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View Protein Complex Details

Complex Overview

From Publication: Riffle <i>et al</i>. (2010) (Unpublished Data)
Notes: Complex predicted from the combined set of Gavin (2002), Gavin (2006), Ho (2002) and Krogan (2006); at p-value cutoff of 1E-7
Complex Size: 14 proteins

Complex Member Proteins

Protein

 GO Cellular Component GO Biological Process GO Molecular Function
BRR2
  • U4/U6 x U5 tri-snRNP complex
  • U5 snRNP
    		•
  • RNA splicing
  • mRNA metabolic process
  • auxin biosynthetic process
  • mRNA processing
  • spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)
    		•
  • ATP-dependent RNA helicase activity
    		•
    LSM2
  • U4/U6 x U5 tri-snRNP complex
  • nucleolus
  • U6 snRNP
  • small nucleolar ribonucleoprotein complex
    		•
  • mRNA catabolic process
  • nuclear mRNA splicing, via spliceosome
    		•
  • RNA binding
    		•
    LSM6
  • U4/U6 x U5 tri-snRNP complex
  • nucleolus
  • U6 snRNP
  • small nucleolar ribonucleoprotein complex
    		•
  • mRNA catabolic process
  • nuclear mRNA splicing, via spliceosome
    		•
  • RNA binding
    		•
    LSM7
  • U4/U6 x U5 tri-snRNP complex
  • nucleolus
  • U6 snRNP
  • small nucleolar ribonucleoprotein complex
    		•
  • telomere maintenance
  • mRNA catabolic process
  • nuclear mRNA splicing, via spliceosome
    		•
  • RNA binding
    		•
    PRP3
  • U4/U6 x U5 tri-snRNP complex
    		•
  • nuclear mRNA splicing, via spliceosome
    		•
  • molecular_function
    		•
    PRP31
  • mitochondrion
  • U4/U6 x U5 tri-snRNP complex
    		•
  • nuclear mRNA splicing, via spliceosome
    		•
  • RNA binding
  • molecular_function
    		•
    PRP4
  • U4/U6 x U5 tri-snRNP complex
    		•
  • nuclear mRNA splicing, via spliceosome
    		•
  • molecular_function
    		•
    PRP8
  • U4/U6 x U5 tri-snRNP complex
  • U5 snRNP
    		•
  • nuclear mRNA 3'-splice site recognition
  • nuclear mRNA splicing, via spliceosome
    		•
  • U5 snRNA binding
    		•
    SMB1
  • U4/U6 x U5 tri-snRNP complex
  • U5 snRNP
  • U1 snRNP
    		•
  • nuclear mRNA splicing, via spliceosome
    		•
  • RNA binding
  • molecular_function
    		•
    SMD1
  • commitment complex
  • U4/U6 x U5 tri-snRNP complex
  • U5 snRNP
  • U1 snRNP
    		•
  • nuclear mRNA splicing, via spliceosome
    		•
  • mRNA binding
    		•
    SMD2
  • U4/U6 x U5 tri-snRNP complex
  • U5 snRNP
  • U1 snRNP
    		•
  • nuclear mRNA splicing, via spliceosome
    		•
  • RNA binding
  • molecular_function
    		•
    SMD3
  • commitment complex
  • U4/U6 x U5 tri-snRNP complex
  • U5 snRNP
  • U1 snRNP
    		•
  • nuclear mRNA splicing, via spliceosome
    		•
  • mRNA binding
    		•
    SNU114
  • U4/U6 x U5 tri-snRNP complex
  • U5 snRNP
    		•
  • generation of catalytic spliceosome for first transesterification step
  • nuclear mRNA splicing, via spliceosome
    		•
  • GTP binding
  • U5 snRNA binding
  • GTPase activity
    		•
    SNU66
  • U4/U6 x U5 tri-snRNP complex
    		•
  • nuclear mRNA splicing, via spliceosome
    		•
  • RNA binding
  • molecular_function
    		•

    Cellular Component Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    		 P-value

    		 A

    		 B

    		 I

    		 T
    U4/U6 x U5 tri-snRNP complex 2.7357E-34 14 32 14 6292
    small nuclear ribonucleoprotein complex 2.1696E-29 14 63 14 6292
    U5 snRNP 1.5153E-16 14 14 7 6292
    ribonucleoprotein complex 5.0021E-16 14 514 14 6292
    nuclear part 2.4173E-11 14 1103 14 6292
    macromolecular complex 6.1412E-9 14 1635 14 6292
    U1 snRNP 3.5916E-8 14 17 4 6292
    nucleus 1.3856E-7 14 2041 14 6292
    organelle part 6.6422E-7 14 2282 14 6292
    intracellular organelle part 6.6422E-7 14 2282 14 6292
    U6 snRNP 1.4322E-6 14 11 3 6292
    commitment complex 2.9963E-4 14 12 2 6292
    U2-type spliceosomal complex 2.9963E-4 14 12 2 6292
    small nucleolar ribonucleoprotein complex 4.778E-4 14 72 3 6292
    membrane-bounded organelle 7.6409E-4 14 3771 14 6292
    intracellular membrane-bounded organelle 7.6409E-4 14 3771 14 6292
    intracellular organelle 2.2276E-3 14 4070 14 6292
    organelle 2.2353E-3 14 4071 14 6292
    spliceosomal complex 4.3098E-3 14 45 2 6292

    Biological Process Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    		 P-value

    		 A

    		 B

    		 I

    		 T
    nuclear mRNA splicing, via spliceosome 2.2052E-26 14 99 14 6292
    RNA splicing, via transesterification reactions with bulged adenosine as nucleophile 2.5642E-26 14 100 14 6292
    RNA splicing, via transesterification reactions 7.0578E-26 14 107 14 6292
    RNA splicing 1.589E-24 14 132 14 6292
    mRNA processing 1.8451E-23 14 156 14 6292
    mRNA metabolic process 1.702E-21 14 213 14 6292
    RNA processing 6.8385E-18 14 380 14 6292
    RNA metabolic process 3.1282E-12 14 954 14 6292
    gene expression 2.03E-10 14 1283 14 6292
    nucleic acid metabolic process 8.0503E-10 14 1415 14 6292
    nucleobase, nucleoside, nucleotide and nucleic acid metabolic process 3.3498E-9 14 1566 14 6292
    cellular nitrogen compound metabolic process 1.8728E-8 14 1770 14 6292
    nitrogen compound metabolic process 2.2103E-8 14 1791 14 6292
    cellular macromolecule metabolic process 6.7658E-7 14 2285 14 6292
    macromolecule metabolic process 9.9712E-7 14 2349 14 6292
    primary metabolic process 1.8826E-5 14 2896 14 6292
    cellular metabolic process 3.6009E-5 14 3033 14 6292
    metabolic process 6.3176E-5 14 3157 14 6292
    spliceosomal conformational changes to generate catalytic conformation 1.6406E-4 14 9 2 6292
    mRNA catabolic process 4.2141E-4 14 69 3 6292
    RNA catabolic process 6.5132E-4 14 80 3 6292
    ribonucleoprotein complex assembly 9.7992E-4 14 92 3 6292
    regulation of hormone levels 2.225E-3 14 1 1 6292
    spliceosome conformational change to release U4 (or U4atac) and U1 (or U11) 2.225E-3 14 1 1 6292
    auxin biosynthetic process 2.225E-3 14 1 1 6292
    auxin metabolic process 2.225E-3 14 1 1 6292
    hormone metabolic process 2.225E-3 14 1 1 6292
    hormone biosynthetic process 2.225E-3 14 1 1 6292
    nuclear mRNA 3'-splice site recognition 4.4455E-3 14 2 1 6292
    generation of catalytic spliceosome for first transesterification step 6.6614E-3 14 3 1 6292
    cellular macromolecular complex assembly 6.8483E-3 14 182 3 6292
    cellular process 7.2188E-3 14 4426 14 6292

    Molecular Function Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    		 P-value

    		 A

    		 B

    		 I

    		 T
    RNA binding 7.1505E-12 14 367 11 6292
    nucleic acid binding 4.6726E-9 14 666 11 6292
    U5 snRNA binding 4.5979E-6 14 2 2 6292
    binding 5.264E-6 14 1294 11 6292
    snRNA binding 4.5804E-5 14 5 2 6292
    mRNA binding 2.6233E-3 14 35 2 6292
    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle