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View Structure Prediction Details

Protein: gi|190407080
Organism: Saccharomyces cerevisiae RM11-1a
Length: 459 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|190407080.

Description E-value Query
Range		 Subject
Range
CEG1 - Alpha (guanylyltransferase) subunit of the mRNA capping enzyme, a heterodimer (the other subunit is ...
gi|207345415 - gi|207345415|gb|EDZ72243.1| YGL130Wp-like protein [Saccharomyces cerevisiae AWRI1631]
MCE1_YEAST - mRNA-capping enzyme subunit alpha OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=CEG1 P...
gi|190407080 - gi|190407080|gb|EDV10347.1| mRNA capping enzyme alpha subunit [Saccharomyces cerevisiae RM11-1a]
 0.0 [1..459] [1..459]
gi|147901021, gi... - gi|18029882|gb|AAL56552.1|AF393654_1 DNA ligase III isoform alpha [Xenopus laevis], gi|147901021|ref...
 9.0E-85 [24..448] [410..862]
DNLI1_SCHPO - DNA ligase 1 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=cdc17 PE=3 SV=1
cdc17 - ATP-dependent DNA ligase Cdc17
 6.0E-84 [5..394] [346..754]
DNLI1_ARATH - DNA ligase 1 OS=Arabidopsis thaliana GN=LIG1 PE=2 SV=2
 9.0E-83 [3..391] [372..776]
LIG1 - ligase I, DNA, ATP-dependent
 4.0E-81 [3..391] [496..900]
MCE1_MOUSE - mRNA-capping enzyme OS=Mus musculus GN=Rngtt PE=1 SV=1
 5.0E-81 [13..444] [238..597]
gi|16905197, gi|... - gi|40539108|gb|AAR87364.1| putative DNA ligase [Oryza sativa (japonica cultivar-group)], gi|37535574...
 7.0E-79 [4..391] [392..795]

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Predicted Domain #1
Region A:
Residues: [1-47] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVLAMESRVA PEIPGLIQPG NVTQDLKMMV CKLLNSPKPT KTFPGSQ

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [72-198] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DGLRVLMFIV INPVTGEQGC FMIDRENNYY LVNGFRFPRL PQKKKEELLE TLQDGTLLDG  60
   61 ELVIQTNPMT KLQELRYLMF DCLAINGRCL TQSPTSSRLA HLGKEFFKPY FDLRAAYPNR 120
  121 CTTFPFK

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 149.218487
Match: 1ckmA_
Description: RNA guanylyltransferase (mRNA capping enzyme); RNA guanylyltransferase (mRNA capping enzyme), N-terminal domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
mRNA guanylyltransferase activity 8.90512192081791 bayes_pls_golite062009
RNA guanylyltransferase activity 8.46124967325993 bayes_pls_golite062009
ligase activity, forming phosphoric ester bonds 2.90848936326491 bayes_pls_golite062009
DNA ligase activity 2.88630907730339 bayes_pls_golite062009
nucleic acid binding 2.49304224824605 bayes_pls_golite062009
ligase activity 2.44151794329612 bayes_pls_golite062009
RNA binding 2.41160981373213 bayes_pls_golite062009
DNA binding 2.3408239279957 bayes_pls_golite062009
catalytic activity 2.15370807854636 bayes_pls_golite062009
transcription regulator activity 2.10110937001387 bayes_pls_golite062009
sequence-specific DNA binding 1.9581702424972 bayes_pls_golite062009
binding 1.82998145778732 bayes_pls_golite062009
structure-specific DNA binding 1.81524862921454 bayes_pls_golite062009
guanylyltransferase activity 1.64088197294498 bayes_pls_golite062009
single-stranded DNA binding 1.62996999055328 bayes_pls_golite062009
1.5765009871268 bayes_pls_golite062009
structural constituent of ribosome 1.51215866188241 bayes_pls_golite062009
protein binding 1.38006517521813 bayes_pls_golite062009
transcription activator activity 1.24141936405635 bayes_pls_golite062009
ribonuclease activity 1.19236946227657 bayes_pls_golite062009
structural molecule activity 1.16496993393687 bayes_pls_golite062009
exoribonuclease activity, producing 5'-phosphomonoesters 1.15212468568198 bayes_pls_golite062009
transcription factor activity 1.14242112812892 bayes_pls_golite062009
exoribonuclease activity 1.10445667068538 bayes_pls_golite062009
DNA ligase (ATP) activity 1.02324195596817 bayes_pls_golite062009
3'-5'-exoribonuclease activity 0.83268201349295 bayes_pls_golite062009
DNA ligase (NAD+) activity 0.802565778478831 bayes_pls_golite062009
RNA polymerase II transcription factor activity 0.583085644017496 bayes_pls_golite062009
nuclease activity 0.57381531077345 bayes_pls_golite062009
translation regulator activity 0.515576958825022 bayes_pls_golite062009
RNA polymerase activity 0.510809870824979 bayes_pls_golite062009
DNA-directed RNA polymerase activity 0.510809870824979 bayes_pls_golite062009
translation factor activity, nucleic acid binding 0.468402630523277 bayes_pls_golite062009
mRNA binding 0.4162128308402 bayes_pls_golite062009
translation initiation factor activity 0.2080607201312 bayes_pls_golite062009
chromatin binding 0.19409870825073 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [48-71] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PVSFQHSDVE EKLLAHDYYV CEKT

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [199-253] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ISMKHMDFSY QLVKVAKSLD KLPHLSDGLI FTPVKAPYTA GGKDSLLLKW KPEQE

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 149.218487
Match: 1ckmA_
Description: RNA guanylyltransferase (mRNA capping enzyme); RNA guanylyltransferase (mRNA capping enzyme), N-terminal domain
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [254-338] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NTVDFKLILD IPMVEDPSLP KDDRNRWYYN YDVKPVFSLY VWQGGADVNS RLKHFDQPFD  60
   61 RKEFEILERT YRKFAELSVS DEEWQ

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 149.218487
Match: 1ckmA_
Description: RNA guanylyltransferase (mRNA capping enzyme); RNA guanylyltransferase (mRNA capping enzyme), N-terminal domain
Matching Structure (courtesy of the PDB):

Predicted Domain #4
Region A:
Residues: [339-459] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NLKNLEQPLN GRIVECAKNQ ETGAWEMLRF RDDKLNGNHT SVVQKVLESI NDSVSLEDLE  60
   61 EIVGDIKRCW DERRANMAGG SGRPLPSQSQ NATLSTSKPV HSQPPSNDKE PKYVDEDDWS 120
  121 D

[Run NCBI BLAST on this sequence.]

Detection Method: ORFEUS
Confidence: 10.46
Match: 1ckmA
Description: RNA guanylyltransferase (mRNA capping enzyme); RNA guanylyltransferase (mRNA capping enzyme), N-terminal domain
Matching Structure (courtesy of the PDB):
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle