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View Structure Prediction Details

Protein: Ptp10D-PA, Ptp10D-PD
Organism: Drosophila melanogaster
Length: 1962 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for Ptp10D-PA, Ptp10D-PD.

Description E-value Query
Range		 Subject
Range
gi|125983768, gi... - gi|54643965|gb|EAL32708.1| GA14821-PA [Drosophila pseudoobscura], gi|125983768|ref|XP_001355649.1| G...
 1234.0 [0..23] [1962..127]

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Predicted Domain #1
Region A:
Residues: [1-69] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLYQLSKATT RIRLKRQKAV PQHRWLWSLA FLAAFTLKDV RCADLAISIP NNPGLDDGAS  60
   61 YRLDYSPPF

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 46.221849
Match: 2v5yA
Description: No description for 2v5yA was found.

Predicted Domain #2
Region A:
Residues: [70-145] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GYPEPNTTIA SREIGDEIQF SRALPGTKYN FWLYYTNFTH HDWLTWTVTI TTAPDPPSNL  60
   61 SVQVRSGKNA IILWSP

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 11.0
Match: 1i1rA
Description: Cytokine receptor gp130 cytokine-binding domains
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transmembrane receptor activity 4.21125462030555 bayes_pls_golite062009
receptor activity 4.09185309744435 bayes_pls_golite062009
protein binding 3.24522318184038 bayes_pls_golite062009
molecular transducer activity 3.24090483126624 bayes_pls_golite062009
signal transducer activity 3.24090483126624 bayes_pls_golite062009
cytokine binding 3.21238178184503 bayes_pls_golite062009
growth factor binding 2.99437744892471 bayes_pls_golite062009
cytokine receptor activity 2.76876397305497 bayes_pls_golite062009
binding 2.69537882298808 bayes_pls_golite062009
cell adhesion molecule binding 2.32179186005318 bayes_pls_golite062009
axon guidance receptor activity 2.01367445237355 bayes_pls_golite062009
peptide hormone binding 1.9205359237864 bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor 1.61421027298524 bayes_pls_golite062009
protein kinase activity 1.60674218431738 bayes_pls_golite062009
kinase activity 1.57994485110649 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 1.44501485815273 bayes_pls_golite062009
receptor binding 1.31676259534833 bayes_pls_golite062009
hormone binding 1.31120662451488 bayes_pls_golite062009
interleukin-6 receptor activity 1.18385625326067 bayes_pls_golite062009
interleukin-6 binding 1.18385625326067 bayes_pls_golite062009
transferase activity 1.13635878582843 bayes_pls_golite062009
protein dimerization activity 0.86564366658585 bayes_pls_golite062009
nucleic acid binding 0.745125737480015 bayes_pls_golite062009
transcription regulator activity 0.718355770608923 bayes_pls_golite062009
protein serine/threonine kinase activity 0.703490254739121 bayes_pls_golite062009
cell surface binding 0.694105914814106 bayes_pls_golite062009
kinase binding 0.65927255037265 bayes_pls_golite062009
DNA binding 0.609787884452433 bayes_pls_golite062009
ciliary neurotrophic factor receptor activity 0.60649323348068 bayes_pls_golite062009
enzyme binding 0.60195860585095 bayes_pls_golite062009
identical protein binding 0.564711394496051 bayes_pls_golite062009
transmembrane receptor protein tyrosine kinase activity 0.554350228628563 bayes_pls_golite062009
peptide binding 0.47885601366674 bayes_pls_golite062009
transmembrane receptor protein kinase activity 0.46168925186147 bayes_pls_golite062009
protein kinase binding 0.405060010394646 bayes_pls_golite062009
interleukin-2 binding 0.240383688164201 bayes_pls_golite062009
SH2 domain binding 0.218079243436961 bayes_pls_golite062009
structural molecule activity 0.18965275490219 bayes_pls_golite062009
protein homodimerization activity 0.116391819218123 bayes_pls_golite062009
integrin binding 0.0873424694168858 bayes_pls_golite062009
polysaccharide binding 0.0807821124164596 bayes_pls_golite062009
transcription factor activity 0.0148251912049181 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [146-755] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PTQGSYTAFK IKVLGLSEAS SSYNRTFQVN DNTFQHSVKE LTPGATYQVQ AYTIYDGKES  60
   61 VAYTSRNFTT KPNTPGKFIV WFRNETTLLV LWQPPYPAGI YTHYKVSIEP PDANDSVLYV 120
  121 EKEGEPPGPA QAAFKGLVPG RAYNISVQTM SEDEISLPTT AQYRTVPLRP LNVTFDRDFI 180
  181 TSNSFRVLWE APKGISEFDK YQVSVATTRR QSTVPRSNEP VAFFDFRDIA EPGKTFNVIV 240
  241 KTVSGKVTSW PATGDVTLRP LPVRNLRSIN DDKTNTMIIT WEADPASTQD EYRIVYHELE 300
  301 TFNGDTSTLT TDRTRFTLES LLPGRNYSLS VQAVSKKMES NETSIFVVTR PSSPIIEDLK 360
  361 SIRMGLNISW KSDVNSKQEQ YEVLYSRNGT SDLRTQKTKE SRLVIKNLQP GAGYELKVFA 420
  421 VSHDLRSEPH AYFQAVYPNP PRNMTIETVR SNSVLVHWSP PESGEFTEYS IRYRTDSEQQ 480
  481 WVRLPSVRST EADITDMTKG EKYTIQVNTV SFGVESPVPQ EVNTTVPPNP VSNIIQLVDS 540
  541 RNITLEWPKP EGRVESYILK WWPSDNPGRV QTKNVSENKS ADDLSTVRVL IGELMPGVQY 600
  601 KFDIQTTSYG

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 18.09691
Match: 1e07A
Description: Model of human carcinoembryonic antigen by homology modelling and curve-fitting to experimental solution scattering data
Matching Structure (courtesy of the PDB):

Predicted Domain #4
Region A:
Residues: [756-861] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ILSGITSLYP RTMPLIQSDV VVANGEKEDE RDTITLSYTP TPQSSSKFDI YRFSLGDAEI  60
   61 RDKEKLANDT DRKVTFTGLV PGRLYNITVW TVSGGVASLP IQRQDR

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 9.09691
Match: 1axiB
Description: Growth hormone receptor
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transmembrane receptor activity 4.21125462030555 bayes_pls_golite062009
receptor activity 4.09185309744435 bayes_pls_golite062009
protein binding 3.24522318184038 bayes_pls_golite062009
molecular transducer activity 3.24090483126624 bayes_pls_golite062009
signal transducer activity 3.24090483126624 bayes_pls_golite062009
cytokine binding 3.21238178184503 bayes_pls_golite062009
growth factor binding 2.99437744892471 bayes_pls_golite062009
cytokine receptor activity 2.76876397305497 bayes_pls_golite062009
binding 2.69537882298808 bayes_pls_golite062009
cell adhesion molecule binding 2.32179186005318 bayes_pls_golite062009
axon guidance receptor activity 2.01367445237355 bayes_pls_golite062009
peptide hormone binding 1.9205359237864 bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor 1.61421027298524 bayes_pls_golite062009
protein kinase activity 1.60674218431738 bayes_pls_golite062009
kinase activity 1.57994485110649 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 1.44501485815273 bayes_pls_golite062009
receptor binding 1.31676259534833 bayes_pls_golite062009
hormone binding 1.31120662451488 bayes_pls_golite062009
interleukin-6 receptor activity 1.18385625326067 bayes_pls_golite062009
interleukin-6 binding 1.18385625326067 bayes_pls_golite062009
transferase activity 1.13635878582843 bayes_pls_golite062009
protein dimerization activity 0.86564366658585 bayes_pls_golite062009
nucleic acid binding 0.745125737480015 bayes_pls_golite062009
transcription regulator activity 0.718355770608923 bayes_pls_golite062009
protein serine/threonine kinase activity 0.703490254739121 bayes_pls_golite062009
cell surface binding 0.694105914814106 bayes_pls_golite062009
kinase binding 0.65927255037265 bayes_pls_golite062009
DNA binding 0.609787884452433 bayes_pls_golite062009
ciliary neurotrophic factor receptor activity 0.60649323348068 bayes_pls_golite062009
enzyme binding 0.60195860585095 bayes_pls_golite062009
identical protein binding 0.564711394496051 bayes_pls_golite062009
transmembrane receptor protein tyrosine kinase activity 0.554350228628563 bayes_pls_golite062009
peptide binding 0.47885601366674 bayes_pls_golite062009
transmembrane receptor protein kinase activity 0.46168925186147 bayes_pls_golite062009
protein kinase binding 0.405060010394646 bayes_pls_golite062009
interleukin-2 binding 0.240383688164201 bayes_pls_golite062009
SH2 domain binding 0.218079243436961 bayes_pls_golite062009
structural molecule activity 0.18965275490219 bayes_pls_golite062009
protein homodimerization activity 0.116391819218123 bayes_pls_golite062009
integrin binding 0.0873424694168858 bayes_pls_golite062009
polysaccharide binding 0.0807821124164596 bayes_pls_golite062009
transcription factor activity 0.0148251912049181 bayes_pls_golite062009

Predicted Domain #5
Region A:
Residues: [862-953] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LYPEPITQLH ATNITDTEIS LRWDLPKGEY NDFDIAYLTA DNLLAQNMTT RNEITISDLR  60
   61 PHRNYTFTVV VRSGTESSVL RSSSPLSASF TT

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 51.39794
Match: 1fnfA
Description: FRAGMENT OF HUMAN FIBRONECTIN ENCOMPASSING TYPE-III REPEATS 7 THROUGH 10
Matching Structure (courtesy of the PDB):

Predicted Domain #6
Region A:
Residues: [954-1053] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NEAVPGRVER FHPTDVQPSE INFEWSLPSS EANGVIRQFS IAYTNINNLT DAGMQDFESE  60
   61 EAFGVIKNLK PGETYVFKIQ AKTAIGFGPE REYRQTMPIL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 10.522879
Match: 1x5fA
Description: The solution structure of the first fibronectin type III domain of human Neogenin
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transmembrane receptor activity 4.21125462030555 bayes_pls_golite062009
receptor activity 4.09185309744435 bayes_pls_golite062009
protein binding 3.24522318184038 bayes_pls_golite062009
molecular transducer activity 3.24090483126624 bayes_pls_golite062009
signal transducer activity 3.24090483126624 bayes_pls_golite062009
cytokine binding 3.21238178184503 bayes_pls_golite062009
growth factor binding 2.99437744892471 bayes_pls_golite062009
cytokine receptor activity 2.76876397305497 bayes_pls_golite062009
binding 2.69537882298808 bayes_pls_golite062009
cell adhesion molecule binding 2.32179186005318 bayes_pls_golite062009
axon guidance receptor activity 2.01367445237355 bayes_pls_golite062009
peptide hormone binding 1.9205359237864 bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor 1.61421027298524 bayes_pls_golite062009
protein kinase activity 1.60674218431738 bayes_pls_golite062009
kinase activity 1.57994485110649 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 1.44501485815273 bayes_pls_golite062009
receptor binding 1.31676259534833 bayes_pls_golite062009
hormone binding 1.31120662451488 bayes_pls_golite062009
interleukin-6 receptor activity 1.18385625326067 bayes_pls_golite062009
interleukin-6 binding 1.18385625326067 bayes_pls_golite062009
transferase activity 1.13635878582843 bayes_pls_golite062009
protein dimerization activity 0.86564366658585 bayes_pls_golite062009
nucleic acid binding 0.745125737480015 bayes_pls_golite062009
transcription regulator activity 0.718355770608923 bayes_pls_golite062009
protein serine/threonine kinase activity 0.703490254739121 bayes_pls_golite062009
cell surface binding 0.694105914814106 bayes_pls_golite062009
kinase binding 0.65927255037265 bayes_pls_golite062009
DNA binding 0.609787884452433 bayes_pls_golite062009
ciliary neurotrophic factor receptor activity 0.60649323348068 bayes_pls_golite062009
enzyme binding 0.60195860585095 bayes_pls_golite062009
identical protein binding 0.564711394496051 bayes_pls_golite062009
transmembrane receptor protein tyrosine kinase activity 0.554350228628563 bayes_pls_golite062009
peptide binding 0.47885601366674 bayes_pls_golite062009
transmembrane receptor protein kinase activity 0.46168925186147 bayes_pls_golite062009
protein kinase binding 0.405060010394646 bayes_pls_golite062009
interleukin-2 binding 0.240383688164201 bayes_pls_golite062009
SH2 domain binding 0.218079243436961 bayes_pls_golite062009
structural molecule activity 0.18965275490219 bayes_pls_golite062009
protein homodimerization activity 0.116391819218123 bayes_pls_golite062009
integrin binding 0.0873424694168858 bayes_pls_golite062009
polysaccharide binding 0.0807821124164596 bayes_pls_golite062009
transcription factor activity 0.0148251912049181 bayes_pls_golite062009

Predicted Domain #7
Region A:
Residues: [1054-1246] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 APPRPATQVV PTEVYRSSST IQIRFRKNYF SDQNGQVRMY TIIVAEDDAK NASGLEMPSW  60
   61 LDVQSYSVWL PYQAIDPYYP FENRSVEDFT IGTENCDNHK IGYCNGPLKS GTTYRVKVRA 120
  121 FTGADKFTDT AYSFPIQTDQ DNTSLIVAIT VPLTIILVLL VTLLFYKRRR NNCRKTTKDS 180
  181 RANDNMSLPD SVI

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 78.69897
Match: 2b3oA
Description: Crystal structure of human tyrosine phosphatase SHP-1
Matching Structure (courtesy of the PDB):

Predicted Domain #8
Region A:
Residues: [1247-1819] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EQNRPILIKN FAEHYRLMSA DSDFRFSEEF EELKHVGRDQ PCTFADLPCN RPKNRFTNIL  60
   61 PYDHSRFKLQ PVDDDEGSDY INANYVPGHN SPREFIVTQG PLHSTRDDFW RMCWESNSRA 120
  121 IVMLTRCFEK GREKCDQYWP NDTVPVFYGD IKVQILNDSH YADWVMTEFM LCRGSEQRIL 180
  181 RHFHFTTWPD FGVPNPPQTL VRFVRAFRDR IGAEQRPIVV HCSAGVGRSG TFITLDRILQ 240
  241 QINTSDYVDI FGIVYAMRKE RVWMVQTEQQ YICIHQCLLA VLEGKENIVG PAREMHDNEG 300
  301 YEGQQVQLDE NGDVVATIEG HLSHHDLQQA EAEAIDDENA AILHDDQQPL TSSFTGHHTH 360
  361 MPPTTSMSSF GGGGGGHTNP SSMICKDSKG GNIDVLESQQ QQQQQQQQQP NQGGHNITTI 420
  421 SAINGYNTLQ HRRKSQLITF SSSSCDIKNS LSHEYINGSN GSAANGPPSS GSGSGSGPGS 480
  481 NRASRANVRL SFAEEDVMIL PQNHSQQSNH QDDEVFTRRR SLLEVEIGVE VGEDGELAPH 540
  541 EMEEDLEEED EDEELYMHDE FETHIDTKSN NAN

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 1000.0
Match: 2fh7A
Description: Crystal structure of the phosphatase domains of human PTP SIGMA
Matching Structure (courtesy of the PDB):

Predicted Domain #9
Region A:
Residues: [1820-1962] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DDSGGGSYED SHALHSSLGG SNRNSLEKDD DDIEVDVIST DVSCYDQLLG SSCNTRNGDD  60
   61 DDIATLVGDG DYSTTKLSKA SRLSGAGVGG LVVSGGGGGT AIGGGIAVNG GGVLGNGVGS 120
  121 EAGGGIIYAN PFMDDEGIAE SGM

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 1.0
Match: 1c4qA
Description: Verotoxin-1/shiga-toxin, B-pentamer
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 1.80844731037991 bayes_pls_golite062009
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle