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Protein Overview: Ptp10D-PA, Ptp10D-PD

General Information:
Name(s) found: Ptp10D-PD / FBpp0089120 [FlyBase]
Ptp10D-PA / FBpp0089119 [FlyBase]
Description(s) found:
Found 20 descriptions.
SHOW ALL
  • The gene Protein tyrosine phosphatase 10D is referred to in FlyBase by the symbol Dmel\Ptp10D (CG1817, FBgn0004370). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is X:11516061..11571371. It has the cytological map location 10D1-10D4. There is experimental evidence that it has the molecular function</span>: phosphoprotein phosphatase activity; protein tyrosine phosphatase activity. There is experimental evidence that it is involved in the biological process</span>: protein amino acid dephosphorylation. 39 alleles are reported. The phenotypes of these alleles are annotated with: macrochaeta; larval optic neuropil; intersegmental nerve. It has 4 annotated transcripts and 4 annotated polypeptides. [FlyBase]
  • The gene Protein tyrosine phosphatase 10D is referred to in FlyBase by the symbol Dmel\Ptp10D (CG1817, FBgn0004370). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is X:11516061..11571371. It has the cytological map location 10D1-10D4. There is experimental evidence that it has the molecular function</span>: phosphoprotein phosphatase activity; protein tyrosine phosphatase activity. There is experimental evidence that it is involved in the biological process</span>: protein amino acid dephosphorylation. 39 alleles are reported. The phenotypes of these alleles are annotated with: macrochaeta; larval optic neuropil; intersegmental nerve. It has 4 annotated transcripts and 4 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 1962 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: NONE FOUND
    Molecular Function: NONE FOUND


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLYQLSKATT RIRLKRQKAV PQHRWLWSLA FLAAFTLKDV RCADLAISIP NNPGLDDGAS  60
   61 YRLDYSPPFG YPEPNTTIAS REIGDEIQFS RALPGTKYNF WLYYTNFTHH DWLTWTVTIT 120
  121 TAPDPPSNLS VQVRSGKNAI ILWSPPTQGS YTAFKIKVLG LSEASSSYNR TFQVNDNTFQ 180
  181 HSVKELTPGA TYQVQAYTIY DGKESVAYTS RNFTTKPNTP GKFIVWFRNE TTLLVLWQPP 240
  241 YPAGIYTHYK VSIEPPDAND SVLYVEKEGE PPGPAQAAFK GLVPGRAYNI SVQTMSEDEI 300
  301 SLPTTAQYRT VPLRPLNVTF DRDFITSNSF RVLWEAPKGI SEFDKYQVSV ATTRRQSTVP 360
  361 RSNEPVAFFD FRDIAEPGKT FNVIVKTVSG KVTSWPATGD VTLRPLPVRN LRSINDDKTN 420
  421 TMIITWEADP ASTQDEYRIV YHELETFNGD TSTLTTDRTR FTLESLLPGR NYSLSVQAVS 480
  481 KKMESNETSI FVVTRPSSPI IEDLKSIRMG LNISWKSDVN SKQEQYEVLY SRNGTSDLRT 540
  541 QKTKESRLVI KNLQPGAGYE LKVFAVSHDL RSEPHAYFQA VYPNPPRNMT IETVRSNSVL 600
  601 VHWSPPESGE FTEYSIRYRT DSEQQWVRLP SVRSTEADIT DMTKGEKYTI QVNTVSFGVE 660
  661 SPVPQEVNTT VPPNPVSNII QLVDSRNITL EWPKPEGRVE SYILKWWPSD NPGRVQTKNV 720
  721 SENKSADDLS TVRVLIGELM PGVQYKFDIQ TTSYGILSGI TSLYPRTMPL IQSDVVVANG 780
  781 EKEDERDTIT LSYTPTPQSS SKFDIYRFSL GDAEIRDKEK LANDTDRKVT FTGLVPGRLY 840
  841 NITVWTVSGG VASLPIQRQD RLYPEPITQL HATNITDTEI SLRWDLPKGE YNDFDIAYLT 900
  901 ADNLLAQNMT TRNEITISDL RPHRNYTFTV VVRSGTESSV LRSSSPLSAS FTTNEAVPGR 960
  961 VERFHPTDVQ PSEINFEWSL PSSEANGVIR QFSIAYTNIN NLTDAGMQDF ESEEAFGVIK1020
 1021 NLKPGETYVF KIQAKTAIGF GPEREYRQTM PILAPPRPAT QVVPTEVYRS SSTIQIRFRK1080
 1081 NYFSDQNGQV RMYTIIVAED DAKNASGLEM PSWLDVQSYS VWLPYQAIDP YYPFENRSVE1140
 1141 DFTIGTENCD NHKIGYCNGP LKSGTTYRVK VRAFTGADKF TDTAYSFPIQ TDQDNTSLIV1200
 1201 AITVPLTIIL VLLVTLLFYK RRRNNCRKTT KDSRANDNMS LPDSVIEQNR PILIKNFAEH1260
 1261 YRLMSADSDF RFSEEFEELK HVGRDQPCTF ADLPCNRPKN RFTNILPYDH SRFKLQPVDD1320
 1321 DEGSDYINAN YVPGHNSPRE FIVTQGPLHS TRDDFWRMCW ESNSRAIVML TRCFEKGREK1380
 1381 CDQYWPNDTV PVFYGDIKVQ ILNDSHYADW VMTEFMLCRG SEQRILRHFH FTTWPDFGVP1440
 1441 NPPQTLVRFV RAFRDRIGAE QRPIVVHCSA GVGRSGTFIT LDRILQQINT SDYVDIFGIV1500
 1501 YAMRKERVWM VQTEQQYICI HQCLLAVLEG KENIVGPARE MHDNEGYEGQ QVQLDENGDV1560
 1561 VATIEGHLSH HDLQQAEAEA IDDENAAILH DDQQPLTSSF TGHHTHMPPT TSMSSFGGGG1620
 1621 GGHTNPSSMI CKDSKGGNID VLESQQQQQQ QQQQQPNQGG HNITTISAIN GYNTLQHRRK1680
 1681 SQLITFSSSS CDIKNSLSHE YINGSNGSAA NGPPSSGSGS GSGPGSNRAS RANVRLSFAE1740
 1741 EDVMILPQNH SQQSNHQDDE VFTRRRSLLE VEIGVEVGED GELAPHEMEE DLEEEDEDEE1800
 1801 LYMHDEFETH IDTKSNNAND DSGGGSYEDS HALHSSLGGS NRNSLEKDDD DIEVDVISTD1860
 1861 VSCYDQLLGS SCNTRNGDDD DIATLVGDGD YSTTKLSKAS RLSGAGVGGL VVSGGGGGTA1920
 1921 IGGGIAVNGG GVLGNGVGSE AGGGIIYANP FMDDEGIAES GM

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..69] PSI-BLAST 46.221849 No description for 2v5yA was found.
    2 View Details [70..145] PSI-BLAST 11.0 Cytokine receptor gp130 cytokine-binding domains
    3 View Details [146..755] PSI-BLAST 18.09691 Model of human carcinoembryonic antigen by homology modelling and curve-fitting to experimental solution scattering data
    4 View Details [756..861] PSI-BLAST 9.09691 Growth hormone receptor
    5 View Details [862..953] PSI-BLAST 51.39794 FRAGMENT OF HUMAN FIBRONECTIN ENCOMPASSING TYPE-III REPEATS 7 THROUGH 10
    6 View Details [954..1053] PSI-BLAST 10.522879 The solution structure of the first fibronectin type III domain of human Neogenin
    7 View Details [1054..1246] PSI-BLAST 78.69897 Crystal structure of human tyrosine phosphatase SHP-1
    8 View Details [1247..1819] PSI-BLAST 1000.0 Crystal structure of the phosphatase domains of human PTP SIGMA
    9 View Details [1820..1962] FFAS03 1.0 Verotoxin-1/shiga-toxin, B-pentamer

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • transmembrane receptor activity
    		•  4.21125462030555 bayes_pls_golite062009
  • receptor activity
    		•  4.09185309744435 bayes_pls_golite062009
  • protein binding
    		•  3.24522318184038 bayes_pls_golite062009
  • molecular transducer activity
    		•  3.24090483126624 bayes_pls_golite062009
  • signal transducer activity
    		•  3.24090483126624 bayes_pls_golite062009
  • cytokine binding
    		•  3.21238178184503 bayes_pls_golite062009
  • growth factor binding
    		•  2.99437744892471 bayes_pls_golite062009
  • cytokine receptor activity
    		•  2.76876397305497 bayes_pls_golite062009
  • binding
    		•  2.69537882298808 bayes_pls_golite062009
  • cell adhesion molecule binding
    		•  2.32179186005318 bayes_pls_golite062009
  • axon guidance receptor activity
    		•  2.01367445237355 bayes_pls_golite062009
  • peptide hormone binding
    		•  1.9205359237864 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  1.61421027298524 bayes_pls_golite062009
  • protein kinase activity
    		•  1.60674218431738 bayes_pls_golite062009
  • kinase activity
    		•  1.57994485110649 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  1.44501485815273 bayes_pls_golite062009
  • receptor binding
    		•  1.31676259534833 bayes_pls_golite062009
  • hormone binding
    		•  1.31120662451488 bayes_pls_golite062009
  • interleukin-6 receptor activity
    		•  1.18385625326067 bayes_pls_golite062009
  • interleukin-6 binding
    		•  1.18385625326067 bayes_pls_golite062009
  • transferase activity
    		•  1.13635878582843 bayes_pls_golite062009
  • protein dimerization activity
    		•  0.86564366658585 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.745125737480015 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.718355770608923 bayes_pls_golite062009
  • protein serine/threonine kinase activity
    		•  0.703490254739121 bayes_pls_golite062009
  • cell surface binding
    		•  0.694105914814106 bayes_pls_golite062009
  • kinase binding
    		•  0.65927255037265 bayes_pls_golite062009
  • DNA binding
    		•  0.609787884452433 bayes_pls_golite062009
  • ciliary neurotrophic factor receptor activity
    		•  0.60649323348068 bayes_pls_golite062009
  • enzyme binding
    		•  0.60195860585095 bayes_pls_golite062009
  • identical protein binding
    		•  0.564711394496051 bayes_pls_golite062009
  • transmembrane receptor protein tyrosine kinase activity
    		•  0.554350228628563 bayes_pls_golite062009
  • peptide binding
    		•  0.47885601366674 bayes_pls_golite062009
  • transmembrane receptor protein kinase activity
    		•  0.46168925186147 bayes_pls_golite062009
  • protein kinase binding
    		•  0.405060010394646 bayes_pls_golite062009
  • interleukin-2 binding
    		•  0.240383688164201 bayes_pls_golite062009
  • SH2 domain binding
    		•  0.218079243436961 bayes_pls_golite062009
  • structural molecule activity
    		•  0.18965275490219 bayes_pls_golite062009
  • protein homodimerization activity
    		•  0.116391819218123 bayes_pls_golite062009
  • integrin binding
    		•  0.0873424694168858 bayes_pls_golite062009
  • polysaccharide binding
    		•  0.0807821124164596 bayes_pls_golite062009
  • transcription factor activity
    		•  0.0148251912049181 bayes_pls_golite062009
    3 No functions predicted.
    4
    Term Confidence Notes
  • transmembrane receptor activity
    		•  4.21125462030555 bayes_pls_golite062009
  • receptor activity
    		•  4.09185309744435 bayes_pls_golite062009
  • protein binding
    		•  3.24522318184038 bayes_pls_golite062009
  • molecular transducer activity
    		•  3.24090483126624 bayes_pls_golite062009
  • signal transducer activity
    		•  3.24090483126624 bayes_pls_golite062009
  • cytokine binding
    		•  3.21238178184503 bayes_pls_golite062009
  • growth factor binding
    		•  2.99437744892471 bayes_pls_golite062009
  • cytokine receptor activity
    		•  2.76876397305497 bayes_pls_golite062009
  • binding
    		•  2.69537882298808 bayes_pls_golite062009
  • cell adhesion molecule binding
    		•  2.32179186005318 bayes_pls_golite062009
  • axon guidance receptor activity
    		•  2.01367445237355 bayes_pls_golite062009
  • peptide hormone binding
    		•  1.9205359237864 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  1.61421027298524 bayes_pls_golite062009
  • protein kinase activity
    		•  1.60674218431738 bayes_pls_golite062009
  • kinase activity
    		•  1.57994485110649 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  1.44501485815273 bayes_pls_golite062009
  • receptor binding
    		•  1.31676259534833 bayes_pls_golite062009
  • hormone binding
    		•  1.31120662451488 bayes_pls_golite062009
  • interleukin-6 receptor activity
    		•  1.18385625326067 bayes_pls_golite062009
  • interleukin-6 binding
    		•  1.18385625326067 bayes_pls_golite062009
  • transferase activity
    		•  1.13635878582843 bayes_pls_golite062009
  • protein dimerization activity
    		•  0.86564366658585 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.745125737480015 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.718355770608923 bayes_pls_golite062009
  • protein serine/threonine kinase activity
    		•  0.703490254739121 bayes_pls_golite062009
  • cell surface binding
    		•  0.694105914814106 bayes_pls_golite062009
  • kinase binding
    		•  0.65927255037265 bayes_pls_golite062009
  • DNA binding
    		•  0.609787884452433 bayes_pls_golite062009
  • ciliary neurotrophic factor receptor activity
    		•  0.60649323348068 bayes_pls_golite062009
  • enzyme binding
    		•  0.60195860585095 bayes_pls_golite062009
  • identical protein binding
    		•  0.564711394496051 bayes_pls_golite062009
  • transmembrane receptor protein tyrosine kinase activity
    		•  0.554350228628563 bayes_pls_golite062009
  • peptide binding
    		•  0.47885601366674 bayes_pls_golite062009
  • transmembrane receptor protein kinase activity
    		•  0.46168925186147 bayes_pls_golite062009
  • protein kinase binding
    		•  0.405060010394646 bayes_pls_golite062009
  • interleukin-2 binding
    		•  0.240383688164201 bayes_pls_golite062009
  • SH2 domain binding
    		•  0.218079243436961 bayes_pls_golite062009
  • structural molecule activity
    		•  0.18965275490219 bayes_pls_golite062009
  • protein homodimerization activity
    		•  0.116391819218123 bayes_pls_golite062009
  • integrin binding
    		•  0.0873424694168858 bayes_pls_golite062009
  • polysaccharide binding
    		•  0.0807821124164596 bayes_pls_golite062009
  • transcription factor activity
    		•  0.0148251912049181 bayes_pls_golite062009
    5 No functions predicted.
    6
    Term Confidence Notes
  • transmembrane receptor activity
    		•  4.21125462030555 bayes_pls_golite062009
  • receptor activity
    		•  4.09185309744435 bayes_pls_golite062009
  • protein binding
    		•  3.24522318184038 bayes_pls_golite062009
  • molecular transducer activity
    		•  3.24090483126624 bayes_pls_golite062009
  • signal transducer activity
    		•  3.24090483126624 bayes_pls_golite062009
  • cytokine binding
    		•  3.21238178184503 bayes_pls_golite062009
  • growth factor binding
    		•  2.99437744892471 bayes_pls_golite062009
  • cytokine receptor activity
    		•  2.76876397305497 bayes_pls_golite062009
  • binding
    		•  2.69537882298808 bayes_pls_golite062009
  • cell adhesion molecule binding
    		•  2.32179186005318 bayes_pls_golite062009
  • axon guidance receptor activity
    		•  2.01367445237355 bayes_pls_golite062009
  • peptide hormone binding
    		•  1.9205359237864 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  1.61421027298524 bayes_pls_golite062009
  • protein kinase activity
    		•  1.60674218431738 bayes_pls_golite062009
  • kinase activity
    		•  1.57994485110649 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  1.44501485815273 bayes_pls_golite062009
  • receptor binding
    		•  1.31676259534833 bayes_pls_golite062009
  • hormone binding
    		•  1.31120662451488 bayes_pls_golite062009
  • interleukin-6 receptor activity
    		•  1.18385625326067 bayes_pls_golite062009
  • interleukin-6 binding
    		•  1.18385625326067 bayes_pls_golite062009
  • transferase activity
    		•  1.13635878582843 bayes_pls_golite062009
  • protein dimerization activity
    		•  0.86564366658585 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.745125737480015 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.718355770608923 bayes_pls_golite062009
  • protein serine/threonine kinase activity
    		•  0.703490254739121 bayes_pls_golite062009
  • cell surface binding
    		•  0.694105914814106 bayes_pls_golite062009
  • kinase binding
    		•  0.65927255037265 bayes_pls_golite062009
  • DNA binding
    		•  0.609787884452433 bayes_pls_golite062009
  • ciliary neurotrophic factor receptor activity
    		•  0.60649323348068 bayes_pls_golite062009
  • enzyme binding
    		•  0.60195860585095 bayes_pls_golite062009
  • identical protein binding
    		•  0.564711394496051 bayes_pls_golite062009
  • transmembrane receptor protein tyrosine kinase activity
    		•  0.554350228628563 bayes_pls_golite062009
  • peptide binding
    		•  0.47885601366674 bayes_pls_golite062009
  • transmembrane receptor protein kinase activity
    		•  0.46168925186147 bayes_pls_golite062009
  • protein kinase binding
    		•  0.405060010394646 bayes_pls_golite062009
  • interleukin-2 binding
    		•  0.240383688164201 bayes_pls_golite062009
  • SH2 domain binding
    		•  0.218079243436961 bayes_pls_golite062009
  • structural molecule activity
    		•  0.18965275490219 bayes_pls_golite062009
  • protein homodimerization activity
    		•  0.116391819218123 bayes_pls_golite062009
  • integrin binding
    		•  0.0873424694168858 bayes_pls_golite062009
  • polysaccharide binding
    		•  0.0807821124164596 bayes_pls_golite062009
  • transcription factor activity
    		•  0.0148251912049181 bayes_pls_golite062009
    7 No functions predicted.
    8 No functions predicted.
    9
    Term Confidence Notes
  • binding
    		•  1.80844731037991 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle