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View Protein Complex Details

Complex Overview

From Publication: Ho Y. et al. (2002) Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry. Nature. 2002 Jan 10;415(6868):180-3.
Notes: This molecular complex record represents a population of complexes co-purified by immunoprecipitation of FLAG-tagged Yck1. The topolgies of protein complexes in this experiment are unknown.
Complex Size: 7 proteins

Complex Member Proteins

Protein

GO Cellular Component GO Biological Process GO Molecular Function
PDC5
  • nucleus
  • cytoplasm
  • cytosol
  • pyruvate metabolic process
  • glucose catabolic process to ethanol
  • pyruvate decarboxylase activity
  • PPH21
  • protein phosphatase type 2A complex
  • mitotic cell cycle spindle assembly checkpoint
  • G1/S transition of mitotic cell cycle
  • protein amino acid dephosphorylation
  • actin filament organization
  • budding cell bud growth
  • translation
  • protein serine/threonine phosphatase activity
  • phosphoprotein phosphatase activity
  • metal ion binding
  • hydrolase activity
  • PPH22
  • condensed nuclear chromosome, centromeric region
  • protein phosphatase type 2A complex
  • mitotic cell cycle spindle assembly checkpoint
  • G1/S transition of mitotic cell cycle
  • protein amino acid dephosphorylation
  • actin filament organization
  • budding cell bud growth
  • translation
  • protein serine/threonine phosphatase activity
  • phosphoprotein phosphatase activity
  • metal ion binding
  • hydrolase activity
  • THI21
  • cellular_component
  • thiamin biosynthetic process
  • hydroxymethylpyrimidine kinase activity
  • phosphomethylpyrimidine kinase activity
  • TPD3
  • nucleus
  • cellular bud tip
  • cytoplasm
  • cellular bud neck
  • spindle pole body
  • mating projection tip
  • protein phosphatase type 2A complex
  • mitotic cell cycle spindle assembly checkpoint
  • protein amino acid dephosphorylation
  • actin filament organization
  • budding cell bud growth
  • translation
  • YCK1
  • mitochondrion
  • endoplasmic reticulum
  • plasma membrane
  • response to glucose stimulus
  • cell morphogenesis
  • cytokinesis
  • protein amino acid phosphorylation
  • endocytosis
  • casein kinase I activity
  • YCK2
  • cellular bud neck
  • mating projection
  • plasma membrane
  • response to glucose stimulus
  • cell morphogenesis
  • cytokinesis
  • protein amino acid phosphorylation
  • endocytosis
  • casein kinase I activity
  • Cellular Component Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    protein phosphatase type 2A complex 1.6845E-8 7 6 3 6292
    protein serine/threonine phosphatase complex 5.6973E-7 7 17 3 6292
    cell projection 1.2171E-3 7 49 2 6292
    mating projection 1.2171E-3 7 49 2 6292
    cellular bud neck 8.188E-3 7 129 2 6292

    Biological Process Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    cell division 1.2282E-7 7 145 5 6292
    mitotic cell cycle spindle assembly checkpoint 1.1122E-6 7 21 3 6292
    negative regulation of nuclear division 1.1122E-6 7 21 3 6292
    negative regulation of mitosis 1.1122E-6 7 21 3 6292
    negative regulation of mitotic metaphase/anaphase transition 1.1122E-6 7 21 3 6292
    spindle assembly checkpoint 1.1122E-6 7 21 3 6292
    phosphorus metabolic process 1.2103E-6 7 229 5 6292
    phosphate metabolic process 1.2103E-6 7 229 5 6292
    negative regulation of cell cycle 1.2872E-6 7 22 3 6292
    spindle checkpoint 1.9197E-6 7 25 3 6292
    regulation of mitotic metaphase/anaphase transition 1.9197E-6 7 25 3 6292
    mitotic cell cycle spindle checkpoint 1.9197E-6 7 25 3 6292
    mitotic cell cycle checkpoint 2.7303E-6 7 28 3 6292
    protein amino acid dephosphorylation 2.7303E-6 7 28 3 6292
    negative regulation of cellular component organization 3.0439E-6 7 29 3 6292
    regulation of nuclear division 3.0439E-6 7 29 3 6292
    negative regulation of organelle organization 3.0439E-6 7 29 3 6292
    regulation of mitosis 3.0439E-6 7 29 3 6292
    negative regulation of cell cycle process 4.126E-6 7 32 3 6292
    budding cell bud growth 4.973E-6 7 34 3 6292
    mitotic metaphase/anaphase transition 6.448E-6 7 37 3 6292
    dephosphorylation 8.1872E-6 7 40 3 6292
    response to monosaccharide stimulus 1.0594E-5 7 5 2 6292
    response to glucose stimulus 1.0594E-5 7 5 2 6292
    response to hexose stimulus 1.0594E-5 7 5 2 6292
    post-translational protein modification 1.093E-5 7 357 5 6292
    response to carbohydrate stimulus 1.5882E-5 7 6 2 6292
    regulation of organelle organization 1.8209E-5 7 52 3 6292
    cell cycle checkpoint 2.535E-5 7 58 3 6292
    actin filament organization 4.0976E-5 7 68 3 6292
    regulation of mitotic cell cycle 4.6664E-5 7 71 3 6292
    regulation of cellular component organization 5.5024E-5 7 75 3 6292
    protein modification process 5.649E-5 7 499 5 6292
    regulation of cell cycle process 6.9325E-5 7 81 3 6292
    cell budding 9.5043E-5 7 90 3 6292
    asexual reproduction 9.5043E-5 7 90 3 6292
    macromolecule modification 1.0702E-4 7 569 5 6292
    mitosis 1.4634E-4 7 104 3 6292
    nuclear division 1.5488E-4 7 106 3 6292
    organelle fission 1.8733E-4 7 113 3 6292
    actin cytoskeleton organization 1.8733E-4 7 113 3 6292
    actin filament-based process 2.0773E-4 7 117 3 6292
    M phase of mitotic cell cycle 2.7117E-4 7 128 3 6292
    regulation of cell cycle 2.9042E-4 7 131 3 6292
    growth 3.9206E-4 7 145 3 6292
    signal transduction 1.2271E-3 7 214 3 6292
    G1/S transition of mitotic cell cycle 1.2671E-3 7 50 2 6292
    signal transmission 1.2778E-3 7 217 3 6292
    signaling process 1.2778E-3 7 217 3 6292
    reproduction of a single-celled organism 1.2778E-3 7 217 3 6292
    cytoskeleton organization 1.5322E-3 7 231 3 6292
    negative regulation of cellular process 1.9262E-3 7 250 3 6292
    signaling 1.9711E-3 7 252 3 6292
    negative regulation of biological process 1.9938E-3 7 253 3 6292
    mitotic cell cycle 2.0396E-3 7 255 3 6292
    cellular protein metabolic process 2.2261E-3 7 1074 5 6292
    protein metabolic process 2.8929E-3 7 1136 5 6292
    M phase 3.0716E-3 7 294 3 6292
    endocytosis 3.8803E-3 7 88 2 6292
    reproduction 4.199E-3 7 328 3 6292
    membrane invagination 4.4166E-3 7 94 2 6292
    interphase of mitotic cell cycle 4.6971E-3 7 97 2 6292
    interphase 4.6971E-3 7 97 2 6292
    protein amino acid phosphorylation 5.2825E-3 7 103 2 6292
    cellular metabolic process 6.026E-3 7 3033 7 6292
    cell cycle phase 6.1847E-3 7 376 3 6292
    translation 6.1847E-3 7 376 3 6292
    cytokinesis 6.2209E-3 7 112 2 6292
    cell morphogenesis 7.7026E-3 7 125 2 6292
    glucose catabolic process to ethanol 7.7654E-3 7 7 1 6292
    metabolic process 7.9792E-3 7 3157 7 6292
    glycolytic fermentation 8.8705E-3 7 8 1 6292
    response to organic substance 9.1999E-3 7 137 2 6292
    cellular component morphogenesis 9.3302E-3 7 138 2 6292

    Molecular Function Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    casein kinase I activity 6.3596E-6 7 4 2 6292
    protein serine/threonine phosphatase activity 3.4048E-4 7 26 2 6292
    phosphoprotein phosphatase activity 9.3752E-4 7 43 2 6292
    metal ion binding 1.532E-3 7 55 2 6292
    ion binding 1.5879E-3 7 56 2 6292
    cation binding 1.5879E-3 7 56 2 6292
    hydroxymethylpyrimidine kinase activity 2.224E-3 7 2 1 6292
    obsolete_molecular_function 2.4022E-3 7 69 2 6292
    phosphomethylpyrimidine kinase activity 3.3344E-3 7 3 1 6292
    phosphatase activity 3.7942E-3 7 87 2 6292
    pyruvate decarboxylase activity 4.4437E-3 7 4 1 6292
    phosphoric ester hydrolase activity 5.1826E-3 7 102 2 6292

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