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View Protein Complex Details

Complex Overview

From Publication: Riffle <i>et al</i>. (2010) (Unpublished Data)
Notes: Complex predicted from the combined set of Gavin (2002), Gavin (2006), Ho (2002) and Krogan (2006); at p-value cutoff of 1E-7
Complex Size: 21 proteins

Complex Member Proteins

Protein

GO Cellular Component GO Biological Process GO Molecular Function
CSE2
  • nucleus
  • mediator complex
  • mitotic sister chromatid segregation
  • transcription from RNA polymerase II promoter
  • RNA polymerase II transcription mediator activity
  • GAL11
  • nucleus
  • mediator complex
  • telomere maintenance
  • transcription from RNA polymerase II promoter
  • RNA polymerase II transcription mediator activity
  • MED1
  • nucleus
  • mediator complex
  • telomere maintenance
  • transcription from RNA polymerase II promoter
  • RNA polymerase II transcription mediator activity
  • MED11
  • mediator complex
  • transcription from RNA polymerase II promoter
  • structural molecule activity
  • RNA polymerase II transcription mediator activity
  • MED4
  • nucleus
  • mediator complex
  • transcription from RNA polymerase II promoter
  • RNA polymerase II transcription mediator activity
  • MED6
  • mediator complex
  • transcription from RNA polymerase II promoter
  • RNA polymerase II transcription mediator activity
  • MED7
  • nucleus
  • mediator complex
  • transcription from RNA polymerase II promoter
  • RNA polymerase II transcription mediator activity
  • MED8
  • mediator complex
  • transcription from RNA polymerase II promoter
  • RNA polymerase II transcription mediator activity
  • NUT1
  • nucleus
  • mitochondrion
  • regulation of transcription from RNA polymerase II promoter
  • molecular_function
  • NUT2
  • nucleus
  • mediator complex
  • transcription from RNA polymerase II promoter
  • RNA polymerase II transcription mediator activity
  • PGD1
  • nucleus
  • mediator complex
  • response to drug
  • telomere maintenance
  • transcription from RNA polymerase II promoter
  • RNA polymerase II transcription mediator activity
  • RGR1
  • nucleus
  • mediator complex
  • transcription from RNA polymerase II promoter
  • RNA polymerase II transcription mediator activity
  • SIN4
  • nucleus
  • mediator complex
  • transcription from RNA polymerase II promoter
  • RNA polymerase II transcription mediator activity
  • SRB2
  • mediator complex
  • telomere maintenance
  • transcription from RNA polymerase II promoter
  • RNA polymerase II transcription mediator activity
  • SRB4
  • mediator complex
  • transcription from RNA polymerase II promoter
  • RNA polymerase II transcription mediator activity
  • SRB5
  • mediator complex
  • telomere maintenance
  • transcription from RNA polymerase II promoter
  • RNA polymerase II transcription mediator activity
  • SRB6
  • mediator complex
  • transcription from RNA polymerase II promoter
  • structural molecule activity
  • RNA polymerase II transcription mediator activity
  • SRB7
  • nucleus
  • mediator complex
  • transcription from RNA polymerase II promoter
  • RNA polymerase II transcription mediator activity
  • SRB8
  • transcription factor complex
  • negative regulation of transcription from RNA polymerase II promoter
  • telomere maintenance
  • RNA polymerase II transcription mediator activity
  • SSN2
  • transcription factor complex
  • negative regulation of transcription from RNA polymerase II promoter
  • telomere maintenance
  • general RNA polymerase II transcription factor activity
  • SSN3
  • transcription factor complex
  • negative regulation of transcription from RNA polymerase II promoter
  • telomere maintenance
  • protein amino acid phosphorylation
  • regulation of transcription
  • meiosis
  • general RNA polymerase II transcription factor activity
  • cyclin-dependent protein kinase activity
  • Cellular Component Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    mediator complex 1.0307E-45 21 18 17 6292
    nucleoplasm part 6.0491E-28 21 245 20 6292
    nucleoplasm 2.8491E-27 21 264 20 6292
    nuclear lumen 1.85E-22 21 453 20 6292
    organelle lumen 3.8E-19 21 660 20 6292
    intracellular organelle lumen 3.8E-19 21 660 20 6292
    membrane-enclosed lumen 1.2451E-18 21 700 20 6292
    nuclear part 1.1424E-14 21 1103 20 6292
    protein complex 2.0945E-14 21 1137 20 6292
    macromolecular complex 2.8646E-11 21 1635 20 6292
    nucleus 5.0329E-11 21 2041 21 6292
    organelle part 2.0271E-8 21 2282 20 6292
    intracellular organelle part 2.0271E-8 21 2282 20 6292
    membrane-bounded organelle 2.0956E-5 21 3771 21 6292
    intracellular membrane-bounded organelle 2.0956E-5 21 3771 21 6292
    intracellular organelle 1.0447E-4 21 4070 21 6292
    organelle 1.0501E-4 21 4071 21 6292
    transcription factor complex 1.583E-3 21 71 3 6292
    intracellular part 6.1098E-3 21 4938 21 6292
    intracellular 7.149E-3 21 4975 21 6292

    Biological Process Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    transcription from RNA polymerase II promoter 9.7256E-28 21 335 21 6292
    transcription, DNA-dependent 6.1524E-24 21 503 21 6292
    RNA biosynthetic process 7.6048E-24 21 508 21 6292
    transcription 4.5016E-23 21 552 21 6292
    RNA metabolic process 5.1781E-18 21 954 21 6292
    cellular macromolecule biosynthetic process 5.3227E-16 21 1187 21 6292
    macromolecule biosynthetic process 5.5159E-16 21 1189 21 6292
    gene expression 2.7621E-15 21 1283 21 6292
    nucleic acid metabolic process 2.1931E-14 21 1415 21 6292
    nucleobase, nucleoside, nucleotide and nucleic acid metabolic process 1.871E-13 21 1566 21 6292
    cellular biosynthetic process 1.8964E-13 21 1567 21 6292
    biosynthetic process 3.0247E-13 21 1602 21 6292
    cellular nitrogen compound metabolic process 2.4869E-12 21 1770 21 6292
    nitrogen compound metabolic process 3.1903E-12 21 1791 21 6292
    cellular macromolecule metabolic process 5.4516E-10 21 2285 21 6292
    macromolecule metabolic process 9.7623E-10 21 2349 21 6292
    primary metabolic process 8.0566E-8 21 2896 21 6292
    cellular metabolic process 2.1337E-7 21 3033 21 6292
    metabolic process 4.9632E-7 21 3157 21 6292
    anatomical structure homeostasis 2.0055E-6 21 286 8 6292
    telomere organization 2.0055E-6 21 286 8 6292
    telomere maintenance 2.0055E-6 21 286 8 6292
    homeostatic process 2.8049E-5 21 408 8 6292
    chromosome organization 3.3835E-5 21 555 9 6292
    regulation of biological quality 2.3916E-4 21 551 8 6292
    DNA metabolic process 3.622E-4 21 585 8 6292
    cellular process 6.1031E-4 21 4426 21 6292
    negative regulation of transcription from RNA polymerase II promoter 9.7041E-4 21 60 3 6292
    regulation of transcription from RNA polymerase II promoter 6.1812E-3 21 228 4 6292
    organelle organization 6.8594E-3 21 1127 9 6292

    Molecular Function Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    RNA polymerase II transcription mediator activity 2.6668E-46 21 22 18 6292
    general RNA polymerase II transcription factor activity 1.0851E-40 21 64 20 6292
    RNA polymerase II transcription factor activity 9.1629E-34 21 130 20 6292
    transcription regulator activity 4.9407E-25 21 339 20 6292

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle