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View Protein Complex Details

Complex Overview

From Publication: Ho Y. et al. (2002) Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry. Nature. 2002 Jan 10;415(6868):180-3.
Notes: This molecular complex record represents a population of complexes co-purified by immunoprecipitation of FLAG-tagged Dnl4. The topolgies of protein complexes in this experiment are unknown.
Complex Size: 15 proteins

Complex Member Proteins

Protein

GO Cellular Component GO Biological Process GO Molecular Function
ACO1
  • mitochondrial matrix
  • mitochondrion
  • cytosol
  • mitochondrial nucleoid
  • glutamate biosynthetic process
  • response to drug
  • citrate metabolic process
  • propionate metabolic process
  • tricarboxylic acid cycle
  • mitochondrial genome maintenance
  • aconitate hydratase activity
  • CIC1
  • proteasome complex
  • nucleolus
  • protein catabolic process
  • ribosomal large subunit biogenesis
  • ribosome biogenesis
  • protein binding, bridging
  • DNL4
  • nucleus
  • double-strand break repair via nonhomologous end joining
  • DNA ligase (ATP) activity
  • GDE1
  • cytoplasm
  • ribosome
  • glycerophospholipid catabolic process
  • glycerophosphocholine phosphodiesterase activity
  • HTA1
  • nuclear nucleosome
  • DNA repair
  • chromatin assembly or disassembly
  • DNA binding
  • KGD1
  • mitochondrial matrix
  • mitochondrial oxoglutarate dehydrogenase complex
  • mitochondrion
  • mitochondrial nucleoid
  • tricarboxylic acid cycle
  • 2-oxoglutarate metabolic process
  • oxoglutarate dehydrogenase (succinyl-transferring) activity
  • MAK16
  • nucleolus
  • ribosomal large subunit biogenesis
  • ribosome biogenesis
  • processing of 27S pre-rRNA
  • molecular_function
  • NOP15
  • nucleus
  • nucleolus
  • cytokinesis, actomyosin contractile ring assembly
  • ribosomal large subunit biogenesis
  • ribosome biogenesis
  • ribosome assembly
  • molecular_function
  • NOP2
  • nucleolus
  • ribosome biogenesis
  • rRNA processing
  • RNA methyltransferase activity
  • S-adenosylmethionine-dependent methyltransferase activity
  • NOP7
  • nucleus
  • nucleolus
  • cell proliferation
  • maturation of SSU-rRNA
  • ribosomal large subunit biogenesis
  • ribosome biogenesis
  • cell cycle
  • molecular_function
  • NSA1
  • nucleus
  • nucleolus
  • ribosomal large subunit biogenesis
  • ribosome biogenesis
  • molecular_function
  • RPF2
  • nucleolus
  • ribosome biogenesis
  • ribosomal large subunit assembly
  • processing of 27S pre-rRNA
  • 5S rRNA binding
  • 7S RNA binding
  • rRNA binding
  • RRT6
  • membrane
  • biological_process
  • molecular_function
  • TIF6
  • nucleus
  • cytoplasm
  • nuclear outer membrane
  • nucleolus
  • ribosomal subunit export from nucleus
  • ribosomal large subunit biogenesis
  • processing of 27S pre-rRNA
  • ribosomal large subunit binding
  • YTM1
  • nucleus
  • nucleolus
  • ribosomal large subunit biogenesis
  • ribosome biogenesis
  • molecular_function
  • Cellular Component Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    nucleolus 1.9043E-10 15 211 9 6292
    non-membrane-bounded organelle 1.7363E-9 15 959 13 6292
    intracellular non-membrane-bounded organelle 1.7363E-9 15 959 13 6292
    organelle lumen 1.4393E-8 15 660 11 6292
    intracellular organelle lumen 1.4393E-8 15 660 11 6292
    membrane-enclosed lumen 2.6923E-8 15 700 11 6292
    nuclear lumen 1.6291E-7 15 453 9 6292
    nuclear part 3.3734E-5 15 1103 10 6292
    intracellular organelle part 6.8752E-4 15 2282 12 6292
    organelle part 6.8752E-4 15 2282 12 6292
    nucleus 1.3856E-3 15 2041 11 6292
    nucleoid 1.6681E-3 15 26 2 6292
    mitochondrial nucleoid 1.6681E-3 15 26 2 6292
    mitochondrial oxoglutarate dehydrogenase complex 7.136E-3 15 3 1 6292
    oxoglutarate dehydrogenase complex 7.136E-3 15 3 1 6292

    Biological Process Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    ribosomal large subunit biogenesis 5.0599E-13 15 65 8 6292
    ribosome biogenesis 1.5492E-8 15 346 9 6292
    ribonucleoprotein complex biogenesis 3.0671E-8 15 374 9 6292
    processing of 27S pre-rRNA 6.027E-6 15 16 3 6292
    cellular component biogenesis 6.2228E-6 15 694 9 6292
    obsolete_biological_process 3.4578E-4 15 60 3 6292
    acetyl-CoA catabolic process 5.4716E-4 15 15 2 6292
    tricarboxylic acid cycle 5.4716E-4 15 15 2 6292
    acetyl-CoA metabolic process 9.8331E-4 15 20 2 6292
    coenzyme catabolic process 9.8331E-4 15 20 2 6292
    cofactor catabolic process 1.1922E-3 15 22 2 6292
    2-oxoglutarate metabolic process 4.7627E-3 15 2 1 6292
    phospholipid catabolic process 7.136E-3 15 3 1 6292
    glycerophospholipid catabolic process 7.136E-3 15 3 1 6292
    actomyosin structure organization 7.136E-3 15 3 1 6292
    cytokinesis, actomyosin contractile ring assembly 7.136E-3 15 3 1 6292
    assembly of actomyosin apparatus involved in cell cycle cytokinesis 7.136E-3 15 3 1 6292
    citrate metabolic process 9.5041E-3 15 4 1 6292
    ribosome assembly 9.8206E-3 15 64 2 6292

    Molecular Function Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    ribosomal large subunit binding 2.384E-3 15 1 1 6292
    7S RNA binding 2.384E-3 15 1 1 6292
    glycerophosphocholine phosphodiesterase activity 2.384E-3 15 1 1 6292
    aconitate hydratase activity 4.7627E-3 15 2 1 6292
    DNA ligase activity 4.7627E-3 15 2 1 6292
    oxoglutarate dehydrogenase (succinyl-transferring) activity 4.7627E-3 15 2 1 6292
    5S rRNA binding 4.7627E-3 15 2 1 6292
    DNA ligase (ATP) activity 4.7627E-3 15 2 1 6292
    ligase activity, forming phosphoric ester bonds 9.5041E-3 15 4 1 6292

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle