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View Structure Prediction Details

Protein: KIN2
Organism: Saccharomyces cerevisiae
Length: 1147 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for KIN2.

Description E-value Query
Range
Subject
Range
gi|171789 - gi|171789|gb|AAA34723.1| protein kinase 2
0.0 [1..1147] [1..1153]
gi|13561063 - gi|13561063|emb|CAA65500.1| protein kinase [Medicago sativa]
0.0 [19..571] [9..535]
gi|16215467 - gi|16215467|emb|CAC82998.1| calcium-dependent protein kinase 2 [Nicotiana tabacum]
0.0 [2..571] [8..557]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
0.0 [34..571] [23..531]
gi|15289760 - gi|15289760|dbj|BAB63464.1| calcium dependent protein kinase [Solanum tuberosum]
0.0 [74..585] [3..482]
CDPK6_ARATH - Calcium-dependent protein kinase 6 OS=Arabidopsis thaliana GN=CPK6 PE=1 SV=1
0.0 [27..588] [17..543]

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Predicted Domain #1
Region A:
Residues: [1-66]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPNPNTADYL VNPNFRTSKG GSLSPTPEAF NDTRVAAPAT LRMMGKQSGP RNDQQQAPLM  60
   61 PPADIK

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [67-207]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QGKEQAAQRQ NDASRPNGAV ELRQFHRRSL GDWEFLETVG AGSMGKVKLV KHRQTKEICV  60
   61 IKIVNRASKA YLHKQHSLPS PKNESEILER QKRLEKEIAR DKRTVREASL GQILYHPHIC 120
  121 RLFEMCTMSN HFYMLFEYVS G

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [402-427]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SQVLKEMYRL EFIDDIEDTR RSLIRL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 458.08661
Match: 1a06__
Description: Calmodulin-dependent protein kinase
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [208-401]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GQLLDYIIQH GSLKEHHARK FARGIASALQ YLHANNIVHR DLKIENIMIS SSGEIKIIDF  60
   61 GLSNIFDYRK QLHTFCGSLY FAAPELLKAQ PYTGPEVDIW SFGIVLYVLV CGKVPFDDEN 120
  121 SSILHEKIKK GKVDYPSHLS IEVISLLTRM IVVDPLRRAT LKNVVEHPWM NRGYDFKAPS 180
  181 YVPNRVPLTP EMID

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 458.08661
Match: 1a06__
Description: Calmodulin-dependent protein kinase
Matching Structure (courtesy of the PDB):

Predicted Domain #4
Region A:
Residues: [428-505]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VTEKEYIQLS QEYWDKLSNA KGLSSSLNNN YLNSTAQQTL IQNHITSNPS QSGYNEPDSN  60
   61 FEDPTLAYHP LLSIYHLV

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 19.522879
Match: 1ahr__
Description: Calmodulin
Matching Structure (courtesy of the PDB):

Predicted Domain #5
Region A:
Residues: [506-569]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SEMVARKLAK LQRRQALALQ AQAQQRQQQQ QVALGTKVAL NNNSPDIMTK MRSPQKEVVP  60
   61 NPGI

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 19.522879
Match: 1ahr__
Description: Calmodulin
Matching Structure (courtesy of the PDB):

Predicted Domain #6
Region A:
Residues: [570-930]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 FQVPAIGTSG TSNNTNTSNK PPLHVMVPPK LTIPEQAHTS PTSRKSSDIH TELNGVLKST  60
   61 PVPVSGEYQQ RSASPVVGEH QEKNTIGGIF RRISQSGQSQ HPTRQQEPLP EREPPTYMSK 120
  121 SNEISIKVPK SHSRTISDYI PSARRYPSYV PNSVDVKQKP AKNTTIAPPI RSVSQKQNSD 180
  181 LPALPQNAEL IVQKQRQKLL QENLDKLQIN DNDNNNVNAV VDGINNDNSD HYLSVPKGRK 240
  241 LHPSARAKSV GHARRESLKF TRPPIPAALP PSDMTNDNGF LGEANKERYN PVSSNFSTVP 300
  301 EDSTTYSNDT NNRLTSVYSQ ELTEKQILEE ASKAPPGSMP SIDYPKSMFL KGFFSVQTTS 360
  361 S

[Run NCBI BLAST on this sequence.]

Detection Method: ORFEUS
Confidence: 9.14
Match: 1k83A
Description: RBP1
Matching Structure (courtesy of the PDB):

Predicted Domain #7
Region A:
Residues: [931-983]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KPLPIVRHNI ISVLTRMNID FKEVKGGFIC VQQRPSIETA AVPVITTTGV GLD

[Run NCBI BLAST on this sequence.]

Detection Method: ORFEUS
Confidence: 8.1
Match: 1m2vB
Description: Sec24
Matching Structure (courtesy of the PDB):

Predicted Domain #8
Region A:
Residues: [984-1147]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SGKAMDLQNS LDSQLSSSYH STASSASRNS SIKRQGSYKR GQNNIPLTPL ATNTHQRNSS  60
   61 IPMSPNYGNQ SNGTSGELSS MSLDYVQQQD DILTTSRAQN INNVNGQTEQ TNTSGIKERP 120
  121 PIKFEIHIVK VRIVGLAGVH FKKVSGNTWL YKELASYILK ELNL

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted functions:

Term Confidence Notes
cAMP-dependent protein kinase activity 5.54746148555697 bayes_pls_golite062009
cyclic nucleotide-dependent protein kinase activity 5.45676068703911 bayes_pls_golite062009
protein kinase activity 4.05475891009228 bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor 4.04751809021925 bayes_pls_golite062009
kinase activity 3.88704262604357 bayes_pls_golite062009
protein serine/threonine kinase activity 3.7974128326421 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 3.55786569314106 bayes_pls_golite062009
transferase activity 2.750643926194 bayes_pls_golite062009
binding 2.41732321506551 bayes_pls_golite062009
ATP binding 1.44435058039859 bayes_pls_golite062009
adenyl ribonucleotide binding 1.41005152726625 bayes_pls_golite062009
adenyl nucleotide binding 1.38971642420542 bayes_pls_golite062009
eukaryotic elongation factor-2 kinase activator activity 1.2571693790189 bayes_pls_golite062009
eukaryotic elongation factor-2 kinase regulator activity 1.2571693790189 bayes_pls_golite062009
ribonucleotide binding 1.16863558166547 bayes_pls_golite062009
purine ribonucleotide binding 1.16859376715941 bayes_pls_golite062009
purine nucleotide binding 1.15633908642115 bayes_pls_golite062009
nucleotide binding 1.14964488472581 bayes_pls_golite062009
AMP-activated protein kinase activity 1.12923456567012 bayes_pls_golite062009
catalytic activity 0.836142537655721 bayes_pls_golite062009
protein binding 0.704339182896017 bayes_pls_golite062009
magnesium ion binding 0.439688030503848 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle