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View Protein Complex Details

Complex Overview

From Publication: Krogan N. J. et al. (2006) Global landscape of protein complexes in the yeast Saccharomyces cerevisiae. Nature. 2006 Mar 30;440(7084):637-43. Epub 2006 Mar 22.
Notes: From the published set of core protein complex predictions.
Complex Size: 15 proteins

Complex Member Proteins

Protein

GO Cellular Component GO Biological Process GO Molecular Function
AME1
  • COMA complex
  • spindle pole body
  • kinetochore
  • attachment of spindle microtubules to kinetochore
  • molecular_function
  • ARG5,6
  • mitochondrial matrix
  • mitochondrion
  • arginine biosynthetic process
  • ornithine biosynthetic process
  • regulation of transcription
  • N-acetyl-gamma-glutamyl-phosphate reductase activity
  • acetylglutamate kinase activity
  • CHL4
  • outer kinetochore of condensed nuclear chromosome
  • chromosome segregation
  • DNA binding
  • CTF19
  • nucleus
  • COMA complex
  • condensed nuclear chromosome kinetochore
  • attachment of spindle microtubules to kinetochore
  • chromosome segregation
  • protein binding
  • CTF3
  • condensed nuclear chromosome kinetochore
  • chromosome segregation
  • protein binding
  • IML3
  • outer kinetochore of condensed nuclear chromosome
  • ascospore formation
  • meiotic sister chromatid segregation
  • chromosome segregation
  • molecular_function
  • MCM16
  • condensed nuclear chromosome kinetochore
  • chromosome segregation
  • protein binding
  • MCM21
  • COMA complex
  • condensed nuclear chromosome kinetochore
  • chromosome segregation
  • protein binding
  • MCM22
  • condensed nuclear chromosome kinetochore
  • chromosome segregation
  • protein binding
  • NKP1
  • kinetochore
  • biological_process
  • molecular_function
  • NKP2
  • spindle pole body
  • kinetochore
  • biological_process
  • molecular_function
  • OKP1
  • COMA complex
  • condensed nuclear chromosome kinetochore
  • chromosome segregation
  • protein binding
  • PRP18
  • U4/U6 x U5 tri-snRNP complex
  • spliceosomal complex
  • generation of catalytic spliceosome for second transesterification step
  • nuclear mRNA splicing, via spliceosome
  • second spliceosomal transesterification activity
  • SET4
  • cellular_component
  • biological_process
  • molecular_function
  • YNR062C
  • integral to membrane
  • biological_process
  • molecular_function
  • Cellular Component Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    kinetochore 2.9913E-20 15 60 11 6292
    chromosome, centromeric region 1.1171E-19 15 67 11 6292
    condensed nuclear chromosome kinetochore 2.3457E-16 15 49 9 6292
    condensed chromosome kinetochore 2.3457E-16 15 49 9 6292
    condensed chromosome, centromeric region 7.2223E-16 15 55 9 6292
    condensed nuclear chromosome, centromeric region 7.2223E-16 15 55 9 6292
    condensed nuclear chromosome 5.0848E-14 15 86 9 6292
    condensed chromosome 1.168E-13 15 94 9 6292
    chromosomal part 2.0603E-13 15 237 11 6292
    chromosome 1.0262E-12 15 274 11 6292
    nuclear chromosome part 7.4063E-11 15 190 9 6292
    COMA complex 1.0446E-10 15 5 4 6292
    nuclear chromosome 3.8172E-10 15 228 9 6292
    non-membrane-bounded organelle 7.3959E-7 15 959 11 6292
    intracellular non-membrane-bounded organelle 7.3959E-7 15 959 11 6292
    protein complex 4.2986E-6 15 1137 11 6292
    outer kinetochore of condensed nuclear chromosome 5.3053E-6 15 2 2 6292
    outer kinetochore of condensed chromosome 5.3053E-6 15 2 2 6292
    macromolecular complex 1.8508E-5 15 1635 12 6292
    nuclear part 3.3734E-5 15 1103 10 6292
    intracellular organelle part 8.5313E-5 15 2282 13 6292
    organelle part 8.5313E-5 15 2282 13 6292
    nucleus 6.7962E-3 15 2041 10 6292
    microtubule organizing center 9.5268E-3 15 63 2 6292
    spindle pole body 9.5268E-3 15 63 2 6292

    Biological Process Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    chromosome segregation 2.0321E-12 15 128 9 6292
    microtubule anchoring 1.5894E-5 15 3 2 6292
    attachment of spindle microtubules to chromosome 1.5894E-5 15 3 2 6292
    attachment of spindle microtubules to kinetochore 1.5894E-5 15 3 2 6292
    maintenance of protein location in cell 1.5419E-3 15 25 2 6292
    maintenance of protein location 1.6681E-3 15 26 2 6292
    maintenance of location in cell 1.7991E-3 15 27 2 6292
    maintenance of location 1.9348E-3 15 28 2 6292
    meiosis II 9.5041E-3 15 4 1 6292
    meiotic sister chromatid segregation 9.5041E-3 15 4 1 6292
    ornithine biosynthetic process 9.5041E-3 15 4 1 6292

    Molecular Function Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    protein binding 1.9186E-3 15 612 6 6292
    acetylglutamate kinase activity 2.384E-3 15 1 1 6292
    N-acetyl-gamma-glutamyl-phosphate reductase activity 2.384E-3 15 1 1 6292

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    Created and Maintained by: Michael Riffle