| Protein: | Eph-PC |
| Organism: | Drosophila melanogaster |
| Length: | 1096 amino acids |
| Reference: | Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16 |
Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for Eph-PC.
| Description | E-value | Query Range |
Subject Range |
|
|
1026.0 | [0..46] | [1096..19] |
|
Region A: Residues: [1-80] |
1 11 21 31 41 51
| | | | | |
1 MKMVGCHPND KKVKYDGIKS KTSSVTILTS VLNDAISALK SAFYKNQAPI SEQNRSQIVS 60
61 RMSLLRTILL IIISIHFKLA
|
| Detection Method: |  |
Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.
Found no confident structure predictions for this domain.
|
Region A: Residues: [81-255] |
1 11 21 31 41 51
| | | | | |
1 HADQVVLLDT TREATLEWTR YPYGPQAQTP GWVEESFTDF VKGINWRSYV VCDVAYHNVN 60
61 NWLWSPFIDR GSANRLYIEI QFTIRDCSLF PGNALSCKET FSLLFYEFDA ATREPPPWQT 120
121 DSYRLIARIA AGEGRFNQNS DVDINTEVKS IAVNKKGVYF AFRDQGACIS VLAVK
|
| Detection Method: | |
| Confidence: | 83.522879 |
| Match: | 1nukA |
| Description: | Ligand-binding domain of the ephb2 receptor tyrosine kinase |
Matching Structure (courtesy of the PDB): |
|
| Term | Confidence | Notes |
| integrin binding | 3.61193098087012 | bayes_pls_golite062009 |
| transmembrane receptor activity | 2.80879825615822 | bayes_pls_golite062009 |
| receptor activity | 2.77268648576901 | bayes_pls_golite062009 |
| transmembrane receptor protein tyrosine kinase activity | 2.47762337031838 | bayes_pls_golite062009 |
| binding | 2.31774167130542 | bayes_pls_golite062009 |
| transmembrane receptor protein kinase activity | 2.23073603832866 | bayes_pls_golite062009 |
| phosphatidylserine binding | 2.22270974208755 | bayes_pls_golite062009 |
| molecular transducer activity | 2.03595043486636 | bayes_pls_golite062009 |
| signal transducer activity | 2.03595043486636 | bayes_pls_golite062009 |
| protein binding | 1.90867517664953 | bayes_pls_golite062009 |
| fucose binding | 1.72607684089801 | bayes_pls_golite062009 |
| protein kinase activity | 1.70755634087208 | bayes_pls_golite062009 |
| monosaccharide binding | 1.62596107035359 | bayes_pls_golite062009 |
| phosphotransferase activity, alcohol group as acceptor | 1.39122779055629 | bayes_pls_golite062009 |
| kinase activity | 1.31546222648513 | bayes_pls_golite062009 |
| transferase activity, transferring phosphorus-containing groups | 1.28997154411534 | bayes_pls_golite062009 |
| carbohydrate binding | 1.26743933952271 | bayes_pls_golite062009 |
| vascular endothelial growth factor receptor activity | 1.21634643105777 | bayes_pls_golite062009 |
| protein tyrosine kinase activity | 1.18833031215069 | bayes_pls_golite062009 |
| sugar binding | 1.1562287794497 | bayes_pls_golite062009 |
| glycoprotein binding | 0.68697655195721 | bayes_pls_golite062009 |
| protein complex binding | 0.56054373949313 | bayes_pls_golite062009 |
| nucleic acid binding | 0.533285414042183 | bayes_pls_golite062009 |
| transferase activity | 0.530643564656921 | bayes_pls_golite062009 |
| receptor binding | 0.365344483970243 | bayes_pls_golite062009 |
| DNA binding | 0.324772578014229 | bayes_pls_golite062009 |
| small conjugating protein ligase activity | 0.24891369301653 | bayes_pls_golite062009 |
| ubiquitin-protein ligase activity | 0.16022291279782 | bayes_pls_golite062009 |
| phosphatidylethanolamine binding | 0.121022714964449 | bayes_pls_golite062009 |
|
Region A: Residues: [256-680] |
1 11 21 31 41 51
| | | | | |
1 VYYITCPAVT ENFAHFNETP TGREITIIEK QNGTCVDNAE PYETPTYLCK GDGKWTILTG 60
61 GCRCKAGYEP NYTNKTCTEC PLGTFKSPEV TKCTPCPPNS NASKTGSPFC KCASGFYRHP 120
121 NDGRHMPCYS PPAAPTNLTL LFVDQTSAII SWSAPAKNES FSSETNSKIY HSDIVYKIKC 180
181 NICSPNVVYN PSTDTFNETK ITLTNLEPVT TYTVQIHAIN SVSHINEFKR HSNESSLVAV 240
241 SDIVFSNTSL LNIPLDLNEV KTGQAEIVFT TESVLLSTVF NLRILAITNK DADLEWDKPV 300
301 QSDFPLEFYE VRWFPKVELD AINKSALNTK ETKAHIVGLL ENTEYGFQVR CKTNNGFGSY 360
361 SNMIYAQTLQ SVGSVYDDSV QIRFIAGAIV TGVLFLVIFI IATVYFMRSK HQDDLDKKST 420
421 NHLPL
|
| Detection Method: | |
| Confidence: | 9.221849 |
| Match: | 1s78A |
| Description: | Insights into ErbB signaling from the structure of the ErbB2-pertuzumab complex |
Matching Structure (courtesy of the PDB): |
|
| Term | Confidence | Notes |
| growth factor binding | 6.33296746316446 | bayes_pls_golite062009 |
| insulin-like growth factor binding | 5.09204037654114 | bayes_pls_golite062009 |
| binding | 3.10942625145915 | bayes_pls_golite062009 |
| G-protein coupled receptor activity | 3.09281229196379 | bayes_pls_golite062009 |
| protein binding | 3.04595153576805 | bayes_pls_golite062009 |
| insulin-like growth factor I binding | 2.97927266804248 | bayes_pls_golite062009 |
| transmembrane receptor activity | 2.11274485218746 | bayes_pls_golite062009 |
| receptor activity | 2.04770371945982 | bayes_pls_golite062009 |
| glycosaminoglycan binding | 1.94753631697974 | bayes_pls_golite062009 |
| polysaccharide binding | 1.72554005663659 | bayes_pls_golite062009 |
| molecular transducer activity | 1.716940423168 | bayes_pls_golite062009 |
| signal transducer activity | 1.716940423168 | bayes_pls_golite062009 |
| protein kinase activity | 1.64316913174221 | bayes_pls_golite062009 |
| transmembrane receptor protein kinase activity | 1.50579173120225 | bayes_pls_golite062009 |
| integrin binding | 1.40983775289543 | bayes_pls_golite062009 |
| insulin-like growth factor II binding | 1.39804733127147 | bayes_pls_golite062009 |
| phosphotransferase activity, alcohol group as acceptor | 1.3823186140816 | bayes_pls_golite062009 |
| transmembrane receptor protein tyrosine kinase activity | 1.36671598599873 | bayes_pls_golite062009 |
| transferase activity, transferring phosphorus-containing groups | 1.35826958219514 | bayes_pls_golite062009 |
| kinase activity | 1.33897988039058 | bayes_pls_golite062009 |
| insulin-like growth factor receptor activity | 1.05533763659606 | bayes_pls_golite062009 |
| actin filament binding | 0.855558247588515 | bayes_pls_golite062009 |
| transferase activity | 0.694193657141457 | bayes_pls_golite062009 |
| protein tyrosine kinase activity | 0.625443680166071 | bayes_pls_golite062009 |
| enzyme regulator activity | 0.621654050156711 | bayes_pls_golite062009 |
| heparin binding | 0.596331166056362 | bayes_pls_golite062009 |
| epidermal growth factor receptor binding | 0.430075899423884 | bayes_pls_golite062009 |
| protein-hormone receptor activity | 0.42902267001067 | bayes_pls_golite062009 |
| glycoprotein binding | 0.41080910982871 | bayes_pls_golite062009 |
| nucleic acid binding | 0.370391722473665 | bayes_pls_golite062009 |
| receptor binding | 0.319201203357304 | bayes_pls_golite062009 |
| catalytic activity | 0.271811389148807 | bayes_pls_golite062009 |
| phosphatase activator activity | 0.234175951765568 | bayes_pls_golite062009 |
| pattern binding | 0.195655028782749 | bayes_pls_golite062009 |
| enzyme activator activity | 0.126307392530805 | bayes_pls_golite062009 |
|
Region A: Residues: [681-1015] |
1 11 21 31 41 51
| | | | | |
1 PLDYASNEVN SMDTTPIVKK LHLNVTTPLF GNSRSYVDPH TYEDPNQAIR EFAREIDANY 60
61 ITIEAIIGGG EFGDVCRGRL KIPPNFVQDI DVAIKTLKPG SSEKARCDFL TEASIMGQFD 120
121 HPNVIYLQGV VTRSNPVMII TEYMENGSLD TFLRVNDGKF QTLQLIVMLR GIASGMSYLS 180
181 DMNYVHRDLA ARNVLVNAQL ICKIADFGLS REIENASDAY TTRGGKIPVR WTAPEAIAFR 240
241 KFTSASDVWS YGVVLWEVMS YGERPYWNWS NQDVIKSIEK GYRLPAPMDC PEALYQLMLD 300
301 CWQKQRTHRP TFASIVSTLD NLARQPQSLL TTRPS
|
| Detection Method: | |
| Confidence: | 76.0 |
| Match: | 1jpaA |
| Description: | ephb2 receptor tyrosine kinase |
Matching Structure (courtesy of the PDB): |
|
| Term | Confidence | Notes |
| protein kinase activity | 5.4586557943719 | bayes_pls_golite062009 |
| phosphotransferase activity, alcohol group as acceptor | 5.04467222534257 | bayes_pls_golite062009 |
| kinase activity | 4.85903980916957 | bayes_pls_golite062009 |
| transferase activity, transferring phosphorus-containing groups | 4.63692708178478 | bayes_pls_golite062009 |
| protein serine/threonine kinase activity | 4.46381887831481 | bayes_pls_golite062009 |
| phosphoinositide 3-kinase binding | 3.43994026029707 | bayes_pls_golite062009 |
| transmembrane receptor protein tyrosine kinase activity | 3.41480681854114 | bayes_pls_golite062009 |
| transmembrane receptor protein kinase activity | 3.40140621607334 | bayes_pls_golite062009 |
| transferase activity | 3.26787750561728 | bayes_pls_golite062009 |
| transmembrane receptor activity | 3.1965684217331 | bayes_pls_golite062009 |
| receptor activity | 2.96273889901429 | bayes_pls_golite062009 |
| molecular transducer activity | 2.85730457922199 | bayes_pls_golite062009 |
| signal transducer activity | 2.85730457922199 | bayes_pls_golite062009 |
| protein tyrosine kinase activity | 2.8153155526437 | bayes_pls_golite062009 |
| binding | 2.74863538127007 | bayes_pls_golite062009 |
| growth factor binding | 2.61235080252818 | bayes_pls_golite062009 |
| insulin binding | 2.37668498690029 | bayes_pls_golite062009 |
| protein binding | 2.276111749106 | bayes_pls_golite062009 |
| transmembrane receptor protein serine/threonine kinase activity | 2.1677218320705 | bayes_pls_golite062009 |
| transforming growth factor beta receptor activity | 2.1677218320705 | bayes_pls_golite062009 |
| receptor signaling protein activity | 2.10379226653669 | bayes_pls_golite062009 |
| SH2 domain binding | 2.08937039830657 | bayes_pls_golite062009 |
| ATP binding | 1.97600611746091 | bayes_pls_golite062009 |
| adenyl ribonucleotide binding | 1.93596671856664 | bayes_pls_golite062009 |
| adenyl nucleotide binding | 1.90928021591891 | bayes_pls_golite062009 |
| receptor signaling protein serine/threonine kinase activity | 1.81249386965144 | bayes_pls_golite062009 |
| acetylcholine receptor activator activity | 1.71667135325509 | bayes_pls_golite062009 |
| non-membrane spanning protein tyrosine kinase activity | 1.66669268613198 | bayes_pls_golite062009 |
| purine ribonucleotide binding | 1.65732943334212 | bayes_pls_golite062009 |
| ribonucleotide binding | 1.65726906484847 | bayes_pls_golite062009 |
| purine nucleotide binding | 1.63763394711025 | bayes_pls_golite062009 |
| nucleotide binding | 1.63195828048121 | bayes_pls_golite062009 |
| integrin binding | 1.44154155381408 | bayes_pls_golite062009 |
| PTB domain binding | 1.2635189297467 | bayes_pls_golite062009 |
| activin binding | 1.22461306010416 | bayes_pls_golite062009 |
| catalytic activity | 1.21655087018101 | bayes_pls_golite062009 |
| insulin receptor activity | 0.974517002259609 | bayes_pls_golite062009 |
| insulin receptor substrate binding | 0.95914323793919 | bayes_pls_golite062009 |
| fibroblast growth factor 1 binding | 0.881001697574359 | bayes_pls_golite062009 |
| transforming growth factor beta receptor activity, type I | 0.880236579821909 | bayes_pls_golite062009 |
| MAP kinase activity | 0.81943579965027 | bayes_pls_golite062009 |
| activin receptor activity | 0.811117252475389 | bayes_pls_golite062009 |
| fibroblast growth factor receptor activity | 0.75189004129952 | bayes_pls_golite062009 |
| transporter activity | 0.710766490066447 | bayes_pls_golite062009 |
| actin filament binding | 0.66248865719696 | bayes_pls_golite062009 |
| MAP kinase kinase activity | 0.610230065465794 | bayes_pls_golite062009 |
| transmembrane transporter activity | 0.60324822483033 | bayes_pls_golite062009 |
| cyclin-dependent protein kinase activity | 0.499492353295369 | bayes_pls_golite062009 |
| protein kinase C activity | 0.41587987561486 | bayes_pls_golite062009 |
| magnesium ion binding | 0.393328812780268 | bayes_pls_golite062009 |
| substrate-specific transporter activity | 0.385603245903806 | bayes_pls_golite062009 |
| 3-phosphoinositide-dependent protein kinase binding | 0.372842462336059 | bayes_pls_golite062009 |
| JUN kinase kinase kinase kinase activity | 0.349343975617553 | bayes_pls_golite062009 |
| glycosaminoglycan binding | 0.294256794094724 | bayes_pls_golite062009 |
| transforming growth factor beta binding | 0.287757704969289 | bayes_pls_golite062009 |
| kinase binding | 0.26752427107238 | bayes_pls_golite062009 |
| protein complex binding | 0.239339759110451 | bayes_pls_golite062009 |
| polysaccharide binding | 0.229808864843639 | bayes_pls_golite062009 |
| glutamate receptor binding | 0.208072372526169 | bayes_pls_golite062009 |
| cytokine binding | 0.17817111033393 | bayes_pls_golite062009 |
| substrate-specific transmembrane transporter activity | 0.152203945257581 | bayes_pls_golite062009 |
| activin receptor activity, type I | 0.117759584117941 | bayes_pls_golite062009 |
| protein kinase binding | 0.00674998152095019 | bayes_pls_golite062009 |
|
Region A: Residues: [1016-1096] |
1 11 21 31 41 51
| | | | | |
1 PESDGNHILD GQRGQNIFIS TDLWLEHIKM SRYCHHFKEA NLINAQQISR LTAQQLSDMG 60
61 ITLVGHQKKI LHQARQLDTI I
|
| Detection Method: | |
| Confidence: | 84.0 |
| Match: | 2qoqA |
| Description: | No description for 2qoqA was found. |
