YRC Public Data Repository - Protein Structure Prediction

Protein:	gi\|11513338, gi\|...
Organism:	Homo sapiens
Length:	141 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|11513338, gi|....

Description	E-value	Query Range	Subject Range
gi\|73948993 - gi\|73948993\|ref\|XP_535176.2\| PREDICTED: similar to S-phase kinase-associated protein 1A isoform b [C...	216.0	[0..1]	[141..82]
gi\|146387063, gi... - gi\|146387063\|pdb\|2OVR\|A Chain A, Structure Of The Skp1-Fbw7-Cyclinedegn Complex, gi\|146387060\|pdb\|2O...	209.0	[0..1]	[141..1]
gi\|29841010 - gi\|29841010\|gb\|AAP06023.1\| SJCHGC06138 protein [Schistosoma japonicum]	204.0	[0..1]	[140..1]
gi\|26347143, gi\|... - gi\|31560543\|ref\|NP_035673.2\| S-phase kinase-associated protein 1A [Mus musculus], gi\|26347143\|dbj\|BA...	203.0	[0..1]	[141..1]
gi\|114601681, gi... - gi\|114601685\|ref\|XP_001166324.1\| PREDICTED: similar to OCP-II protein isoform 8 [Pan troglodytes], g...	203.0	[0..1]	[141..12]
gi\|221221226, gi... - gi\|221221806\|gb\|ACM09564.1\| S-phase kinase-associated protein 1 [Salmo salar], gi\|221221226\|gb\|ACM09... gi\|225704136, gi... - gi\|225704136\|gb\|ACO07914.1\| S-phase kinase-associated protein 1A [Oncorhynchus mykiss], gi\|225703580... SKP1_RAT - S-phase kinase-associated protein 1 OS=Rattus norvegicus GN=Skp1 PE=1 SV=3 gi\|229367476 - gi\|229367476\|gb\|ACQ58718.1\| S-phase kinase-associated protein 1 [Anoplopoma fimbria] SKP1_MOUSE - S-phase kinase-associated protein 1 OS=Mus musculus GN=Skp1 PE=1 SV=3	203.0	[0..1]	[141..1]

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Predicted Domain #1

Region A:
Residues: [1-141]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPSIKLQSSD GEIFEVDVEI AKQSVTIKTM LEDLGMDPVP LPNVNAAILK KVIQWCTHHK  60
   61 DDPPPPEDDE NKEKRTDDIP VWDQEFLKVD QGTLFELILA ANYLDIKGLL DVTCKTVANM 120
  121 IKGKTPEEIR KTFNIKNDFT E

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	55.154902
Match:	1fs1B
Description:	Cyclin A/CDK2-associated p45, Skp1
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
ubiquitin-protein ligase activity	6.78934422958647	bayes_pls_golite062009
small conjugating protein ligase activity	6.52079977531395	bayes_pls_golite062009
acid-amino acid ligase activity	5.78412146341235	bayes_pls_golite062009
ligase activity, forming carbon-nitrogen bonds	4.95822114853319	bayes_pls_golite062009
voltage-gated cation channel activity	2.77401933213311	bayes_pls_golite062009
transporter activity	2.7339908225983	bayes_pls_golite062009
binding	2.73171412378045	bayes_pls_golite062009
cation channel activity	2.71768147195598	bayes_pls_golite062009
transcription regulator activity	2.69230674138567	bayes_pls_golite062009
voltage-gated potassium channel activity	2.65490556751361	bayes_pls_golite062009
voltage-gated ion channel activity	2.64938600384117	bayes_pls_golite062009
voltage-gated channel activity	2.64838408752747	bayes_pls_golite062009
potassium channel activity	2.62652737979087	bayes_pls_golite062009
transmembrane transporter activity	2.61347075279737	bayes_pls_golite062009
substrate-specific transporter activity	2.58329333159441	bayes_pls_golite062009
gated channel activity	2.57592710439337	bayes_pls_golite062009
ion channel activity	2.574752452969	bayes_pls_golite062009
cation transmembrane transporter activity	2.54922823284862	bayes_pls_golite062009
substrate-specific channel activity	2.51918375917065	bayes_pls_golite062009
channel activity	2.5028491309185	bayes_pls_golite062009
passive transmembrane transporter activity	2.5028491309185	bayes_pls_golite062009
ion transmembrane transporter activity	2.50017243561816	bayes_pls_golite062009
substrate-specific transmembrane transporter activity	2.49050794760122	bayes_pls_golite062009
protein binding	2.43603601331034	bayes_pls_golite062009
metal ion transmembrane transporter activity	2.38629208611427	bayes_pls_golite062009
nucleic acid binding	2.37599621599404	bayes_pls_golite062009
DNA binding	2.35465234368027	bayes_pls_golite062009
transcription repressor activity	1.8778052324763	bayes_pls_golite062009
ligase activity	1.75579073151181	bayes_pls_golite062009
transcription factor activity	1.69643994786795	bayes_pls_golite062009
monovalent inorganic cation transmembrane transporter activity	1.55472700872528	bayes_pls_golite062009
structure-specific DNA binding	0.784594789263781	bayes_pls_golite062009
delayed rectifier potassium channel activity	0.744657282641449	bayes_pls_golite062009
DNA replication origin binding	0.59693484482914	bayes_pls_golite062009
sequence-specific DNA binding	0.246870129899812	bayes_pls_golite062009
catalytic activity	0.112500532859479	bayes_pls_golite062009
double-stranded DNA binding	0.033499769837058	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: