YRC Public Data Repository - Protein Complex GO Analysis

Complex Overview

From Publication:	Krogan N. J. et al. (2006) Global landscape of protein complexes in the yeast Saccharomyces cerevisiae. Nature. 2006 Mar 30;440(7084):637-43. Epub 2006 Mar 22.
Notes:	From the published set of core protein complex predictions.
Complex Size:	27 proteins

Complex Member Proteins

Protein	GO Cellular Component	GO Biological Process	GO Molecular Function
CSE2	nucleus mediator complex	mitotic sister chromatid segregation transcription from RNA polymerase II promoter	RNA polymerase II transcription mediator activity
DSS1	mitochondrial matrix mitochondrion	RNA catabolic process	exoribonuclease II activity
GAL11	nucleus mediator complex	telomere maintenance transcription from RNA polymerase II promoter	RNA polymerase II transcription mediator activity
GPT2	cytoplasm endoplasmic reticulum	phospholipid biosynthetic process	glycerol-3-phosphate O-acyltransferase activity
IRC11
MED1	nucleus mediator complex	telomere maintenance transcription from RNA polymerase II promoter	RNA polymerase II transcription mediator activity
MED11	mediator complex	transcription from RNA polymerase II promoter	structural molecule activity RNA polymerase II transcription mediator activity
MED2	nucleus mediator complex	transcription from RNA polymerase II promoter	RNA polymerase II transcription mediator activity
MED4	nucleus mediator complex	transcription from RNA polymerase II promoter	RNA polymerase II transcription mediator activity
MED6	mediator complex	transcription from RNA polymerase II promoter	RNA polymerase II transcription mediator activity
MED7	nucleus mediator complex	transcription from RNA polymerase II promoter	RNA polymerase II transcription mediator activity
MED8	mediator complex	transcription from RNA polymerase II promoter	RNA polymerase II transcription mediator activity
NUT1	nucleus mitochondrion	regulation of transcription from RNA polymerase II promoter	molecular_function
NUT2	nucleus mediator complex	transcription from RNA polymerase II promoter	RNA polymerase II transcription mediator activity
PGD1	nucleus mediator complex	response to drug telomere maintenance transcription from RNA polymerase II promoter	RNA polymerase II transcription mediator activity
RGR1	nucleus mediator complex	transcription from RNA polymerase II promoter	RNA polymerase II transcription mediator activity
ROX3	nucleus	transcription from RNA polymerase II promoter	RNA polymerase II transcription mediator activity
SIN4	nucleus mediator complex	transcription from RNA polymerase II promoter	RNA polymerase II transcription mediator activity
SOH1	nucleus	DNA repair telomere maintenance transcription from RNA polymerase II promoter	molecular_function
SRB2	mediator complex	telomere maintenance transcription from RNA polymerase II promoter	RNA polymerase II transcription mediator activity
SRB4	mediator complex	transcription from RNA polymerase II promoter	RNA polymerase II transcription mediator activity
SRB5	mediator complex	telomere maintenance transcription from RNA polymerase II promoter	RNA polymerase II transcription mediator activity
SRB6	mediator complex	transcription from RNA polymerase II promoter	structural molecule activity RNA polymerase II transcription mediator activity
SRB7	nucleus mediator complex	transcription from RNA polymerase II promoter	RNA polymerase II transcription mediator activity
SSN3	transcription factor complex	negative regulation of transcription from RNA polymerase II promoter telomere maintenance protein amino acid phosphorylation regulation of transcription meiosis	general RNA polymerase II transcription factor activity cyclin-dependent protein kinase activity
SSN8	transcription factor complex	negative regulation of transcription from RNA polymerase II promoter telomere maintenance meiosis	cyclin-dependent protein kinase regulator activity general RNA polymerase II transcription factor activity
THI72	membrane	transport thiamin transport	transporter activity

Cellular Component Analysis

Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

Only showing terms with a p-value less than or equal to 0.01.

GO Term	P-value	A	B	I	T
mediator complex	1.287E-46	27	18	18	6292
nucleoplasm part	2.0763E-23	27	245	20	6292
nucleoplasm	9.6052E-23	27	264	20	6292
nuclear lumen	5.202E-18	27	453	20	6292
organelle lumen	3.2768E-16	27	660	21	6292
intracellular organelle lumen	3.2768E-16	27	660	21	6292
membrane-enclosed lumen	1.1029E-15	27	700	21	6292
nuclear part	1.6459E-10	27	1103	20	6292
protein complex	2.9079E-10	27	1137	20	6292
nucleus	2.0986E-8	27	2041	23	6292
macromolecular complex	2.2491E-7	27	1635	20	6292
organelle part	1.2589E-5	27	2282	21	6292
intracellular organelle part	1.2589E-5	27	2282	21	6292
membrane-bounded organelle	1.7041E-4	27	3771	25	6292
intracellular membrane-bounded organelle	1.7041E-4	27	3771	25	6292
intracellular organelle	9.2018E-4	27	4070	25	6292
organelle	9.2512E-4	27	4071	25	6292

Biological Process Analysis

Only showing terms with a p-value less than or equal to 0.01.

GO Term	P-value	A	B	I	T
transcription from RNA polymerase II promoter	3.5088E-26	27	335	23	6292
transcription, DNA-dependent	4.6937E-22	27	503	23	6292
RNA biosynthetic process	5.9034E-22	27	508	23	6292
transcription	4.0357E-21	27	552	23	6292
RNA metabolic process	3.1374E-17	27	954	24	6292
cellular macromolecule biosynthetic process	1.4743E-13	27	1187	23	6292
macromolecule biosynthetic process	1.5307E-13	27	1189	23	6292
nucleic acid metabolic process	3.4292E-13	27	1415	24	6292
gene expression	8.3402E-13	27	1283	23	6292
nucleobase, nucleoside, nucleotide and nucleic acid metabolic process	3.6431E-12	27	1566	24	6292
cellular biosynthetic process	3.6976E-12	27	1567	24	6292
biosynthetic process	6.1756E-12	27	1602	24	6292
cellular nitrogen compound metabolic process	6.2E-11	27	1770	24	6292
nitrogen compound metabolic process	8.1358E-11	27	1791	24	6292
cellular macromolecule metabolic process	2.0967E-8	27	2285	24	6292
macromolecule metabolic process	3.9018E-8	27	2349	24	6292
primary metabolic process	3.9096E-7	27	2896	25	6292
cellular metabolic process	1.1557E-6	27	3033	25	6292
metabolic process	2.9404E-6	27	3157	25	6292
anatomical structure homeostasis	1.7226E-5	27	286	8	6292
telomere organization	1.7226E-5	27	286	8	6292
telomere maintenance	1.7226E-5	27	286	8	6292
homeostatic process	2.1656E-4	27	408	8	6292
chromosome organization	3.3292E-4	27	555	9	6292
regulation of biological quality	1.628E-3	27	551	8	6292
DNA metabolic process	2.3925E-3	27	585	8	6292
cellular process	5.5321E-3	27	4426	25	6292

Molecular Function Analysis

Only showing terms with a p-value less than or equal to 0.01.

GO Term	P-value	A	B	I	T
RNA polymerase II transcription mediator activity	2.8329E-46	27	22	19	6292
general RNA polymerase II transcription factor activity	1.0385E-38	27	64	21	6292
RNA polymerase II transcription factor activity	2.0836E-31	27	130	21	6292
transcription regulator activity	2.7639E-22	27	339	21	6292
exoribonuclease II activity	4.2912E-3	27	1	1	6292
glycerol-3-phosphate O-acyltransferase activity	8.5646E-3	27	2	1	6292

View Protein Complex Details

Complex Overview

Complex Member Proteins

Cellular Component Analysis

Biological Process Analysis

Molecular Function Analysis