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View Structure Prediction Details

Protein: Ptp10D-PB
Organism: Drosophila melanogaster
Length: 1631 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for Ptp10D-PB.

Description E-value Query
Range		 Subject
Range
Ptp10D-PA, Ptp10D-PD - The gene Protein tyrosine phosphatase 10D is referred to in FlyBase by the symbol Dmel\Ptp10D (CG181...
 1096.0 [0..1] [1625..1]

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Predicted Domain #1
Region A:
Residues: [1-106] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLYQLSKATT RIRLKRQKAV PQHRWLWSLA FLAAFTLKDV RCADLAISIP NNPGLDDGAS  60
   61 YRLDYSPPFG YPEPNTTIAS REIGDEIQFS RALPGTKYNF WLYYTN

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 44.69897
Match: 2v5yA
Description: No description for 2v5yA was found.

Predicted Domain #2
Region A:
Residues: [107-134] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 FTHHDWLTWT VTITTAPDPP SNLSVQVR

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 17.69897
Match: 1zlgA
Description: No description for 1zlgA was found.

Predicted Domain #3
Region A:
Residues: [135-771] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SGKNAIILWS PPTQGSYTAF KIKVLGLSEA SSSYNRTFQV NDNTFQHSVK ELTPGATYQV  60
   61 QAYTIYDGKE SVAYTSRNFT TKPNTPGKFI VWFRNETTLL VLWQPPYPAG IYTHYKVSIE 120
  121 PPDANDSVLY VEKEGEPPGP AQAAFKGLVP GRAYNISVQT MSEDEISLPT TAQYRTVPLR 180
  181 PLNVTFDRDF ITSNSFRVLW EAPKGISEFD KYQVSVATTR RQSTVPRSNE PVAFFDFRDI 240
  241 AEPGKTFNVI VKTVSGKVTS WPATGDVTLR PLPVRNLRSI NDDKTNTMII TWEADPASTQ 300
  301 DEYRIVYHEL ETFNGDTSTL TTDRTRFTLE SLLPGRNYSL SVQAVSKKME SNETSIFVVT 360
  361 RPSSPIIEDL KSIRMGLNIS WKSDVNSKQE QYEVLYSRNG TSDLRTQKTK ESRLVIKNLQ 420
  421 PGAGYELKVF AVSHDLRSEP HAYFQAVYPN PPRNMTIETV RSNSVLVHWS PPESGEFTEY 480
  481 SIRYRTDSEQ QWVRLPSVRS TEADITDMTK GEKYTIQVNT VSFGVESPVP QEVNTTVPPN 540
  541 PVSNIIQLVD SRNITLEWPK PEGRVESYIL KWWPSDNPGR VQTKNVSENK SADDLSTVRV 600
  601 LIGELMPGVQ YKFDIQTTSY GILSGITSLY PRTMPLI

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 19.522879
Match: 1e07A
Description: Model of human carcinoembryonic antigen by homology modelling and curve-fitting to experimental solution scattering data
Matching Structure (courtesy of the PDB):

Predicted Domain #4
Region A:
Residues: [772-850] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QSDVVVANGE KEDERDTITL SYTPTPQSSS KFDIYRFSLG DAEIRDKEKL ANDTDRKVTF  60
   61 TGLVPGRLYN ITVWTVSGG

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 52.09691
Match: 1fnfA
Description: FRAGMENT OF HUMAN FIBRONECTIN ENCOMPASSING TYPE-III REPEATS 7 THROUGH 10
Matching Structure (courtesy of the PDB):

Predicted Domain #5
Region A:
Residues: [851-956] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VASLPIQRQD RLYPEPITQL HATNITDTEI SLRWDLPKGE YNDFDIAYLT ADNLLAQNMT  60
   61 TRNEITISDL RPHRNYTFTV VVRSGTESSV LRSSSPLSAS FTTNEA

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 38.0
Match: 1fnhA
Description: Fibronectin, different Fn3 modules
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transmembrane receptor activity 4.21125462030555 bayes_pls_golite062009
receptor activity 4.09185309744435 bayes_pls_golite062009
protein binding 3.24522318184038 bayes_pls_golite062009
molecular transducer activity 3.24090483126624 bayes_pls_golite062009
signal transducer activity 3.24090483126624 bayes_pls_golite062009
cytokine binding 3.21238178184503 bayes_pls_golite062009
growth factor binding 2.99437744892471 bayes_pls_golite062009
cytokine receptor activity 2.76876397305497 bayes_pls_golite062009
binding 2.69537882298808 bayes_pls_golite062009
cell adhesion molecule binding 2.32179186005318 bayes_pls_golite062009
axon guidance receptor activity 2.01367445237355 bayes_pls_golite062009
peptide hormone binding 1.9205359237864 bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor 1.61421027298524 bayes_pls_golite062009
protein kinase activity 1.60674218431738 bayes_pls_golite062009
kinase activity 1.57994485110649 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 1.44501485815273 bayes_pls_golite062009
receptor binding 1.31676259534833 bayes_pls_golite062009
hormone binding 1.31120662451488 bayes_pls_golite062009
interleukin-6 receptor activity 1.18385625326067 bayes_pls_golite062009
interleukin-6 binding 1.18385625326067 bayes_pls_golite062009
transferase activity 1.13635878582843 bayes_pls_golite062009
protein dimerization activity 0.86564366658585 bayes_pls_golite062009
nucleic acid binding 0.745125737480015 bayes_pls_golite062009
transcription regulator activity 0.718355770608923 bayes_pls_golite062009
protein serine/threonine kinase activity 0.703490254739121 bayes_pls_golite062009
cell surface binding 0.694105914814106 bayes_pls_golite062009
kinase binding 0.65927255037265 bayes_pls_golite062009
DNA binding 0.609787884452433 bayes_pls_golite062009
ciliary neurotrophic factor receptor activity 0.60649323348068 bayes_pls_golite062009
enzyme binding 0.60195860585095 bayes_pls_golite062009
identical protein binding 0.564711394496051 bayes_pls_golite062009
transmembrane receptor protein tyrosine kinase activity 0.554350228628563 bayes_pls_golite062009
peptide binding 0.47885601366674 bayes_pls_golite062009
transmembrane receptor protein kinase activity 0.46168925186147 bayes_pls_golite062009
protein kinase binding 0.405060010394646 bayes_pls_golite062009
interleukin-2 binding 0.240383688164201 bayes_pls_golite062009
SH2 domain binding 0.218079243436961 bayes_pls_golite062009
structural molecule activity 0.18965275490219 bayes_pls_golite062009
protein homodimerization activity 0.116391819218123 bayes_pls_golite062009
integrin binding 0.0873424694168858 bayes_pls_golite062009
polysaccharide binding 0.0807821124164596 bayes_pls_golite062009
transcription factor activity 0.0148251912049181 bayes_pls_golite062009

Predicted Domain #6
Region A:
Residues: [957-1057] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VPGRVERFHP TDVQPSEINF EWSLPSSEAN GVIRQFSIAY TNINNLTDAG MQDFESEEAF  60
   61 GVIKNLKPGE TYVFKIQAKT AIGFGPEREY RQTMPILAPP R

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 10.30103
Match: 2docA
Description: No description for 2docA was found.

Predicted Domain #7
Region A:
Residues: [1058-1530] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PATQVVPTEV YRSSSTIQIR FRKNYFSDQN GQVRMYTIIV AEDDAKNASG LEMPSWLDVQ  60
   61 SYSVWLPYQA IDPYYPFENR SVEDFTIGTE NCDNHKIGYC NGPLKSGTTY RVKVRAFTGA 120
  121 DKFTDTAYSF PIQTDQDNTS LIVAITVPLT IILVLLVTLL FYKRRRNNCR KTTKDSRAND 180
  181 NMSLPDSVIE QNRPILIKNF AEHYRLMSAD SDFRFSEEFE ELKHVGRDQP CTFADLPCNR 240
  241 PKNRFTNILP YDHSRFKLQP VDDDEGSDYI NANYVPGHNS PREFIVTQGP LHSTRDDFWR 300
  301 MCWESNSRAI VMLTRCFEKG REKCDQYWPN DTVPVFYGDI KVQILNDSHY ADWVMTEFML 360
  361 CRGSEQRILR HFHFTTWPDF GVPNPPQTLV RFVRAFRDRI GAEQRPIVVH CSAGVGRSGT 420
  421 FITLDRILQQ INTSDYVDIF GIVYAMRKER VWMVQTEQQY ICIHQCLLAV LEG

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 78.522879
Match: 2shpA
Description: Tyrosine phosphatase; Tyrosine phoshatase shp-2
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transmembrane receptor protein phosphatase activity 4.57221148210263 bayes_pls_golite062009
transmembrane receptor protein tyrosine phosphatase activity 4.57221148210263 bayes_pls_golite062009
insulin receptor binding 3.48393497211158 bayes_pls_golite062009
protein binding 3.19631993182765 bayes_pls_golite062009
molecular transducer activity 3.13508395312263 bayes_pls_golite062009
signal transducer activity 3.13508395312263 bayes_pls_golite062009
transmembrane receptor activity 2.88026473691221 bayes_pls_golite062009
protein tyrosine/serine/threonine phosphatase activity 2.77531895423367 bayes_pls_golite062009
phosphoric ester hydrolase activity 2.76609604594837 bayes_pls_golite062009
binding 2.69791297400248 bayes_pls_golite062009
receptor activity 2.63187639411639 bayes_pls_golite062009
protein serine/threonine phosphatase activity 2.49496709551693 bayes_pls_golite062009
phosphatase activity 2.39617614358425 bayes_pls_golite062009
phosphoprotein phosphatase activity 2.32814368667748 bayes_pls_golite062009
hydrolase activity, acting on ester bonds 2.22704087268457 bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor 1.85015570449703 bayes_pls_golite062009
molecular adaptor activity 1.81145713371725 bayes_pls_golite062009
kinase activity 1.78069536883109 bayes_pls_golite062009
protein kinase activity 1.64363774024605 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 1.59739467025045 bayes_pls_golite062009
SH3/SH2 adaptor activity 1.59474164216385 bayes_pls_golite062009
cell adhesion molecule binding 1.53727496158735 bayes_pls_golite062009
receptor binding 1.52843393025918 bayes_pls_golite062009
epidermal growth factor receptor binding 1.24312972088703 bayes_pls_golite062009
transporter activity 1.21792561830727 bayes_pls_golite062009
transferase activity 1.19152443245584 bayes_pls_golite062009
inositol or phosphatidylinositol phosphatase activity 1.1200449509328 bayes_pls_golite062009
lipid phosphatase activity 1.05085928819585 bayes_pls_golite062009
phosphoinositide 3-kinase regulator activity 1.03150090191995 bayes_pls_golite062009
beta-catenin binding 1.02079992407668 bayes_pls_golite062009
protein tyrosine phosphatase activity 1.01632327679132 bayes_pls_golite062009
transmembrane transporter activity 1.00030784939308 bayes_pls_golite062009
insulin-like growth factor receptor binding 0.950445630788802 bayes_pls_golite062009
delta-catenin binding 0.89195134506409 bayes_pls_golite062009
protein binding, bridging 0.83823250804321 bayes_pls_golite062009
transcription regulator activity 0.788214946046252 bayes_pls_golite062009
substrate-specific transporter activity 0.73846553033987 bayes_pls_golite062009
nucleic acid binding 0.698379043283481 bayes_pls_golite062009
protein complex binding 0.65988681496356 bayes_pls_golite062009
protein phosphorylated amino acid binding 0.649814096718101 bayes_pls_golite062009
DNA binding 0.580632851213551 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 0.49044345981587 bayes_pls_golite062009
phospholipase binding 0.43589778800599 bayes_pls_golite062009
phosphotyrosine binding 0.311079584914389 bayes_pls_golite062009
insulin receptor substrate binding 0.29798436765753 bayes_pls_golite062009
phosphatidylinositol trisphosphate phosphatase activity 0.28805451968625 bayes_pls_golite062009
peptide hormone receptor binding 0.272080084933271 bayes_pls_golite062009
protein tyrosine kinase activity 0.206747304356052 bayes_pls_golite062009
ion transmembrane transporter activity 0.200180223985633 bayes_pls_golite062009
phosphoprotein binding 0.16798254471727 bayes_pls_golite062009
kinase binding 0.131981353175621 bayes_pls_golite062009
receptor signaling protein activity 0.0443241110585009 bayes_pls_golite062009
transcription factor activity 0.0308501288849649 bayes_pls_golite062009

Predicted Domain #8
Region A:
Residues: [1531-1631] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KENIVGPARE MHDNEGYEGQ QVQLDENGDV VATIEGHLSH HDLQQAEAEA IDDENAAILH  60
   61 DDQQPLTSSF TGHHTHMPPT TSMSSFGGGG GGHTNVDAPD R

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 142.0
Match: 2fh7A
Description: Crystal structure of the phosphatase domains of human PTP SIGMA
Matching Structure (courtesy of the PDB):
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle