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Protein Overview: KIN2

General Information:
Name(s) found: KIN2 / YLR096W [SGD]
Description(s) found:
Found 24 descriptions.
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  • Serine/threonine protein kinase involved in regulation of exocytosis; localizes to the cytoplasmic face of the plasma membrane; closely related to Kin1p [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 1147 amino acids

    Gene Ontology:
    Cellular Component: membrane fraction [IDALink to PubMed article]
    plasma membrane [IPILink to PubMed article]
    Biological Process: exocytosis [IGILink to PubMed article][IPILink to PubMed article]
    Molecular Function: protein kinase activity [IDALink to PubMed article][ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPNPNTADYL VNPNFRTSKG GSLSPTPEAF NDTRVAAPAT LRMMGKQSGP RNDQQQAPLM  60
   61 PPADIKQGKE QAAQRQNDAS RPNGAVELRQ FHRRSLGDWE FLETVGAGSM GKVKLVKHRQ 120
  121 TKEICVIKIV NRASKAYLHK QHSLPSPKNE SEILERQKRL EKEIARDKRT VREASLGQIL 180
  181 YHPHICRLFE MCTMSNHFYM LFEYVSGGQL LDYIIQHGSL KEHHARKFAR GIASALQYLH 240
  241 ANNIVHRDLK IENIMISSSG EIKIIDFGLS NIFDYRKQLH TFCGSLYFAA PELLKAQPYT 300
  301 GPEVDIWSFG IVLYVLVCGK VPFDDENSSI LHEKIKKGKV DYPSHLSIEV ISLLTRMIVV 360
  361 DPLRRATLKN VVEHPWMNRG YDFKAPSYVP NRVPLTPEMI DSQVLKEMYR LEFIDDIEDT 420
  421 RRSLIRLVTE KEYIQLSQEY WDKLSNAKGL SSSLNNNYLN STAQQTLIQN HITSNPSQSG 480
  481 YNEPDSNFED PTLAYHPLLS IYHLVSEMVA RKLAKLQRRQ ALALQAQAQQ RQQQQQVALG 540
  541 TKVALNNNSP DIMTKMRSPQ KEVVPNPGIF QVPAIGTSGT SNNTNTSNKP PLHVMVPPKL 600
  601 TIPEQAHTSP TSRKSSDIHT ELNGVLKSTP VPVSGEYQQR SASPVVGEHQ EKNTIGGIFR 660
  661 RISQSGQSQH PTRQQEPLPE REPPTYMSKS NEISIKVPKS HSRTISDYIP SARRYPSYVP 720
  721 NSVDVKQKPA KNTTIAPPIR SVSQKQNSDL PALPQNAELI VQKQRQKLLQ ENLDKLQIND 780
  781 NDNNNVNAVV DGINNDNSDH YLSVPKGRKL HPSARAKSVG HARRESLKFT RPPIPAALPP 840
  841 SDMTNDNGFL GEANKERYNP VSSNFSTVPE DSTTYSNDTN NRLTSVYSQE LTEKQILEEA 900
  901 SKAPPGSMPS IDYPKSMFLK GFFSVQTTSS KPLPIVRHNI ISVLTRMNID FKEVKGGFIC 960
  961 VQQRPSIETA AVPVITTTGV GLDSGKAMDL QNSLDSQLSS SYHSTASSAS RNSSIKRQGS1020
 1021 YKRGQNNIPL TPLATNTHQR NSSIPMSPNY GNQSNGTSGE LSSMSLDYVQ QQDDILTTSR1080
 1081 AQNINNVNGQ TEQTNTSGIK ERPPIKFEIH IVKVRIVGLA GVHFKKVSGN TWLYKELASY1140
 1141 ILKELNL

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) AIM3 BAR1 COA4 GYL1 GYP5 HNT1 KIN2 MEF2 NCP1 PCL10 PRP28 RVS161 RVS167 SAE2 SLK19 TIM21 VPS15
    View Details Ho Y, et al. (2002) AHA1 ARP2 BCK1 BUD14 CMP2 CPR6 DOG1 EGD2 FOL2 GAL7 GIS4 GND1 HSP104 IDH1 ILV5 IPP1 KEL1 KEL2 KIC1 KIN2 KRE6 LHS1 LYS12 MKK2 MKT1 OYE2 PDC6 PIL1 PMA1 POP2 QCR2 RCN2 RPN6 RPT3 SIS1 SKG3 SLT2 SMK1 TEF4 TFC4 TIF1, TIF2 UBA1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run BIR1 sample bir 1 from feb 2005 Sandall S, et all (2006)
    View Run ZDS1 Sample 3 - cpn + atp, from june 2005 McCusker D, et al (2007)
    View Run MLP2 #31 Asynchronous Prep (Protease cleavage) Keck JM, et al. (2011)
    View Run MLP2 #03 Alpha Factor Prep1-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #12 Mitotic Prep1-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #11 Mitotic Prep1-TiO2 enriched, new search criteria Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data KIN2 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..66] deduced N/A No confident structure predictions are available.
    2 View Details [67..207]
    [402..427]    		 PSI-BLAST 458.08661 Calmodulin-dependent protein kinase
    3 View Details [208..401] PSI-BLAST 458.08661 Calmodulin-dependent protein kinase
    4 View Details [428..505] PSI-BLAST 19.522879 Calmodulin
    5 View Details [506..569] PSI-BLAST 19.522879 Calmodulin
    6 View Details [570..930] ORFEUS 9.14 RBP1
    7 View Details [931..983] ORFEUS 8.1 Sec24
    8 View Details [984..1147] deduced N/A No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3 No functions predicted.
    4 No functions predicted.
    5 No functions predicted.
    6 No functions predicted.
    7 No functions predicted.
    8
    Term Confidence Notes
  • cAMP-dependent protein kinase activity
    		•  5.54746148555697 bayes_pls_golite062009
  • cyclic nucleotide-dependent protein kinase activity
    		•  5.45676068703911 bayes_pls_golite062009
  • protein kinase activity
    		•  4.05475891009228 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  4.04751809021925 bayes_pls_golite062009
  • kinase activity
    		•  3.88704262604357 bayes_pls_golite062009
  • protein serine/threonine kinase activity
    		•  3.7974128326421 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  3.55786569314106 bayes_pls_golite062009
  • transferase activity
    		•  2.750643926194 bayes_pls_golite062009
  • binding
    		•  2.41732321506551 bayes_pls_golite062009
  • ATP binding
    		•  1.44435058039859 bayes_pls_golite062009
  • adenyl ribonucleotide binding
    		•  1.41005152726625 bayes_pls_golite062009
  • adenyl nucleotide binding
    		•  1.38971642420542 bayes_pls_golite062009
  • eukaryotic elongation factor-2 kinase activator activity
    		•  1.2571693790189 bayes_pls_golite062009
  • eukaryotic elongation factor-2 kinase regulator activity
    		•  1.2571693790189 bayes_pls_golite062009
  • ribonucleotide binding
    		•  1.16863558166547 bayes_pls_golite062009
  • purine ribonucleotide binding
    		•  1.16859376715941 bayes_pls_golite062009
  • purine nucleotide binding
    		•  1.15633908642115 bayes_pls_golite062009
  • nucleotide binding
    		•  1.14964488472581 bayes_pls_golite062009
  • AMP-activated protein kinase activity
    		•  1.12923456567012 bayes_pls_golite062009
  • catalytic activity
    		•  0.836142537655721 bayes_pls_golite062009
  • protein binding
    		•  0.704339182896017 bayes_pls_golite062009
  • magnesium ion binding
    		•  0.439688030503848 bayes_pls_golite062009


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle