLQLETPA EVGRAIRSEK YGKQVYDLLK RFPKMSVTCN AQPITRSVMR 180
  181 FNIEIIADWI WDMNVHGSLE PFLLMLEDTD GDSILYYDVL FITPDIVGHE FTLSFTYELK 240
  241 QHNQNNLPPN FFLTLISENW WHSEFEIPVS FNGFKLPKKF P

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #8
Region A:
Residues: [1319-1784] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PPTPLLENIS ISTSELGNDD FSEVFEFKTF NKIQSQVFES LYNSNDSVFV GSGKGTGKTA  60
   61 MAELALLNHW RQNKGRAVYI NPSGEKIDFL LSDWNKRFSH LAGGKIINKL GNDPSLNLKL 120
  121 LAKSHVLLAT PVQFELLSRR WRQRKNIQSL ELMIYDDAHE ISQGVYGAVY ETLISRMIFI 180
  181 ATQLEKKIRF VCLSNCLANA RDFGEWAGMT KSNIYNFSPS ERIEPLEINI QSFKDVEHIS 240
  241 FNFSMLQMAF EASAAAAGNR NSSSVFLPSR KDCMEVASAF MKFSKAIEWD MLNVEEEQIV 300
  301 PYIEKLTDGH LRAPLKHGVG ILYKGMASND ERIVKRLYEY GAVSVLLISK DCSAFACKTD 360
  361 EVIILGTNLY DGAEHKYMPY TINELLEMVG LASGNDSMAG KVLILTSHNM KAYYKKFLIE 420
  421 PLPTESYLQY IIHDTLNNEI ANSIIQSKQD CVDWFTYSYF YRRIHV

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted functions:

Term Confidence Notes
6.55929165712784 bayes_pls_golite062009
RNA-dependent ATPase activity 3.40791872038512 bayes_pls_golite062009
ATP-dependent RNA helicase activity 3.40070584403887 bayes_pls_golite062009
RNA helicase activity 3.25446655280881 bayes_pls_golite062009
structural molecule activity 2.80935217964088 bayes_pls_golite062009
binding 2.65544526722793 bayes_pls_golite062009
nucleic acid binding 2.30172682093249 bayes_pls_golite062009
helicase activity 1.87693598354249 bayes_pls_golite062009
purine NTP-dependent helicase activity 1.87127651162653 bayes_pls_golite062009
ATP-dependent helicase activity 1.87127651162653 bayes_pls_golite062009
protein binding 1.50286160643298 bayes_pls_golite062009
ligand-gated ion channel activity 0.85500903576568 bayes_pls_golite062009
ligand-gated channel activity 0.85500903576568 bayes_pls_golite062009
cation channel activity 0.84907542359093 bayes_pls_golite062009
gated channel activity 0.79614932073028 bayes_pls_golite062009
ion channel activity 0.69968450497191 bayes_pls_golite062009
cytoskeletal protein binding 0.60798225319459 bayes_pls_golite062009
substrate-specific channel activity 0.554024107811049 bayes_pls_golite062009
actin binding 0.54002000529721 bayes_pls_golite062009
channel activity 0.52698001588063 bayes_pls_golite062009
passive transmembrane transporter activity 0.52698001588063 bayes_pls_golite062009
voltage-gated cation channel activity 0.410543003164924 bayes_pls_golite062009
voltage-gated channel activity 0.272496099348536 bayes_pls_golite062009
voltage-gated ion channel activity 0.236012840738827 bayes_pls_golite062009

Predicted Domain #9
Region A:
Residues: [1785-1920] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NPSYYGVRDT SPHGISVFLS NLVETCLNDL VESSFIEIDD TEAEVTAEVN GGDDEATEII  60
   61 STLSNGLIAS HYGVSFFTIQ SFVSSLSNTS TLKNMLYVLS TAVEFESVPL RKGDRALLVK 120
  121 LSKRLPLRFP EHTSSG

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #10
Region A:
Residues: [1921-2087] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SVSFKVFLLL QAYFSRLELP VDFQNDLKDI LEKVVPLINV VVDILSANGY LNATTAMDLA  60
   61 QMLIQGVWDV DNPLRQIPHF NNKILEKCKE INVETVYDIM ALEDEERDEI LTLTDSQLAQ 120
  121 VAAFVNNYPN VELTYSLNNS DSLISGVKQK ITIQLTRDVE PENLQVT

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 3.154902
Match: 1jj2X_
Description: Ribosomal protein L32e
Matching Structure (courtesy of the PDB):

Predicted Domain #11
Region A:
Residues: [2088-2163] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SEKYPFDKLE SWWLVLGEVS KKELYAIKKV TLNKETQQYE LEFDTPTSGK HNLTIWCVCD  60
   61 SYLDADKELS FEINVK

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

    MCM
Score		 GO
Score		 GO
Term		 SCOP
Match		 SCOP Description
View Download 0.766 0.987 pre-mRNA splicing factor activity b.38.1 Sm-like ribonucleoproteins

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle